cyclopropyl(4-(3-(1-piperazinyl)propoxy)phenyl)methanone | 360553-47-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cyclopropyl(4-(3-(1-piperazinyl)propoxy)phenyl)methanone
• 英文别名: cyclopropyl-[4-(3-piperazin-1-ylpropoxy)phenyl]methanone
• CAS: 360553-47-5
• 化学式: C₁₇H₂₄N₂O₂
• 分子量: 288.39
• InChiKey: YWPKIICGNYSKQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  454.7±35.0 °C(Predicted)
• 密度：
  1.122±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cyclopropyl(4-(3-(1-piperazinyl)propoxy)phenyl)methanone 在 4-二甲氨基吡啶 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 2-amino-1-[4-[3-[4-(cyclopropanecarbonyl)phenoxy]propyl]piperazin-1-yl]-3-naphthalen-1-ylpropan-1-one
  参考文献：
  名称：

  Structure–Activity relationships of non-imidazole H3 Receptor ligands. Part 2: binding preference for d-Amino acids motifs

  摘要：

  Structure-activity relationship studies on novel non-imidazole, D-amino acid containing ligands of histamine 3 receptors are presented. A-304121 is a D-alanine piperazine amide with high affinity at the rat H-3 receptor. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00310-4
• 作为产物：
  描述：

  4-氯-4′-羟基苯丁酮 在 sodium hydroxide 、 potassium carbonate 、 potassium iodide 作用下， 以 丁酮 为溶剂， 反应 24.0h， 生成 cyclopropyl(4-(3-(1-piperazinyl)propoxy)phenyl)methanone
  参考文献：
  名称：

  Structure–Activity relationships of non-imidazole H3 Receptor ligands. Part 2: binding preference for d-Amino acids motifs

  摘要：

  Structure-activity relationship studies on novel non-imidazole, D-amino acid containing ligands of histamine 3 receptors are presented. A-304121 is a D-alanine piperazine amide with high affinity at the rat H-3 receptor. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00310-4

文献信息

• Cyclic and bicyclic diamino histamine-3 receptor antagonists
  申请人：——

  公开号：US20010049367A1

  公开（公告）日：2001-12-06

  Compounds of formula (I) 1 compounds of formula (II) 2 compounds of formula (III) 3 and compounds of formula (IV) 4 or pharmaceutically acceptable salts thereof are useful as H 3 receptor antagonists. Processes to make the compounds and methods of treatment using the compounds are also disclosed.

  化合物的公式(I)1、公式(II)2、公式(III)3和公式(IV)4或其药学上可接受的盐被用作H3受体拮抗剂。还公开了制备这些化合物的方法以及使用这些化合物的治疗方法。
• US6559140B2
  申请人：——

  公开号：US6559140B2

  公开（公告）日：2003-05-06
• [EN] CYCLIC AND BICYCLIC DIAMINO HISTAMINE-3 RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR D'HISTAMINE-3 DIAMINO CYCLIQUES ET BICYCLIQUES
  申请人：ABBOTT LAB

  公开号：WO2001066534A2

  公开（公告）日：2001-09-13

  Compounds of formula (I), compounds of formula (II), compounds of formula (III), and compounds of formula (IV), or pharmaceutically acceptable salts thereof are useful as H3 receptor antagonists. Processes to make the compounds and methods of treatment using the compounds are also disclosed.
• Structure–Activity relationships of non-imidazole H3 Receptor ligands. Part 2: binding preference for d-Amino acids motifs
  作者：Ramin Faghih、Wesley Dwight、Larry Black、Huaqing Liu、Robert Gentles、Kathleen Phelan、Timothy A Esbenshade、Lynne Ireland、Thomas R Miller、Chae-Hee Kang、Kathy M Krueger、Gerard B Fox、Arthur A Hancock、Youssef L Bennani

  DOI：10.1016/s0960-894x(02)00310-4

  日期：2002.8

  Structure-activity relationship studies on novel non-imidazole, D-amino acid containing ligands of histamine 3 receptors are presented. A-304121 is a D-alanine piperazine amide with high affinity at the rat H-3 receptor. (C) 2002 Elsevier Science Ltd. All rights reserved.