Diethyl 4-Methylcyclohexane-1,1-dicarboxylate | 53695-40-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Diethyl 4-Methylcyclohexane-1,1-dicarboxylate
• 英文别名: 4-methyl-cyclohexane-1,1-dicarboxylic acid diethyl ester；4-Methyl-cyclohexan-1,1-dicarbonsaeure-diaethylester；4-Methylcyclohexan-1,1-dicarbonsaeureethylester；Diethyl-4-methyl-cyclohexan-1,1-dicarboxylat；Ethyl-4-methyl-cyclohexan-1,1-dicarboxylate；Ethyl-4-methylcyclohexan-1,1-dicarboxylate
• CAS: 53695-40-2
• 化学式: C₁₃H₂₂O₄
• mdl: MFCD21463421
• 分子量: 242.315
• InChiKey: FNKORLJHALWWCQ-UHFFFAOYSA-N

物化性质

• 沸点：
  125-127 °C(Press: 8 Torr)
• 密度：
  1.0154 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.846
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Diethyl 4-Methylcyclohexane-1,1-dicarboxylate 在 sodium ethanolate 、 尿素 作用下， 生成 9-methyl-2,4-diaza-spiro[5.5]undecane-1,3,5-trione
  参考文献：
  名称：

  A history of instructional design and technology: Part I: A history of instructional media

  摘要：

  This is the first of a two-part article that will discuss the history of the field of instructional design and technology in the United States. A definition of the field is provided and the major features of the definition are identified. A rational for using instructional design and technology as the label for the field is also presented. Events in the history of instructional media,from the early 1900s to the present day, are described. The birth of school museums, the visual and audiovisual instruction movements, the use of media during World War II, and the interest in instructional television, computers, and the Internet are among the topics discussed. The article concludes with a summarization of the effects media have had on instructional practices, and a prediction regarding the effect computers, the Internet, and other digital media will have on such practices over the next decade.

  DOI：

  10.1007/bf02504506
• 作为产物：
  描述：

  对甲基苯甲酸 在 Rh/Al₂O₃ 正丁基锂 、 硫酸 、 氢气 、 二异丙胺 作用下， 以 乙醇 、 苯 为溶剂， 反应 20.0h， 生成 Diethyl 4-Methylcyclohexane-1,1-dicarboxylate
  参考文献：
  名称：

  Stereochemistry of decarbalkoxylation of cyclic geminal diesters effected by water and lithium chloride in dimethyl sulfoxide

  摘要：

  DOI：

  10.1021/jo01309a007

文献信息

• OLEFIN POLYMERIZATION CATALYST, PROCESS FOR PRODUCING OLEFIN POLYMER, POLYPROPYLENE RESIN COMPOSITION AND ARTICLE COMPRISING THE SAME
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20130109789A1

  公开（公告）日：2013-05-02

  An olefin polymerization catalyst is obtained by bringing the following components (A), (B) and (C) into contact with one another: (A) a solid catalyst component for olefin polymerization containing a titanium atom, a magnesium atom and a halogen atom; (B) an organoaluminum compound; and (C) a triether represented by formula (I). An olefin polymerization solid catalyst can be provided having a sufficiently high polymerization activity and an ability to produce an olefin polymer with a low content of low-molecular weight components and amorphous components.

  一种烯烃聚合催化剂是通过将以下组分（A）、（B）和（C）彼此接触而获得的：（A）用于烯烃聚合的固体催化剂组分，其中包含钛原子、镁原子和卤素原子；（B）有机铝化合物；以及（C）由式（I）表示的三醚。可以提供具有足够高的聚合活性和能够产生低分子量成分和非晶态成分含量低的烯烃聚合物的固体聚合催化剂。
• Synthesis and evaluation of DAG-lactone derivatives with HIV-1 latency reversing activity
  作者：Takahiro Ishii、Takuya Kobayakawa、Kouki Matsuda、Kohei Tsuji、Nami Ohashi、Shingo Nakahata、Airi Noborio、Kazuhisa Yoshimura、Hiroaki Mitsuya、Kenji Maeda、Hirokazu Tamamura

  DOI：10.1016/j.ejmech.2023.115449

  日期：2023.8

  Cells latently infected with human immunodeficiency virus type 1 (HIV-1) prevent people living with HIV-1 from obtaining a cure to the infectious disease. Latency reversing agents (LRAs) such as protein kinase C (PKC) activators and histone deacetylase (HDAC) inhibitors can reactivate cells latently infected with HIV-1. Several trials based on treatment with HDAC inhibitors alone, however, failed to

  潜伏感染 1 型人类免疫缺陷病毒 (HIV-1) 的细胞会阻止 HIV-1 感染者获得传染病的治愈方法。蛋白激酶 C (PKC) 激活剂和组蛋白脱乙酰酶 (HDAC) 抑制剂等潜伏期逆转剂 (LRA) 可以重新激活潜伏感染 HIV-1 的细胞。然而，几项仅基于 HDAC 抑制剂治疗的试验未能减少潜在 HIV-1 病毒库的数量。在此，我们重点关注二酰基甘油 (DAG)-内酯衍生物 YSE028 ( 1 )，它是一种 PKC 激活剂，具有潜伏期逆转活性且无明显细胞毒性。 YSE028 ( 1 ) 的 Caspase-3 激活导致细胞凋亡，特别是在 HIV-1 潜伏感染细胞中。 YSE028 ( 1 ) 的构效关系研究已经产生了几种有用的衍生物。其中，化合物2在重新激活潜伏感染HIV-1的细胞方面比YSE028( 1 )强大约十倍。 DAG-内酯衍生物的活性与 PKC 的结合亲和力以及对酯酶介导的水解的稳定性相关。
• SOLID CATALYST COMPONENT AND CATALYST FOR POLYMERIZATION OF OLEFINS, AND PROCESS FOR PRODUCTION OF OLEFIN POLYMERS USING SAME
  申请人：Toho Titanium CO., LTD.

  公开号：EP2360190A1

  公开（公告）日：2011-08-24

  A solid catalyst component for olefin polymerization is produced by causing (a) a solid component that includes magnesium, titanium, a halogen, and an electron donor, (b) an aminosilane compound shown by the following general formula (1), and (c) at least one organosilicon compound selected from an organosilicon compound shown by the following general formula (2-A) and an organosilicon compound shown by the following general formula (2-B) to come in contact with each other. A polymer having high stereoregularity is produced in high yield while achieving a high melt flow rate due to hydrogen by polymerizing an olefin in the presence of a catalyst that includes the solid catalyst component.         R1nSi(NR2R3)4-n     (1)         [CH2=CH-(CH2)1]qSiR44-q     (2-A)         R5Si(OR6)4-s     (2-B)

  一种用于烯烃聚合的固体催化剂组分是通过使(a)一种包括镁、钛、卤素和电子供体的固体组分，(b)如下通式(1)所示的氨基硅烷化合物，和(c)至少一种选自如下通式(2-A)所示的有机硅化合物和如下通式(2-B)所示的有机硅化合物的有机硅化合物相互接触而制得的。在含有固体催化剂组分的催化剂存在下，通过聚合烯烃，可以高产率地生产出具有高立体规整度的聚合物，同时由于氢气的存在，可以达到较高的熔体流动速率。 R1nSi(NR2R3)4-n (1) [CH2=CH-(CH2)1]qSiR44-q (2-A) R5Si(OR6)4-s (2-B)
• METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, CATALYST FOR OLEFIN POLYMERIZATION, AND OLEFIN POLYMERS
  申请人：Toho Titanium Co., Ltd.

  公开号：EP2636688A1

  公开（公告）日：2013-09-11

  An environmentally-friendly solid catalyst component for olefin polymerization exhibits high hydrogen activity and high polymerization activity, can produce a polymer that exhibits a high MFR and high stereoregularity in high yield using a small amount of hydrogen, and exhibits high copolymerization activity and excellent copolymerization properties (e.g., block ratio). The solid catalyst component for olefin polymerization is produced by bringing (a) a magnesium compound, (b) an internal electron donor, and (c) a tetravalent-element halogen compound into contact with each other in an inert organic solvent, the internal electron donor (b) being represented by R12C(COOCH3)2 (wherein R1 is selected from a branched alkyl group having 3 to 20 carbon atoms, a halogen atom, a linear or branched halogen-substituted alkyl group having 2 to 20 carbon atoms, a linear alkyl group having 1 to 20 carbon atoms, a cycloalkyl group having 3 to 20 carbon atoms, a vinyl group, and an allyl group).

  一种用于烯烃聚合的环境友好型固体催化剂组分具有高氢活性和高聚合活 性，可使用少量氢气生产出高 MFR 和高立体规整度的聚合物，并具有高共聚活 性和优异的共聚特性（如嵌段比）。用于烯烃聚合的固体催化剂组分是通过在惰性有机溶剂中使(a)镁化合物、(b)内部电子供体和(c)四价元素卤素化合物相互接触而制得的、内部电子供体 (b) 由 R12C(COOCH3)2 表示（其中 R1 选自具有 3 至 20 个碳原子的支链烷基、卤原子、具有 2 至 20 个碳原子的直链或支链卤代烷基、具有 1 至 20 个碳原子的直链烷基、具有 3 至 20 个碳原子的环烷基、乙烯基和烯丙基）。
• KRAPCHO A. P.; WEIMASTER J. F., J. ORG. CHEM., 1980, 45, NO 21, 4105-4111
  作者：KRAPCHO A. P.、 WEIMASTER J. F.

  DOI：——

  日期：——