1-(4-hydroxy-3-dimethylamino-phenyl)ethanone | 56041-61-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-hydroxy-3-dimethylamino-phenyl)ethanone
• 英文别名: 1-[3-(dimethylamino)-4-hydroxyphenyl]ethanone；1-(4-hydroxy-3-dimethylaminophenyl)ethanone；3'-dimethylamino-4'-hydroxyacetophenone；4-Hydroxy-3-dimethylaminoacetophenon
• CAS: 56041-61-3
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: XIJFZWYCMCZYSQ-UHFFFAOYSA-N

物化性质

• 熔点：
  98-99 °C(Solv: hexane (110-54-3))
• 沸点：
  318.5±27.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  三氟甲磺酸酐 、 1-(4-hydroxy-3-dimethylamino-phenyl)ethanone 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 4-acetyl-2-(dimethylamino)phenyl trifluoromethanesulfonate
  参考文献：
  名称：

  [EN] AMIDE COMPOUNDS FOR THE TREATMENT OF HYPERLIPIDEMIA
  [FR] COMPOSES AMIDE

  摘要：

  公开号：

  WO2004039795A3
• 作为产物：
  描述：

  4'-羟基-3'-硝基苯乙酮 生成 1-(4-hydroxy-3-dimethylamino-phenyl)ethanone
  参考文献：
  名称：

  DAVE M. A.; KULKARNI A. B., INDIAN J. CHEM. , 1975, 13, NO 1, 33-34

  摘要：

  DOI：

文献信息

• 1-(arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-4-(heteroaryl)
  申请人：Hoechst Roussel Pharmaceuticals, Inc.

  公开号：US05605913A1

  公开（公告）日：1997-02-25

  Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. the compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

  杂芳基哌啶、吡咯烷和哌嗪作为抗精神病和镇痛剂是有用的。这些化合物特别适用于通过向哺乳动物施用治疗精神病有效量的其中一种化合物来治疗精神病。这些化合物的长效衍生物对于提供这些化合物的长期作用是有用的。通过向哺乳动物施用镇痛有效量的其中一种化合物，这些化合物也作为镇痛剂有用。
• Heteroarylpiperidines, pyrrolidines and piperazines and their use as
  申请人：Hoechst-Roussel Pharmaceuticals, Inc.

  公开号：US05364866A1

  公开（公告）日：1994-11-15

  Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

  吡啶基哌啶、吡咯烷和哌嗪等杂环哌啶类化合物可用作抗精神病和镇痛剂。这些化合物特别适用于通过向哺乳动物施用其中一种化合物的抗精神病有效量来治疗精神病。这些化合物也可通过向哺乳动物施用其中一种化合物的镇痛有效量来用作镇痛剂。
• [EN] HETEROARYLPIPERIDINES, PYRROLIDINES AND PIPERAZINES AND THEIR USE AS ANTIPSYCHOTICS AND ANALGETICS
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS, INC.

  公开号：WO1993009102A1

  公开（公告）日：1993-05-13

  (EN) Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.(FR) Des hétéroarylpiperidines, pyrrolidines et piperazines sont utiles comme agents neuroleptiques et analgésiques. Les composés sont particulièrement utiles dans le traitement de psychoses par administration à un mammifère d'une dose efficace de traitement de psychose d'un des composés. Les composés sont également utiles en tant qu'analgésiques par administration à un mammifère d'une dose efficace calmant la douleur d'un des composés.

  (中文) 杂环芳基哌啶、吡咯烷和哌嗪是作为抗精神病和镇痛剂的有用化合物。这些化合物特别适用于通过向哺乳动物施用其中一种化合物的精神病治疗有效剂量来治疗精神病。这些化合物也可以通过向哺乳动物施用其中一种化合物的止痛有效剂量来作为镇痛剂使用。
• Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics.
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP1052255A1

  公开（公告）日：2000-11-15

  Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

  杂环芳基哌啶、吡咯烷和哌嗪可用作抗精神病和镇痛剂。这些化合物尤其适用于通过向哺乳动物投与化合物的精神病治疗有效量来治疗精神病。这些化合物也可通过向哺乳动物投与化合物的镇痛有效量来用作镇痛剂。
• Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgetics
  申请人：Aventis Pharmaceuticals Inc.

  公开号：EP2311824A1

  公开（公告）日：2011-04-20

  Heteroarylpiperidines, pyrrolidines, and piperazines of the formula wherein X is -O-, -S-, -NH-, or -N(R2)- R2 is selected from the group consisting of lower alkyl, aryl lower alkyl, aryl, cycloalkyl, aroyl, alkanoyl, alkoxycarbonyl and phenylsulfonyl groups; p is 1 or 2 Y is hydrogen, lower alkyl, hydroxy, chlorine, fluorine, bromine, iodine, lower alkoxy, trifluoromethyl, nitro, or amino; Q1 is selected from the group consisting of: and where Z is are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a psychoses-treating effective amount of one of the compounds. Depot derivatives of the compounds are useful for providing long acting effects of the compounds. The compounds are also useful as analgesics by administering a pain-relieving effective amount of one of the compounds to a mammal.

  式中X为-O-，-S-，-NH-或-N（R2）-，R2选自下列组：低烷基，芳基低烷基，芳基，环烷基，芳香酰基，烷酰基，烷氧羰基和苯基磺酰基基团；p为1或2；Y为氢，低烷基，羟基，氯，氟，溴，碘，低烷氧基，三氟甲基，硝基或氨基；Q1选自下列组：其中Z为，本发明化合物作为抗精神病和镇痛剂具有应用价值。该化合物特别适用于通过向哺乳动物施用化合物的精神病治疗有效量来治疗精神病。该化合物的沉积物衍生物可用于提供化合物的长效作用。该化合物也可通过向哺乳动物施用缓解疼痛的有效量的化合物来用作镇痛剂。