甲氧基亚甲基环十二烷 | 73314-69-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 甲氧基亚甲基环十二烷
• 英文名称: methoxymethylenecyclododecane
• 英文别名: methoxymethylene cyclododecane；(Methoxymethylene)cyclododecane；methoxymethylidenecyclododecane
• CAS: 73314-69-9
• 化学式: C₁₄H₂₆O
• 分子量: 210.36
• InChiKey: ADXOLISMOZTUFE-UHFFFAOYSA-N

物化性质

• 沸点：
  297.8±9.0 °C(Predicted)
• 密度：
  0.889±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲氧基亚甲基环十二烷 在 双氧水 、 臭氧 作用下， 以 乙醚 为溶剂， 以33%的产率得到(cyclododecylidene)bishydroperoxide
  参考文献：
  名称：

  Synthesis, crystal structure and anti-malarial activity of novel spiro-1,2,4,5-tetraoxacycloalkanes

  摘要：

  （环亚烷基）双过氧化物 3 在 CsOH-H2O 存在下与 1,n-二卤代烷（n = 3-6）在 DMF 中反应，生成相应的 spiro-1,2,4,5-四氧杂环烷烃 4，产率中等。化合物 4ba 对恶性疟原虫（P. falciparum）表现出显著的抗疟活性（体外实验）。© 1999 Elsevier Science Ltd. 保留所有权利。

  DOI：

  10.1016/s0040-4039(99)00653-x

文献信息

• Novel compounds and antimalarials
  申请人：Wataya Yusuke

  公开号：US20050131058A1

  公开（公告）日：2005-06-16

  The present invention is to provide an antimalarial agent having excellent antimalarial activity with little side effects, in particular, having remarkable antimalarial activity against drug-resistant malaria parasites, and being capable of increasing solubility not only to organic solvent including olive oil, but also to water, and therefore, being usable not only as oral drugs but also as injectable solutions. The antimalarial agent of the present invention contains a compound represented by the following general formula (I) [wherein Z represents an unsubstituted or optionally substituted alicyclic hydrocarbon group, R 0 represents a water-soluble functional group, m represents anyone of integers of from 0 to 6, n represents any one of integers of from 0 to 10.].

  本发明旨在提供一种抗疟药剂，它具有极好的抗疟活性，副作用小，特别是对抗药性疟原虫具有显著的抗疟活性，不仅对有机溶剂（包括橄榄油）的溶解度增加，而且对水的溶解度也增加，因此不仅可用作口服药物，也可用作注射溶液。本发明的抗疟药物含有由以下通式（I）代表的化合物[其中 Z 代表未取代或任选取代的脂环烃基，R 0 代表水溶性官能团，m 代表 0 至 6 的任意整数，n 代表 0 至 10 的任意整数]。
• Synthesis and Antimalarial Activity of Novel Medium-Sized 1,2,4,5-Tetraoxacycloalkanes
  作者：Hye-Sook Kim、Yukiko Nagai、Kanako Ono、Khurshida Begum、Yusuke Wataya、Yoshiaki Hamada、Kaoru Tsuchiya、Araki Masuyama、Masatomo Nojima、Kevin J. McCullough

  DOI：10.1021/jm010026g

  日期：2001.7.1

  CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n.-dihaloalkanes (n = 3-8) provided the corresponding medium-sized 1,2,4,5-tetraoxacycloalkanes 4-8 in moderate yields. Subsequent evaluation of the antimalarial activity of the cyclic peroxides 4-8 in vitro and in vivo revealed that 1,2,6,7-tetraoxaspiro [7.11]nonadecane 4a has considerable potential as a new, inexpensive, and potent antimalarial drug.
• Synthesis and Notable Antimalarial Activity of Acyclic Peroxides, 1-(Alkyldioxy)-1-(methyldioxy)cyclododecanes
  作者：Yoshiaki Hamada、Hidekazu Tokuhara、Araki Masuyama、Masatomo Nojima、Hye-Sook Kim、Kanako Ono、Naoki Ogura、Yusuke Wataya

  DOI：10.1021/jm010473w

  日期：2002.3.1

  Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).
• Formation of 1,2-dioxetanes and probable trapping of an intermediate in the reactions of some enol ethers with singlet oxygen
  作者：E. W. H. Asveld、Richard M. Kellogg

  DOI：10.1021/ja00530a065

  日期：1980.5
• NOVEL COMPOUNDS AND ANTIMALARIALS
  申请人：Okayama University

  公开号：EP1496056B1

  公开（公告）日：2011-10-26