3-methoxy-9-cyanophenanthrene | 65514-29-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 3-methoxy-9-cyanophenanthrene
• 英文别名: 3-methoxyphenanthrene-9-carbonitrile；3-Methoxy-9-cyanophenanthren；3-Methoxyphenanthrene-9-carbonitrile
• CAS: 65514-29-6
• 化学式: C₁₆H₁₁NO
• 分子量: 233.269
• InChiKey: UCLVHLWIDBKBKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  33
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-methoxy-9-cyanophenanthrene 在 二碘甲烷 、 di-μ-hydroxo-bis[(N,N,N'N'-tetramethylethylenediamine)copper(II)] chloride 、 caesium carbonate 、 lithium bromide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 20.0~180.0 ℃ 、101.33 kPa 条件下， 反应 6.17h， 生成 diphenanthro[3,4-d:4′,3′-f][1,3]dioxepine-5,15-dicarbonitrile
  参考文献：
  名称：

  对映体纯5,13-二氰基-9-氧杂[7]螺烯的合成与研究

  摘要：

  光学纯的二氰基氧杂[7]螺旋烯和类螺旋烯分子已被制备并研究了它们的光学行为。中间体4,4'-联苯-蒽-3,3'-二醇的异构体通过物理分离其1-碳酸薄荷酯衍生物来拆分。在这项工作中，开发了一种在氰基存在下裂解 ArOMe 的温和方法。观察到阻转异构二醇、类螺旋烯化合物和氧杂[7]螺旋烯的旋光度呈递增顺序，同时这些分子也对圆偏振发光表现出良好的响应。

  DOI：

  10.1002/ejoc.201800922
• 作为产物：
  描述：

  3-菲醇 在 吡啶 、 盐酸 、 tin 、 磺酰氯 、 copper(II) sulfate 、 溶剂黄146 作用下， 生成 3-methoxy-9-cyanophenanthrene
  参考文献：
  名称：

  Prevalence and severity of substance misuse among referrals to a local forensic service

  摘要：

  Substance misuse is frequently present alongside mental illness and personality disorder, complicating all aspects of management. We describe self-reported levels of substance misuse in referrals to a forensic psychiatry service, to establish degrees of dependency and co-morbidity with other diagnostic categories and to report the implications for treatment. There were 146 (70%) of 209 consecutive referrals who completed a semi-structured questionnaire, including the Alcohol Use Disorders Identification Test (AUDIT), Severity of Alcohol Dependency Questionnaire (SADQ), Alcohol Problem Questionnaire (APQ) and, for frequent users of opiates or stimulants, the Severity of Dependence Scales (SDS). Psychiatric diagnoses were made from clinical assessment using the International Classification of Diseases (World Health Organization, 1992). ICD-10 diagnoses of substance misuse were found in 83 (57%) subjects. A combination of mental illness and a substance misuse diagnosis was found in 54 (37%). The subgroup accepted into forensic psychiatric services was found to have higher levels of co-morbidity, although levels of dependency were low. Forensic services need expertise in assessing drug-related morbidity; in motivational interviewing and other techniques for encouraging change; and in consolidating recovery.

  DOI：

  10.1080/09585180110057154

文献信息

• A Facile Synthesis of 2H-Chromenes and 9-Functionalized Phenanthrenes through Reactions between α,β-Unsaturated Compounds and Arynes
  作者：Tiexin Zhang、Xian Huang、and Luling Wu

  DOI：10.1002/ejoc.201200042

  日期：2012.6

  Facile syntheses of 2H-chromenes or 9-functionalized phenanthrenes under mild conditions in moderate to good yields have been developed. They each involve annulations of arynes with α,β-unsaturated compounds bearing different electron-withdrawing groups (EWGs). Depending on the natures of the different EWGs, the reactions proceed by different pathways: enals react with arynes through a tandem [2+2]

  已经开发了在温和条件下以中等至良好产率轻松合成 2H-色烯或 9-官能化菲的方法。它们都涉及芳炔与带有不同吸电子基团 (EWG) 的 α,β-不饱和化合物的环化。根据不同 EWG 的性质，反应通过不同途径进行：烯醛与芳炔通过串联 [2+2] 环加成/热电环开环/6e-电环化序列反应得到 2H-色烯，而酰基-/乙氧羰基/氰基取代的苯乙烯与芳烃发生狄尔斯-阿尔德反应，然后芳构化得到9-官能化的菲。已经研究并详细讨论了范围、局限性、区域选择性和机制。
• Synthesis and characterization of phenanthrene derivatives for optoelectronic applications
  作者：Sondes Raouafi、Faouzi Aloui、Amal Raouafi、Béchir Ben Hassine

  DOI：10.1016/j.crci.2017.03.004

  日期：2017.7

  Abstract New phenanthrene derivatives, bearing cyano group at selected positions, have been prepared in good yields through Knoevenagel condensation and classical oxidative photocyclization. The optical properties of the cyanophenanthrenes have been investigated by UV–vis absorption. A cyclic voltammetry analysis showed a relatively high electronic affinity, indicating that they may be good candidates

  摘要 通过 Knoevenagel 缩合和经典的氧化光环化反应以良好的收率制备了在选定位置带有氰基的新型菲衍生物。已经通过紫外-可见吸收研究了氰基菲的光学性质。循环伏安分析显示出相对较高的电子亲和力，表明它们可能是有机发光二极管中电子注入空穴阻挡层的良好候选者。
• Consumer Product Compositions
  申请人：The Procter & Gamble Company

  公开号：US20150210964A1

  公开（公告）日：2015-07-30

  Consumer product compositions comprise a water soluble organic photoactivator, an electron acceptor which accepts an electron from the photoactivator when the photoactivator is in a photo-excited state and/or reduced state, and a benefit active precursor which converts into a benefit active agent via electron transfer. The electron acceptor is preferably not covalently linked to the photoactivator. Also disclosed are methods of making a benefit active, comprising exposing the consumer product compositions to light, preferably having a wavelength greater than about 350 nm.

  消费品组成物包括水溶性有机光活化剂、电子受体和受体从光活化剂中接受电子时处于光致激发状态和/或还原状态的活性前体，通过电子转移转化为受益活性剂。电子受体最好不与光活化剂共价连接。还公开了一种制造受益活性剂的方法，包括将消费品组成物暴露于光线下，最好的波长大于约350nm。
• Photoactivators
  申请人：The Procter & Gamble Company

  公开号：US20150210960A1

  公开（公告）日：2015-07-30

  Photoactivators comprise a photoactive moiety and a hydrophilic moiety. The photoactivators preferably comprise less than about 35%, by weight of the photoactivator, of the photoactive moiety. The photoactivators can be activated to a photo-excited state by excitation with incident radiation of a wavelength between about 350 nm and 750 nm, preferably between about 350 nm and about 420 nm. The photoactivators further encompass those having certain chemical formulations.

  光活化剂包括光活性基团和亲水基团。光活化剂最好包含少于其重量的约35％的光活性基团。光活化剂可以通过激发波长在大约350nm和750nm之间（最好在大约350nm和大约420nm之间）的入射辐射而激活为光激发态。光活化剂还包括具有特定化学配方的化合物。
• Device and methods for applying compositions to fabric surfaces
  申请人：The Procter & Gamble Company

  公开号：US10156036B2

  公开（公告）日：2018-12-18

  A device and method for applying a material to a surface of a fabric. The device has a sensor and a microfluidic die. The device further includes a reservoir for containing a material to be deposited, and a CPU. The method includes providing information from the sensor about the surface to the CPU, which uses the information to identify where the material is to be deposited and/or how much to deposit.

  一种将材料涂抹到织物表面的设备和方法。该装置有一个传感器和一个微流控芯片。该装置还包括一个用于容纳待涂敷材料的储液器和一个中央处理器。该方法包括从传感器向中央处理器提供有关表面的信息，中央处理器利用这些信息来确定材料的沉积位置和/或沉积量。