2-Phenyl-6-fluoro-7-chloro-4H-1-benzopyran-4-one | 245549-09-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-Phenyl-6-fluoro-7-chloro-4H-1-benzopyran-4-one
• CAS: 245549-09-1
• 化学式: C₁₅H₈ClFO₂
• 分子量: 274.679
• InChiKey: FRDLDRRILYRTHA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.25
• 重原子数：
  19.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.21
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  哌啶 、 2-Phenyl-6-fluoro-7-chloro-4H-1-benzopyran-4-one 以68%的产率得到2-Phenyl-6-fluoro-7-piperidinyl-4H-1-benzopyran-4-one
  参考文献：
  名称：

  Flavone and xanthone derivatives related to fluoroquinolones

  摘要：

  A number of flavone and xanthone derivatives bearing some characteristic features of fluoroquinolones such as the fluorine atom and an ortho piperazine ring are described. The new compounds have been tested for possible cytotoxic and antimicrobial activities. Cytotoxicity of both groups of compounds is rather poor, while the antibacterial activity is restricted to xanthones. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00047-6
• 作为产物：
  描述：

  3-氯-4-氟苯酚 在 三氯化铝 、 硫酸 、 potassium carbonate 作用下， 以 溶剂黄146 、 丙酮 为溶剂， 反应 21.25h， 生成 2-Phenyl-6-fluoro-7-chloro-4H-1-benzopyran-4-one
  参考文献：
  名称：

  Flavone and xanthone derivatives related to fluoroquinolones

  摘要：

  A number of flavone and xanthone derivatives bearing some characteristic features of fluoroquinolones such as the fluorine atom and an ortho piperazine ring are described. The new compounds have been tested for possible cytotoxic and antimicrobial activities. Cytotoxicity of both groups of compounds is rather poor, while the antibacterial activity is restricted to xanthones. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(99)00047-6