1,1-Dimethyl-3-(1-naphthalen-1-yl-3-oxo-3-phenylpropyl)urea

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,1-Dimethyl-3-(1-naphthalen-1-yl-3-oxo-3-phenylpropyl)urea
• 英文别名: 1,1-dimethyl-3-(1-naphthalen-1-yl-3-oxo-3-phenylpropyl)urea
• 化学式: C₁₀H₁₉N₂O₄PolS
• 分子量: 346.4
• InChiKey: AVQSMXNOWAIDEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1-Dimethyl-3-(1-naphthalen-1-yl-3-oxo-3-phenylpropyl)urea 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 tert-butyl (2S)-5-(3-azidopropylamino)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoyl]amino]-5-oxopentanoate
  参考文献：
  名称：

  Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization

  摘要：

  The solid-phase synthesis of sultams from resin-bound amino acids is described. The sulfonylation of the resin-bound primary amines afforded the requisite secondary amines, after which the intramolecular Buchwald-Hartwig-type coupling forms the C-S bond. A final alkylation on the sulfonamides followed by cleavage provided the corresponding seven-membered sultams. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.055
• 作为产物：
  描述：

  丁氧羰基-甲硫氨酸(O)-OH 、 alkaline earth salt of/the/ methylsulfuric acid 在 N,N-二异丙基乙胺 、 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 1,1-Dimethyl-3-(1-naphthalen-1-yl-3-oxo-3-phenylpropyl)urea
  参考文献：
  名称：

  Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization

  摘要：

  The solid-phase synthesis of sultams from resin-bound amino acids is described. The sulfonylation of the resin-bound primary amines afforded the requisite secondary amines, after which the intramolecular Buchwald-Hartwig-type coupling forms the C-S bond. A final alkylation on the sulfonamides followed by cleavage provided the corresponding seven-membered sultams. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.01.055

文献信息

• An efficient synthesis of β-acylureas via a three-component, one-pot synthesis using TCS/ZnCl2
  作者：Tamer K. Khatab、Khairy A.M. El-Bayouki、Wahid M. Basyouni

  DOI：10.1016/j.tetlet.2011.01.066

  日期：2011.3

  A simple and efficient one-pot, three-component synthesis of new trisubstituted ureas containing diastereotopic protons is achieved via the reaction of aromatic aldehydes, aromatic ketones, and dimethyl cyanamide using a TCS/ZnCl2 reagent mixture at room temperature.

  通过在室温下使用TCS / ZnCl 2试剂混合物使芳族醛，芳族酮和二甲基氰胺反应，可以简单，高效地一锅三组分合成新的含非对映体质子的三取代脲。
• Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization
  作者：Wenteng Chen、Zhi Li、Lili Ou、Marc A. Giulianott、Richard A. Houghten、Yongping Yu

  DOI：10.1016/j.tetlet.2011.01.055

  日期：2011.3

  The solid-phase synthesis of sultams from resin-bound amino acids is described. The sulfonylation of the resin-bound primary amines afforded the requisite secondary amines, after which the intramolecular Buchwald-Hartwig-type coupling forms the C-S bond. A final alkylation on the sulfonamides followed by cleavage provided the corresponding seven-membered sultams. (c) 2011 Elsevier Ltd. All rights reserved.