6-氯-1,3-二甲基吡唑并[3,4-b]吡啶-5-甲醛 | 898911-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 中文名称: 6-氯-1,3-二甲基吡唑并[3,4-b]吡啶-5-甲醛
• 英文名称: 6-chloro-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridine-5-carbaldehyde
• 英文别名: 6-chloro-1,3-dimethylpyrazolo[3,4-b]pyridine-5-carbaldehyde
• CAS: 898911-34-7
• 化学式: C₉H₈ClN₃O
• mdl: MFCD08691397
• 分子量: 209.635
• InChiKey: GROJIEMGBWEVOY-UHFFFAOYSA-N

物化性质

• 沸点：
  365.4±37.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.222
• 拓扑面积：
  47.8
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  6-氯-1,3-二甲基吡唑并[3,4-b]吡啶-5-甲醛 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 生成 5-[[(4-chlorophenyl)amino]methyl]-N,N-diethyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-amine
  参考文献：
  名称：

  JP2015/54838

  摘要：

  公开号：
• 作为产物：
  描述：

  N-(1,3-二甲基-1H-吡唑-5-基)乙酰胺 在 三氯氧磷 、 N,N-二甲基甲酰胺 作用下， 反应 5.3h， 以43%的产率得到6-氯-1,3-二甲基吡唑并[3,4-b]吡啶-5-甲醛
  参考文献：
  名称：

  WO2006/73973

  摘要：

  公开号：

文献信息

• NOVEL PYRIMIDINE COMPOUNDS HAVING BENZYL (HETEROCYCLIC METHYL) AMINE STRUCTURE AND MEDICAMENT COMPRISING THE SAME
  申请人：OHGIYA Tadaaki

  公开号：US20090062306A1

  公开（公告）日：2009-03-05

  A compound represented by the following general formula (I), wherein R 1 , R 2 , R 3 , R 4 and R 5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R 6 represents an alkyl group, a cycloalkyl group and the like, R 7 and R 8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R 9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R 10 and R 11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

  通式（I）表示的化合物，其中R1、R2、R3、R4和R5表示氢原子、卤原子、低烷基基团等，R6表示烷基基团、环烷基基团等，R7和R8表示氢原子、低烷基基团、（低环烷基）（低烷基）基团等，R9表示氢原子、卤原子、低烷氧基团等，R10和R11表示氢原子、低烷基基团、低烷氧基团、卤代（低烷基）基团等，A表示由6到10个原子构成的杂环环，对胆固醇酯转移蛋白（CETP）具有强大的抑制活性。
• Novel benzylamine derivatives as CETP inhibitors
  申请人：Baruah Anima

  公开号：US20060178514A1

  公开（公告）日：2006-08-10

  The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

  本发明提供了包括新的苄胺化合物、含有苄胺化合物的组合物、制备苄胺化合物的方法以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的多种疾病或症状的方法等。
• Novel benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors
  申请人：Baruah Anima

  公开号：US20070015758A1

  公开（公告）日：2007-01-18

  The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

  本发明提供了新的苄基胺化合物，包括苄基胺化合物的组合物，制备苄基胺化合物的方法，以及使用苄基胺化合物治疗或预防与脂蛋白代谢有关的各种疾病或症状的方法。
• Substituted pyrimidine compounds and their utility as CETP inhibitors
  申请人：Kowa Company, Ltd.

  公开号：US07790737B2

  公开（公告）日：2010-09-07

  A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7 and R8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R10 and R11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).

  下列通式（I）所代表的化合物，其中R1、R2、R3、R4和R5代表氢原子、卤素原子、低级烷基等；R6代表烷基、环烷基等；R7和R8代表氢原子、低级烷基、（低级环烷基）（低级烷基）等；R9代表氢原子、卤素原子、低级烷氧基等；R10和R11代表氢原子、低级烷基、低级烷氧基、卤素（低级烷基）等；A代表由6到10个原子构成的杂环，具有对胆固醇酯转移蛋白（CETP）的强抑制活性。
• 5 - BENZYLAMINOMETHYL - 6 - AMINOPYRAZOLO [3, 4 -B] PYRIDINE DERIVATIVES AS CHOLESTERYL ESTER-TRANSFER PROTEIN (CETP) INHIBITORS USEFUL FOR THE TREATMENT OF ATHEROSCLEROSIS
  申请人：DR. REDDY'S LABORATORIES, LTD.

  公开号：US20140288072A1

  公开（公告）日：2014-09-25

  The present application relates to a series of substituted pyra-zolopyridin-6-amines having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein R, R 1 , R 2 , R a , R aa , R b and n are as defined herein. The present invention further relates to pharmaceutical compositions comprising compounds of formula (I). The compounds of this application are useful as CETP inhibitors for increasing HDL cholesterol and decreasing LDL cholesterol in a patient.

  本申请涉及一系列取代的吡唑吡啶-6-胺衍生物，其具有通式（I），包括其立体异构体和/或其药学上可接受的盐。其中R，R1，R2，Ra，Raa，Rb和n的定义如本文所述。本发明还涉及包含式（I）化合物的制药组合物。本申请的化合物可用作CETP抑制剂，以增加患者的高密度脂蛋白胆固醇并降低低密度脂蛋白胆固醇。