(+/-)-4-methylaminocycloheptanone | 82323-65-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+/-)-4-methylaminocycloheptanone
• 英文别名: 4-(methylamino)cycloheptanone；physoperuvine；4-(methylamino)cycloheptan-1-one
• CAS: 82323-65-7
• 化学式: C₈H₁₅NO
• mdl: MFCD19218629
• 分子量: 141.213
• InChiKey: SMAUMNRVOPPBNC-UHFFFAOYSA-N

物化性质

• 沸点：
  230.5±33.0 °C(Predicted)
• 密度：
  0.95±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-)-4-methylaminocycloheptanone 生成 (+/-)-N-benzoyl-4-methylaminocycloheptanone
  参考文献：
  名称：

  physperuvine的结构和合成：（±）-3-和（+）-4-甲基氨基环庚酮的n-苯甲酰基衍生物的x射线晶体和分子结构

  摘要：

  单晶X射线分析确定了（±）-N-苯甲酰基-3-甲基氨基环庚酮[（±）- ]和（+）- N-苯甲酰基-4-甲基氨基环庚酮[（±）]。拆分（±）-[4-甲基氨基环庚酮α1-羟基托烷]以产生（+）-对映体。在所有方面，通过二-对甲苯甲酰基-（+）-酒石酸盐可实现与天然（+）-紫杉烷的游离碱相同。

  DOI：

  10.1016/s0040-4020(01)91114-7
• 作为产物：
  描述：

  N-nitrosomethyluretane 、 4-甲氨基环己酮 在 sodium carbonate 作用下， 以71%的产率得到(+/-)-4-methylaminocycloheptanone
  参考文献：
  名称：

  Structure of physoperuvine

  摘要：

  DOI：

  10.1021/jo00140a002

文献信息

• POLYMER, RESIST COMPOSITION, AND PATTERN FORMING PROCESS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20160229940A1

  公开（公告）日：2016-08-11

  A polymer comprising recurring units having an acid generator bound to the backbone, and recurring units having an optionally acid labile group-substituted carboxyl group and/or recurring units having an optionally acid labile group-substituted hydroxyl group is obtained by polymerizing corresponding monomers in a solution of a non-polymerizable compound containing a nitrogen atom to which an acid labile group is bound. This prevents deprotection reaction of the acid labile group in the case of positive resist-forming polymer or crosslinking reaction in the case of negative resist-forming polymer.
• METHOD FOR PRODUCING POLYMER
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20170097567A1

  公开（公告）日：2017-04-06

  A polymer comprising recurring units having an acid generator bound to the backbone, and recurring units having an optionally acid labile group-substituted carboxyl group and/or recurring units having an optionally acid labile group-substituted hydroxyl group is obtained by polymerizing corresponding monomers in a solution of a non-polymerizable compound containing a nitrogen atom to which an acid labile group is bound. This prevents deprotection reaction of the acid labile group in the case of positive resist-forming polymer or crosslinking reaction in the case of negative resist-forming polymer.
• Structure of physoperuvine
  作者：A. R. Pinder

  DOI：10.1021/jo00140a002

  日期：1982.9
• Structure and synthesis of physoperuvine: x-ray crystal and molecular structures of the n-benzoyl derivatives of (±)-3- and (+)-4-methylaminocycloheptanone
  作者：Andrew T. Mcphail、A. Reginald Pinder

  DOI：10.1016/s0040-4020(01)91114-7

  日期：1984.1

  Single-crystal X-ray analyses have defined the structures and solid-state conformations of (±)-N-benzoyl-3-methylaminocycloheptanone [(±)-]and (+)-N-benzoyl-4-methylaminocycloheptanone [(±)]. Resolution of (±)-[4- methylaminocycloheptanone α 1-hydroxytropane]to yield the (+)-enantiomer. Identical in all respects with the free base from natural (+)-physoperuvine, was achieved via the di-p-toluoyl-(+)-tartrate

  单晶X射线分析确定了（±）-N-苯甲酰基-3-甲基氨基环庚酮[（±）- ]和（+）- N-苯甲酰基-4-甲基氨基环庚酮[（±）]。拆分（±）-[4-甲基氨基环庚酮α1-羟基托烷]以产生（+）-对映体。在所有方面，通过二-对甲苯甲酰基-（+）-酒石酸盐可实现与天然（+）-紫杉烷的游离碱相同。