23-Bromtricosansaeure | 61658-19-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 23-Bromtricosansaeure
• 英文别名: Tricosanoic acid, 23-bromo-；23-bromotricosanoic acid
• CAS: 61658-19-3
• 化学式: C₂₃H₄₅BrO₂
• 分子量: 433.513
• InChiKey: LGMXBXJPTVHNLK-UHFFFAOYSA-N

物化性质

• 熔点：
  86-87 °C(Solv: ligroine (8032-32-4))
• 沸点：
  511.7±23.0 °C(Predicted)
• 密度：
  1.042±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  26
• 可旋转键数：
  22
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  23-Bromtricosansaeure 在 diborane(6) 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 N,N-bis(23-bromotricosyl)-28,29-dimethoxybicyclo[25.3.1]hentriaconta-1(30),27(31),28-trien-31-amine
  参考文献：
  名称：

  Isele,G.L.; Vuano,B.M., Justus Liebigs Annalen der Chemie, 1976, p. 1903 - 1913

  摘要：

  DOI：
• 作为产物：
  描述：

  1-morpholinocyclododecene 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 生成 23-Bromtricosansaeure
  参考文献：
  名称：

  Isele,G.L.; Vuano,B.M., Justus Liebigs Annalen der Chemie, 1976, p. 1903 - 1913

  摘要：

  DOI：

文献信息

• CELL ADHESIVE MATERIAL FOR BIOLOGICAL TISSUE
  申请人：Sanyo Chemical Industries, Ltd.

  公开号：EP2636415A1

  公开（公告）日：2013-09-11

  An object of the present invention is to provide a cell-adhesive material for biological tissues, in which the surface of a material for biological tissues (particularly metallic material) is modified strongly with a large amount of a cell-adhesive artificial peptide (P) that retains a biological activity. The present invention provides a cell-adhesive material for biological tissues including a cell-adhesive artificial peptide (P) and a material for biological tissues, wherein the cell-adhesive artificial peptide (P) is immobilized on the surface of the material for biological tissues through an electrochemical reaction. The cell-adhesive artificial peptide (P) is preferably a peptide (P1) that is synthesized by a genetic recombinant microorganism and has at least one cell-adhesive minimal amino acid sequence (X) in one molecule. The number of the cell-adhesive minimal amino acid sequences (X) in one molecule of the polypeptide (P1) is preferably 3 to 50.

  本发明的目的是提供一种用于生物组织的细胞粘附材料，其中生物组织材料（特别是金属材料）的表面被大量保持生物活性的细胞粘附人工肽（P）强烈修饰。 本发明提供了一种生物组织细胞粘附材料，包括细胞粘附人工肽（P）和生物组织材料，其中细胞粘附人工肽（P）通过电化学反应固定在生物组织材料表面。细胞粘附性人工多肽（P）最好是由基因重组微生物合成的多肽（P1），在一个分子中至少有一个细胞粘附性最小氨基酸序列（X）。在多肽（P1）的一个分子中，细胞粘附性最小氨基酸序列（X）的数量最好为 3 至 50 个。
• DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS-THERAPEUTIC SAMS
  申请人：Agrawal C. Mauli

  公开号：US20090123516A1

  公开（公告）日：2009-05-14

  Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.
• US9463262B2
  申请人：——

  公开号：US9463262B2

  公开（公告）日：2016-10-11
• [EN] DRUG DELIVERY FROM IMPLANTS USING SELF-ASSEMBLED MONOLAYERS - THERAPEUTIC SAMS<br/>[FR] LIBERATION DE MEDICAMENTS PAR DES IMPLANTS COMPRENANT DES MONOCOUCHES AUTO-ASSEMBLEES (SAM) SAM THERAPEUTIQUES
  申请人：UNIV TEXAS

  公开号：WO2007019478A2

  公开（公告）日：2007-02-15

  [EN] Disclosed are medical devices comprising one or more surfaces, one or more SAM molecules attached to the one or more surfaces of the medical device, and one or more therapeutic agents attached to the one or more self-assembled monolayer molecules. Also disclosed are medical devices comprising one or more surfaces, one or more self-assembled monolayer molecules attached to the one or more surfaces of the medical device, one or more linkers comprising a first functional group and a second functional group, the first functional group attached to the self-assembled monolayer molecule and a therapeutic agent attached to the second functional group. The therapeutic agent may be attached to the SAM molecule via a linker. The present invention also concerns methods of administering a therapeutic agent to a subject, comprising contacting the subject with one of the medical devices set forth herein.
  [FR] L'invention concerne des dispositifs médicaux comprenant une ou plusieurs surfaces, une ou plusieurs molécules SAM attachées à une ou plusieurs surfaces du dispositif médical, et un ou plusieurs agents thérapeutiques fixés sur les molécules de la ou des monocouches auto-assemblées. L'invention concerne en outre des dispositifs médicaux comprenant une ou plusieurs surfaces, une ou plusieurs molécules de monocouche auto-assemblée fixées à la surface ou aux surfaces du dispositif médical, un ou plusieurs lieurs comprenant un premier groupe fonctionnel et un second groupe fonctionnel, le premier groupe fonctionnel étant attaché à la molécule de la monocouche auto-assemblée, et un agent thérapeutique attaché au second groupe fonctionnel. L'agent thérapeutique peut être fixé sur la molécule SAMS par l'intermédiaire d'un lieur. L'invention porte également sur des procédés d'administration d'un agent thérapeutique à un sujet consistant appliquer un dispositif médical du type décrit à un sujet.
• Isele,G.L.; Vuano,B.M., Justus Liebigs Annalen der Chemie, 1976, p. 1903 - 1913
  作者：Isele,G.L.、Vuano,B.M.

  DOI：——

  日期：——