3,5-二甲基呋喃-2,4(3H,5H)-二酮 | 5460-81-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 中文名称: 3,5-二甲基呋喃-2,4(3H,5H)-二酮
• 英文名称: 3,5-dimethyl-furan-2,4-dione
• 英文别名: 3,5-Dimethyl-furan-2,4-dion；3,5-dimethyl-2,4(3H,5H)-furandione；α,γ-Dimethyl-tetronsaeure；3,5-Dimethyl-tetronsaeure；2,4(3H,5H)-Furandione, 3,5-dimethyl-；3,5-dimethyloxolane-2,4-dione
• CAS: 5460-81-1
• 化学式: C₆H₈O₃
• 分子量: 128.128
• InChiKey: JZLFAWGGYBKIQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2932190090

反应信息

• 作为产物：
  描述：

  3,5-dimethyl-2,4-dioxo-tetrahydro-furan-3-carboxylic acid ethyl ester 在 硫酸 作用下， 生成 3,5-二甲基呋喃-2,4(3H,5H)-二酮
  参考文献：
  名称：

  Ring Closure in the Tetronic Acid Series¹

  摘要：

  DOI：

  10.1021/ja01526a046

文献信息

• Method for reducing a susceptibility to tumor formation induced by 3-deoxyglucosone and precursors thereof
  申请人：Brown R. Truman

  公开号：US20060089316A1

  公开（公告）日：2006-04-27

  Disclosed are methods of using various compounds, which are known to bind to 3-deoxyglucosone (3DG) or precursors thereof, in order to reduce a susceptibility to tumor formation and/or to prevent or delay onset of tumor formation induced by 3DG and its precursors. Also disclosed is the reduction of 3DG levels in high fructose corn syrop so that the high fructose corn syrup is less likely to induce tumor formation.

  公开了使用各种已知与3-脱氧葡萄糖酮（3DG）或其前体结合的化合物的方法，以减少对肿瘤形成的易感性和/或预防或延迟由3DG及其前体诱导的肿瘤形成。还公开了降低高果糖玉米糖浆中3DG水平的方法，以使高果糖玉米糖浆不太可能诱导肿瘤形成。
• NOVEL CARBONYL REDUCTASE, GENE THEREOF AND METHOD OF USING THE SAME
  申请人：KANEKA CORPORATION

  公开号：EP1553170A1

  公开（公告）日：2005-07-13

  The present invention provides a novel polypeptide efficiently forming (R)-N-benzyl-3-pyrrolidinol, a polynucleotide coding for said polypeptide, and use of the same. The present invention relates to a polypeptide having the following physical and chemical properties (1) to (4): (1) activity: acting on N-benzyl-3-pyrrolidinone with NADH or NADPH as a coenzyme, to form (R)-N-benzyl-3-pyrrolidinol; (2) optimum pH for activity: 5.5 to 6.0; (3) optimum temperature for activity: 50°C to 55°C; (4) molecular weight: about 55,000 as determined by gel filtration analysis, about 28,000 as determined by SDS polyacrylamide gel electrophoresis analysis. The present invention also relates to a polypeptide comprising the amino acid sequence shown under SEQ ID NO:1 in the sequence listing, a polynucleotide coding for said polypeptide, and a transformant producing said polypeptide at high levels.

  本发明提供了一种可有效形成(R)-N-苄基-3-吡咯烷醇的新型多肽、编码所述多肽的多核苷酸及其用途。 本发明涉及一种具有以下物理和化学特性（1）至（4）的多肽： (1) 活性：以 NADH 或 NADPH 为辅酶作用于 N-苄基-3-吡咯烷酮，生成 (R)-N-苄基-3-吡咯烷醇； (2) 活性的最佳 pH 值：5.5 至 6.0； (3) 活性的最佳温度：50°C 至 55°C； (4) 分子量：凝胶过滤分析测定约为 55 000，SDS 聚丙烯酰胺凝胶电泳分析测定约为 28 000。 本发明还涉及一种多肽，其包含序列表中 SEQ ID NO:1 所示的氨基酸序列、编码所述多肽的多核苷酸以及高水平生产所述多肽的转化体。
• CURABLE COMPOSITION AND CURED OBJECT FORMED THEREFROM
  申请人：Kaneka Corporation

  公开号：EP2388297A1

  公开（公告）日：2011-11-23

  The present invention aims to provide a curable composition that exhibits excellent curability without containing an organotin curing catalyst, which is known to be toxic, gives a cured product that does not have surface discoloration even after being exposed to the atmosphere and ultraviolet light for a long time, and has no adverse influence on the environment; and a cured product thereof. The non-organotin curable composition comprises: (A) an organic polymer having a reactive silyl group; (B) an amidine compound; and (C) a chelating agent having a carbonyl group and/or a salt of the chelating agent.

  本发明旨在提供一种固化组合物，该组合物不含已知有毒的有机锡固化催化剂，具有极佳的固化性，即使长期暴露于大气和紫外线中也不会产生表面褪色现象，并且不会对环境产生不利影响；及其固化产品。非有机锡固化组合物包括：(A) 具有活性硅基的有机聚合物；(B) 氨基胍化合物；和 (C) 具有羰基的螯合剂和/或螯合剂的盐。
• Ketene Acetals. XXVII. The Bromination of Various Ketene Acetals
  作者：S. M. McElvain、William R. Davie

  DOI：10.1021/ja01127a057

  日期：1952.4
• THE OXIDATION OF TETRONIC ACIDS. I. STRUCTURAL CRITERIA FOR THE FORMATION OF 1,2-DIKETONES
  作者：EVANS B. REID、ROBERT B. FORTENBAUGH、HELEN R. PATTERSON

  DOI：10.1021/jo01149a021

  日期：1950.5