3-cyclohexyl-5-(p-aminophenyl)-1-(p-methylphenyl)imidazolidine-2,4-dione | 1366088-17-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-cyclohexyl-5-(p-aminophenyl)-1-(p-methylphenyl)imidazolidine-2,4-dione
• CAS: 1366088-17-6
• 化学式: C₂₂H₂₅N₃O₂
• 分子量: 363.459
• InChiKey: BSTVPHYTIVBNJB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.42
• 重原子数：
  27.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  66.64
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  对氯苯氧乙酸 、 异氰环已烷 、 3-cyclohexyl-5-(p-aminophenyl)-1-(p-methylphenyl)imidazolidine-2,4-dione 、 苯甲醛 以 甲醇 为溶剂， 反应 0.5h， 以69%的产率得到N-cyclohexyl 2-{N-(p-chlorophenoxyacetyl)-N-[4-(3-cyclohexyl-2,4-dioxo-1-(p-tolyl)imidazolidin-5-yl)phenylamino]}-2-phenylacetamide
  参考文献：
  名称：

  A diastereoselective synthesis of pseudopeptidic hydantoins by an Ugi/cyclization/Ugi sequence

  摘要：

  A diastereoselective synthesis of helix-forming pseudopeptidic hydantoins by an Ugi 4CC/cyclization/reduction/Ugi 4CC sequence of reactions, giving mainly the L-adduct when benzoic acids were used, is described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.01.073
• 作为产物：
  描述：

  N-cyclohexyl-2-[N-(p-methylphenyl)-N-(trichloroacetyl)amino]-2-(p-nitrophenyl)acetamide 在 sodium ethanolate 、 铁粉 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 0.58h， 生成 3-cyclohexyl-5-(p-aminophenyl)-1-(p-methylphenyl)imidazolidine-2,4-dione
  参考文献：
  名称：

  A diastereoselective synthesis of pseudopeptidic hydantoins by an Ugi/cyclization/Ugi sequence

  摘要：

  A diastereoselective synthesis of helix-forming pseudopeptidic hydantoins by an Ugi 4CC/cyclization/reduction/Ugi 4CC sequence of reactions, giving mainly the L-adduct when benzoic acids were used, is described. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.01.073

文献信息

• A diastereoselective synthesis of pseudopeptidic hydantoins by an Ugi/cyclization/Ugi sequence
  作者：María Sañudo、María García-Valverde、Stefano Marcaccini、Tomás Torroba

  DOI：10.1016/j.tet.2012.01.073

  日期：2012.3

  A diastereoselective synthesis of helix-forming pseudopeptidic hydantoins by an Ugi 4CC/cyclization/reduction/Ugi 4CC sequence of reactions, giving mainly the L-adduct when benzoic acids were used, is described. (C) 2012 Elsevier Ltd. All rights reserved.