2,3-dimethylhydroquinone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,3-dimethylhydroquinone
• 英文别名: 2,3-Dimethylcyclohexa-2,5-diene-1,4-diol
• 化学式: C₈H₁₂O₂
• 分子量: 140.182
• InChiKey: LYUFISBDGKDSAI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-dimethylhydroquinone 在 盐酸 、 硝酸 作用下， 反应 1.0h， 以25%的产率得到2,3-dichloro-5,6-dimethyl-1,4-benzoquinone
  参考文献：
  名称：

  Synthesis and antifungal activity of 6-hydroxycinnolines

  摘要：

  6-Hydroxycinnolines 2 and cyclohexa-2,5-diene-1,4-dione derivatives 6 were synthesized and tested for in vitro antifungal activity against Candida and Aspergillus species. 6-Hydroxycinnolines 2 showed, in general, more potent antifungal activity against Candida species than the other cyclohexa-2,5-diene-1,4-diones. The results Suggest that 6-hydroxycinnolines would be potent antifungal agents. (C) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.01.005

文献信息

• BIOLOGICALLY ACTIVE COMPOUNDS SPECIFICALLY DELIVERED INTO MITOCHONDRIA
  申请人：MITOTECH SA

  公开号：US20160200749A1

  公开（公告）日：2016-07-14

  This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of biologically active substances into mitochondria, driven by proton electro-chemical potential in the mitochondria. This invention also relates to the method to affect an organism by the targeted delivery of biologically active compounds to mitochondria. The invention can be useful in treatment of diseases or disorders associated with not normal functioning of mitochondria, in particular diseases associated with increased production of free radicals and reactive oxygen species.

  该发明涉及生物学和医学领域，特别是可以用于制备药物组合物，以便通过线粒体内的质子电化学势来实现对生物活性物质的定向输送。该发明还涉及一种通过将生物活性化合物定向输送到线粒体来影响生物体的方法。该发明可用于治疗与线粒体不正常功能相关的疾病或障碍，特别是与自由基和活性氧物质过度产生相关的疾病。
• Aerobic Oxidation of Dihydroxyarenes Substrates Catalyzed by Polymer-Supported RuII-Pheox/Silica-Gel: A Beneficial Route for Purification of Industrial Water
  作者：Abdel-Moneim Abu-Elfotoh

  DOI：10.2174/1570178617666210108114219

  日期：2022.3

  A broad class of dihydroxyarenes were easily oxidized by aerobic oxygen to quinone products in excellent yields under the catalytic effect of polymer-supported RuII-Pheox/silica-gel catalyst. By using this combined catalyst, hydroquinone and catechol derivatives with electron-donating groups were easily oxidized by molecular oxygen to quinone products in 90% to >99% yield, while in the case of electron-withdrawing group, only 70% was obtained. The biologically useful 1,4-Naphthoqinone products were obtained in 83% to 90%. The catalyst was easily obtained and reused many times without a significant decrease in reactivity. Interestingly, a sample of industrial water contaminated with phenolic compounds was subjected to aerobic oxidation by using this catalyst, and the resultant quinones were detected within one day and the catalyst was removed and reused several times with different contaminating samples with the same efficiency. Other catalytic oxidations by using this promising catalyst were investigated.

  摘要：一种广泛的二羟基芳烃类化合物在聚合物支持的RuII-Pheox/硅胶催化剂的催化下，容易被氧气氧化为醌产物，产率极高。通过使用这种联合催化剂，带有电子供体基团的氢醌和邻苯二酚衍生物可以在分别达到90%到>99%的收率下被分子氧氧化为醌产物，而在带有电子吸引基团的情况下，只能得到70%的收率。生物学上有用的1,4-萘醌产物的收率在83%到90%之间。该催化剂易于获得并多次重复使用而不会显著降低反应性。有趣的是，使用该催化剂对含酚类化合物的工业废水进行氧化处理，结果在一天内检测到产生的醌类物质，并且该催化剂可以被移除并多次重复使用以相同的效率处理不同的污染样品。使用这种有前途的催化剂进行其他催化氧化反应也得到了研究。
• Al-Khayat, Isam; Dean, Francis M.; France, Steven N., Journal of the Chemical Society. Perkin transactions I, 1985, p. 1301 - 1310
  作者：Al-Khayat, Isam、Dean, Francis M.、France, Steven N.、Matkin, David A.、Orabi, Mohamed O. A.、et al.

  DOI：——

  日期：——
• Synthesis and antifungal evaluation of pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones
  作者：Chung-Kyu Ryu、Joo Hee Yoon、Ae Li Song、Hyun Ah Im、Ji Young Kim、Aram Kim

  DOI：10.1016/j.bmcl.2011.10.092

  日期：2012.1

  Pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among them tested, many compounds showed good antifungal activity. The results suggest that pyrido[1,2-a]indole-1,4-diones and benzo[f]pyrido[1,2-a]indole-6,11-diones would be potent antifungal agents. (C) 2011 Elsevier Ltd. All rights reserved.
• METHOD OF TREATING ORGANISM BY BIOLOGICALLY ACTIVE COMPOUNDS SPECIFICALLY DELIVERED INTO MITOCHONDRIA, PHARMACEUTICAL COMPOSITION REQUIRED FOR THE USE OF THE METHOD AND A COMPOUND APPLICABLE FOR THIS PURPOSE
  申请人：Skulachev Vladimir Petrovich

  公开号：US20080176929A1

  公开（公告）日：2008-07-24

  This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of biologically active substances into mitochondria, driven by proton electro-chemical potential in the mitochondria. This invention also relates to the method to affect an organism by the targeted delivery of biologically active compounds to mitochondria. The invention can be useful in treatment of diseases or disorders associated with not normal functioning of mitochondria, in particular diseases associated with increased production of free radicals and reactive oxygen species.