(3R,4S)-3,4-二甲基环戊酮 | 19550-72-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (3R,4S)-3,4-二甲基环戊酮
• 英文名称: cis-3,4-dimethylcyclopentanone
• 英文别名: (3R^*,4S^*)-3,4-dimethylcyclopentanone；meso-3,4-dimethylcyclopentanone；(3S,4R)-3,4-Dimethyl-cyclopentanone；3r,4c-Dimethyl-cyclopentan-1-on；cis-Dimethyl-3,4-cyclopentanon；(3S,4R)-3,4-dimethylcyclopentan-1-one
• CAS: 19550-72-2
• 化学式: C₇H₁₂O
• 分子量: 112.172
• InChiKey: ZMGMYCHEWPVBEL-OLQVQODUSA-N

物化性质

• 沸点：
  154.8±8.0 °C(Predicted)
• 密度：
  0.895±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2914299000

反应信息

• 作为反应物：
  描述：

  (3R,4S)-3,4-二甲基环戊酮 在 selenium(IV) oxide 、 双氧水 作用下， 以 叔丁醇 为溶剂， 反应 7.0h， 生成 (1R,2R,3R)-2,3-Dimethyl-cyclobutanecarboxylic acid
  参考文献：
  名称：

  Granger,R. et al., Bulletin de la Societe Chimique de France, 1969, p. 2801 - 2806

  摘要：

  DOI：
• 作为产物：
  描述：

  meso-3,4-Dimethyl-adipinsaeure 在 barium dihydroxide 作用下， 以75%的产率得到(3R,4S)-3,4-二甲基环戊酮
  参考文献：
  名称：

  法老的光学信息，法老的蚂蚁的尾信息素的合成。

  摘要：

  法呢醛[（6 E，10 Z）-3,4,7,11-四甲基-6，（3 S，4 R）-（+）-和（3 R，4 S）-（-）-对映异构体合成了10-tride-cadienal。前者的生物活性可与从法老莫诺菌中分离的天然信息素相提并论。

  DOI：

  10.1016/0040-4020(82)85108-9

文献信息

• Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
  申请人：——

  公开号：US20020019411A1

  公开（公告）日：2002-02-14

  Dipeptidyl peptidase IV (DP 4) inhibiting compounds are provided having the formula 1 where x is 0 or 1 and y is 0 or 1 (provided that x=1 when y=0 and x=0 when y=1); n is 0 or 1; X is H or CN; and wherein R 1 , R 2 , R 3 and R 4 are as described herein. A method is also provided for treating diabetes and related diseases, especially Type II diabetes, and other diseases as set out herein, employing such DP 4 inhibitor or a combination of such DP 4 inhibitor and one or more of another antidiabetic agent such as metformin, glyburide, troglitazone, pioglitazone, rosiglitazone and/or insulin and/or one or more of a hypolipidemic agent and/or anti-obesity agent and/or other therapeutic agent.

  提供了具有公式1的抑制二肽基肽酶IV（DP 4）的化合物，其中x为0或1，y为0或1（前提是当y=0时，x=1，当y=1时，x=0）；n为0或1；X为H或CN；其中R1、R2、R3和R4如本文所述。还提供了一种治疗糖尿病和相关疾病，特别是II型糖尿病以及本文中列出的其他疾病的方法，使用这种DP 4抑制剂或这种DP 4抑制剂与另一种或多种抗糖尿病药物（如二甲双胍、格列本脲、曲格列酮、吡格列酮、罗格列酮和/或胰岛素）的组合，以及一种或多种降脂药物和/或抗肥胖药物和/或其他治疗药物。
• Synthesis of optically active forms of faranal, the trail pheromone of Pharaoh's ant
  作者：Kenji Mori、Hiraki Ueda

  DOI：10.1016/0040-4020(82)85108-9

  日期：1982.1

  Both (3S,4R)-(+)- and (3R,4S)-(−)-enantiomers of faranal [(6E,10Z)-3,4,7,11-tetramethyl-6,10-tride- cadienal] were synthesized. The former was comparable in bioactivity with that of the natural trail pheromone isolated from Monomorium pharaonis.

  法呢醛[（6 E，10 Z）-3,4,7,11-四甲基-6，（3 S，4 R）-（+）-和（3 R，4 S）-（-）-对映异构体合成了10-tride-cadienal。前者的生物活性可与从法老莫诺菌中分离的天然信息素相提并论。
• Synthesis of optically active forms of faranal, the trail pheromone of pharaoh's ant
  作者：Kenji Mori、Hiraki Ueda

  DOI：10.1016/0040-4039(81)80126-8

  日期：1981.1

  (3S 4R)-(+)-Faranal and its antipode were synthesized. The former was comparable in bioactivity with that of the natural pheromone.

  合成了（3S 4R）-（+）-芳烃及其对映体。前者的生物活性与天然信息素相当。
• [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSES HETEROCYCLIQUES ET PROCEDES D'UTILISATION DE CEUX-CI
  申请人：MERCK & CO INC

  公开号：WO2001016121A1

  公开（公告）日：2001-03-08

  In accordance with the present invention, there are provided novel class of heterocyclic compounds and methods of use thereof. Compounds of the invention contain a substituted, unsaturated five, six or seven membered heterocyclic ring that includes at least one nitrogen atom and at least one carbon atom. At a ring position adjacent to a ring nitrogen atom, the heterocyclic ring has at least one substituent which includes a moiety, linked to the heterocyclic ring via an alkylene moiety, an alkynylene moiety or an azo group. Invention compounds are capable of a wide variety of uses including modulating physiological processes by functioning as agonists and antagonists of receptors in the nervous system, as insecticides, and as fungicides. The invention further provides methods of modulating the activity of excitatory amino acid receptors using a specifically defined class of heterocyclic compounds including the novel compounds referred to above. In one embodiment, there are provided methods of modulating metabotropic glutamate receptors. The present invention also discloses methods of treating disease using heterocyclic compounds. The invention further discloses methods of preventing disease conditions related to diseases of the pulmonary system, diseases of the nervous system, diseases of the cardiovascular system, diseases of the gastrointestinal system, diseases of the endocrine system, diseases of the exocrine system, diseases of the skin, cancer and diseases of the ophthalmic system. The invention also discloses pharmaceutically acceptable salt forms of the above-described heterocyclic compounds.

  根据本发明，提供了一类新型的杂环化合物及其使用方法。该发明的化合物包含一个取代的、不饱和的五、六或七元杂环环，其中至少包含一个氮原子和至少一个碳原子。在靠近环氮原子的环位置上，杂环环有至少一个取代基，包括一个官能团，通过烷基官能团、炔基官能团或偶氮基团连接到杂环环上。发明的化合物能够广泛应用，包括通过作为神经系统受体的激动剂和拮抗剂来调节生理过程，作为杀虫剂和杀菌剂。本发明还提供了使用特定定义的杂环化合物类来调节兴奋性氨基酸受体活性的方法，包括上述新型化合物。在一种实施例中，提供了调节代谢性谷氨酸受体的方法。本发明还揭示了使用杂环化合物治疗疾病的方法。本发明还揭示了预防与肺系统疾病、神经系统疾病、心血管系统疾病、胃肠系统疾病、内分泌系统疾病、外分泌系统疾病、皮肤疾病、癌症和眼科系统疾病相关的疾病状态的方法。本发明还揭示了上述杂环化合物的药物可接受的盐形式。
• SPIROIMIDAZOLONE DERIVATIVE
  申请人：Esaki Toru

  公开号：US20120270838A1

  公开（公告）日：2012-10-25

  The present invention relates to a compound represented by the following formula (1): wherein W, X, Y, R 1 , R 2 , R 33 , R 34 , m and n are as defined in the claims, or a pharmacologically acceptable salt thereof.

  本发明涉及下式（1）所表示的化合物：其中W、X、Y、R1、R2、R33、R34、m和n如权利要求所定义，或其药学上可接受的盐。

表征谱图