3,5-bis(3-buten-1-oxy)benzyl alcohol | 221208-75-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,5-bis(3-buten-1-oxy)benzyl alcohol
• 英文别名: 3,5-bis(3-buten-1-yloxy)benzyl alcohol；3,5-bis[(but-3-en-1-yl)oxy]benzylalcohol；3,5-di(3-buten-1-yloxy)benzyl alcohol；[3,5-Bis(but-3-enoxy)phenyl]methanol
• CAS: 221208-75-9
• 化学式: C₁₅H₂₀O₃
• 分子量: 248.322
• InChiKey: NKRVAWPRZNYVBS-UHFFFAOYSA-N

物化性质

• 沸点：
  386.3±42.0 °C(Predicted)
• 密度：
  1.032±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,5-bis(3-buten-1-oxy)benzyl alcohol 在 lithium aluminium tetrahydride 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成 3,5-bis{3,5-bis[3,5-bis(3-buten-1-oxy)benzyloxy]benzyloxy}benzyl alcohol
  参考文献：
  名称：

  树枝状大分子内部的分子印迹

  摘要：

  能够结合卟啉的合成宿主已通过混合共价非共价印迹过程产生，其中在交联的树枝状聚合物中产生单个结合位点。使用 5,10,15,20-四（4-羟基苯基）卟啉和 5,10,15,20-四（3,5-二羟基苯基）卟啉作为模板，制备了两种合成宿主。这两个模板分别用含有高烯丙基端基的第四代和第三代 Fréchet 型树突酯化。使用 Grubbs 的 I 型催化剂 RuCl(2)(P(C(6)H(5))(3))(2)(CHCH(2)C (6)H(5))，提供广泛的树突间交联。卟啉核心的水解去除提供了印迹宿主，其通过紫外-可见分光光度法滴定和尺寸排阻色谱研究了结合卟啉与各种外围取代基的能力。结果表明印迹位点的高产率显示出结合能够形成至少四个氢键的卟啉的高选择性，但只有中等程度的形状选择性。

  DOI：

  10.1021/ja0357240
• 作为产物：
  描述：

  3,5-二羟基苯甲酸甲酯 在 lithium aluminium tetrahydride 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成 3,5-bis(3-buten-1-oxy)benzyl alcohol
  参考文献：
  名称：

  Enhanced Catalytic Activity in Suzuki–Miyaura Couplings by Shell Crosslinked Pd Nanoparticles from Alkene-terminated Phosphine Dendron-stabilized Pd Nanoparticles

  摘要：

  新型末端为烯烃的膦树状大分子保护的钯纳米颗粒（NPs）已合成，其钯纳米颗粒的烯烃 metathesis 聚合反应导致了钯纳米颗粒的壳层交联，且未发生钯纳米颗粒的聚集。在保护配体表面引入交联结构，增强了钯纳米颗粒在 Suzuki-Miyaura 偶联反应中的催化活性。

  DOI：

  10.1246/cl.2012.1700

文献信息

• [EN] CHEMICAL COMPOUNDS FOR COATING OF NANOSTRUCTURES<br/>[FR] COMPOSÉS CHIMIQUES POUR LE REVÊTEMENT DE NANOSTRUCTURES
  申请人：SPAGO NANOMEDICAL AB

  公开号：WO2018130713A1

  公开（公告）日：2018-07-19

  The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core, wherein the aromatic core is a benzene ring or a biphenyl; the carbocyclic, non-aromatic core is a 5 to 7 membered ring. The core has covalently attached thereto: at least two anchoring groups, each anchoring group comprising an activated silane group, wherein the anchoring groups have the following general formula –A-(CH2)nSiY3 wherein A is a covalent bond or O, "n" is an integer from 1 to 3, and Y is independently a methoxy group or an ethoxy group; and at least one hydrophilic group extending from the core, the hydrophilic group comprising one or more hydrophilic polymer residues with a molecular composition of (aO+bN)/(cC+dS+eSi+fP) > 0.3 where a, b, c, d, e and f are the mol percentage of oxygen (O), nitrogen (N), carbon (C), sulfur (S), silicon (Si) and phosphorus (P), respectively; wherein the hydrophilic polymer residue(s) is(are) selected, independently of each other if more than one hydrophilic group is present, from –(O-CH2-CH2)m-OX, wherein X is CH3 or H, and "m" is an integer from 6 to 25; and the number of hydrophilic groups extending from the core is from one to the number of ring structures in the core. The present invention also relates to compositions comprising the chemical compound and nanostructures comprising residues of the chemical compound as well as the use of such nanostructures. Furthermore, the invention relates to methods for obtaining the chemical compounds and the nanostructures.

  本申请涉及一种化合物，包括一个芳香核或一个碳环非芳香核，其中所述芳香核是苯环或联苯；所述碳环非芳香核是一个含有5至7个成员的环。核上共价连接有：至少两个锚定基团，每个锚定基团包括一个活化硅烷基团，其中锚定基团具有以下一般式-A-(CH2)nSiY3，其中A是一个共价键或O，"n"是1至3之间的整数，Y独立地是一个甲氧基或一个乙氧基；以及至少一个从核心延伸的亲水基团，所述亲水基团包括一个或多个亲水聚合物残基，其分子组成为(aO+bN)/(cC+dS+eSi+fP) > 0.3，其中a、b、c、d、e和f分别是氧（O）、氮（N）、碳（C）、硫（S）、硅（Si）和磷（P）的摩尔百分比；其中亲水聚合物残基独立地选择，如果存在多个亲水基团，则从-(O- - )m-OX中选择，其中X是CH3或H，"m"是从6到25的整数；从核心延伸的亲水基团的数量为一个到核心中的环结构数量。本发明还涉及包含所述化合物的组合物和包含所述化合物残基的纳米结构，以及使用这种纳米结构。此外，该发明涉及获得所述化合物和纳米结构的方法。
• Synthesis of Nanosized “Cored” Star Polymers
  作者：James B. Beil、Steven C. Zimmerman

  DOI：10.1021/ma034556t

  日期：2004.2.1

  initiator with 1-but-3-enyl-4-vinylbenzene and styrene at low conversion produced soluble eight-armed star block copolymers. Through the ring-closing metathesis (RCM) reaction, the alkene groups of the polymer were intramolecularly cross-linked. The ester groups linking the cross-linked polymer arms to the porphyrin core were hydrolyzed, producing a “cored” star polymer with a molecular weight of approximately

  报道了一种合成方法，用于制备纳米级“有芯”星形聚合物。一个5,10,15,20-四（4-羧基苯基）卟啉核被四个2,2,6,6-四甲基哌啶基-1-氧基（TEMPO）引发基团官能化。合成了苯乙烯和4-羟基苯乙烯的四臂星形共聚物，并用3,5-二（3-丁烯-1-氧基）苄基溴官能团进行了官能化，但溶解性较差。作为替代，将5,10,15,20-四（3'，5'-二羟基苯基）卟啉用能够引发原子转移自由基聚合（ATRP）的2-溴-2-甲基-丙酰基进行官能化。核引发剂与1-丁-3-烯基-4-乙烯基苯和苯乙烯的低转化率共聚产生可溶的八臂星形嵌段共聚物。通过闭环复分解（RCM）反应，聚合物的烯基分子内交联。
• CHEMICAL COMPOUNDS FOR COATING OF NANOSTRUCTURES
  申请人：Spago Nanomedical AB

  公开号：EP3348560A1

  公开（公告）日：2018-07-18

  The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core. The core has covalently attached thereto: at least two anchoring groups, each anchoring group comprising an activated silane group; and at least one hydrophilic group extending from the core, the hydrophilic group comprising one or more hydrophilic polymer residues with a molecular composition of (aO+bN)/(cC+dS+eSi+fP) > 0.3 where a, b, c, d, e and f are the mol percentage of oxygen (O), nitrogen (N), carbon (C), sulfur (S), silicon (Si) and phosphorus (P), respectively; and the number of hydrophilic groups extending from the core is from one to the number of ring structures in the core. The present invention also relates to compositions comprising the chemical compound and nanostructures comprising residues of the chemical compound as well as the use of such nanostructures. Furthermore, the invention relates to methods for obtaining the chemical compounds and the nanostructures.

  本申请涉及一种由芳香族核心或碳环、非芳香族核心组成的化合物。核心上共价连接有：至少两个锚定基团，每个锚定基团包括一个活化硅烷基团；以及至少一个从核心延伸出来的亲水基团，亲水基团包括一个或多个亲水聚合物残基，其分子组成为 (aO+bN)/(cC+dS+eSi+fP) > 0.3 其中，a、b、c、d、e 和 f 分别为氧 (O)、氮 (N)、碳 (C)、硫 (S)、硅 (Si) 和磷 (P) 的摩尔百分比；从核心延伸出的亲水基团的数目从 1 到核心中环结构的数目。本发明还涉及包含该化合物的组合物和包含该化合物残留物的纳米结构以及此类纳米结构的使用。此外，本发明还涉及获得化合物和纳米结构的方法。
• Chemical Compounds For Coating Of Nanostructures
  申请人：Spago Nanomedical AB

  公开号：US20190352459A1

  公开（公告）日：2019-11-21

  The present application relates to a chemical compound comprising an aromatic core, or a carbocyclic, non-aromatic, core, wherein the aromatic core is a benzene ring or a biphenyl; the carbocyclic, non-aromatic core is a 5 to 7 membered ring. The core has covalently attached thereto: at least two anchoring groups, each anchoring group comprising an activated silane group, wherein the anchoring groups have the following general formula -A-(CH 2 )nSiY3 wherein A is a covalent bond or O, “n” is an integer from 1 to 3, and Y is independently a methoxy group or an ethoxy group; and at least one hydrophilic group extending from the core, the hydrophilic group comprising one or more hydrophilic polymer residues with a molecular composition of (aO+bN)/(cC+dS+eSi+fP)>0.3 where a, b, c, d, e and f are the mol percentage of oxygen (O), nitrogen (N), carbon (C), sulfur (S), silicon (Si) and phosphorus (P), respectively; wherein the hydrophilic polymer residue(s) is(are) selected, independently of each other if more than one hydrophilic group is present, from —(O—CH 2 —CH 2 ) m —OX, wherein Xis CH 3 or H, and “m” is an integer from 6 to 25; and the number of hydrophilic groups extending from the core is from one to the number of ring structures in the core. The present invention also relates to compositions comprising the chemical compound and nanostructures comprising residues of the chemical compound as well as the use of such nanostructures. Furthermore, the invention relates to methods for obtaining the chemical compounds and the nanostructures.