L-phenylalanyl-glycine ethyl ester*HCl | 41041-68-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-phenylalanyl-glycine ethyl ester*HCl
• 英文别名: H-L-Phe-Gly-OEt*HCl；L-Phe-Gly-OEt*HCl；HCl*Phe-Gly-OEt；N-L-phenylalanyl-glycine ethyl ester; hydrochloride；N-L-Phenylalanyl-glycin-aethylester; Hydrochlorid；Ethyl L-phenylalanylglycinate hydrochloride；ethyl 2-[[(2S)-2-amino-3-phenylpropanoyl]amino]acetate;hydrochloride
• CAS: 41041-68-3
• 化学式: C₁₃H₁₈N₂O₃*ClH
• 分子量: 286.758
• InChiKey: CCDOZXJACASXAO-MERQFXBCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.66
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  81.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  L-phenylalanyl-glycine ethyl ester*HCl 在 sodium hydroxide 、 1-羟基苯并三唑 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 N-tert-butoxycarbonyl-L-phenylalanine-L-phenylalanine-glycine
  参考文献：
  名称：

  Lipkowski, Andrzej W.; Misicka, Aleksandra; Drabarek, Stefania, Polish Journal of Chemistry, 1981, vol. 55, # 4, p. 813 - 818

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl (N-tert-butoxycarbonyl-L-phenylalanyl)glycinate 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 反应 0.5h， 以88%的产率得到L-phenylalanyl-glycine ethyl ester*HCl
  参考文献：
  名称：

  Korshunova, G. A.; Petrova, M. G.; Taskaeva, Yu. M., Journal of general chemistry of the USSR, 1987, vol. 57, # 6, p. 1246 - 1252

  摘要：

  DOI：

文献信息

• Inhibition of Urease Activity by Dipeptidyl Hydroxamic Acids.
  作者：Shinjiro ODAKE、Kazuaki NAKAHASHI、Tadanori MORIKAWA、Sachiko TAKEBE、Kyoichi KOBASHI

  DOI：10.1248/cpb.40.2764

  日期：——

  dipeptidyl hydroxamic acids (H-X-Gly-NHOH: X = amino acid residues) was synthesized, and the inhibitory activity against Jack bean and Proteus mirabilis ureases [EC 3.5.1.5] was examined. A number of H-X-Gly-NHOH inhibited Jack bean urease with an I50 of the order of 10(-6) M and inhibited Proteus mirabilis urease with an I50 of the order of 10(-5) M. The inhibition against Jack bean urease was more potent

  合成了一系列二肽基异羟肟酸（HX-Gly-NHOH：X =氨基酸残基），并研究了其对杰克豆和奇异变形杆菌脲酶的抑制活性[EC 3.5.1.5]。许多HX-Gly-NHOH抑制Jack bean脲酶的I50为10（-6）M并抑制奇异变形杆菌尿素酶的I50约为10（-5）M。比使用相应的氨基酰基异羟肟酸（HX-NHOH）更有效。
• An Improvement of the Anderson Test by the Use of High Performance Liquid Chromatography
  作者：Toshifumi Miyazawa、Takashi Yamada、Shigeru Kuwata

  DOI：10.1246/bcsj.61.606

  日期：1988.2

  replacement of the N-benzyloxycarbonyl (Z) group in the Anderson peptide (Z–Gly–L/D–Phe–Gly–OEt) by Z–L-Ala and the subsequent separation of the diastereomers of the resulting tetrapeptide by reversed-phase HPLC offer a more convenient version with higher accuracy to the original Anderson test for studying racemization in peptide synthesis.

  用 Z-L-Ala 替换安德森肽 (Z-Gly-L/D-Phe-Gly-OEt) 中的 N-苄氧羰基 (Z) 基团，随后通过反向-相 HPLC 提供了一个更方便、精度更高的版本，用于研究肽合成中的外消旋化的原始 Anderson 测试。
• Thiopeptolide substrates for vertebrate collagenase
  申请人：Monsanto Company

  公开号：US04569907A1

  公开（公告）日：1986-02-11

  The disclosure relates to novel synthetic thiopeptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences: R-Pro-X-Gly-S-Y-Z-Gly-R.sub.1 wherein R=H or N-protecting group, X=Leu, Ile, Phe, Val, Gln, Ala, Y=Leu, Ile, Phe, Val, Ala, Z=Leu, Ile, Phe, Val, Gln, Ala, and R.sub.1 =terminal amide, carboxyl or ester group.

  本公开涉及具有高胶原酶酶活性的新型合成硫代肽酰亚胺底物。这些底物具有以下氨基酸序列：R-Pro-X-Gly-S-Y-Z-Gly-R.sub.1，其中R=H或N-保护基，X=Leu，Ile，Phe，Val，Gln，Ala，Y=Leu，Ile，Phe，Val，Ala，Z=Leu，Ile，Phe，Val，Gln，Ala，R.sub.1=末端酰胺，羧基或酯基。
• Novel thiopeptolide substrates for vertebrate collagenase
  申请人：Monsanto Company

  公开号：US04596675A1

  公开（公告）日：1986-06-24

  The disclosure relates to novel synthetic thiopeptolide substrates having high activity for the enzyme collagenase. These substrates have the following amino acid sequences: R-Pro-X-Gly-S-Y-Z-Gly-R.sub.1 wherein R=H or N-protecting group, X=Leu, Ile, Phe, Val, Gln, Ala, Y=Leu, Ile, Phe, Val, Ala, Z=Leu, Ile, Phe, Val, Gln, Ala, and R.sub.1 =terminal amide, carboxyl or ester group.

  本公开涉及具有对胶原酶酶具有高活性的新合成硫代肽内酯底物。这些底物具有以下氨基酸序列：R-Pro-X-Gly-S-Y-Z-Gly-R.sub.1，其中R = H或N-保护基，X = Leu，Ile，Phe，Val，Gln，Ala，Y = Leu，Ile，Phe，Val，Ala，Z = Leu，Ile，Phe，Val，Gln，Ala，R.sub.1 =末端酰胺，羧基或酯基。
• Synthesis and characterization by 13C-CP-MAS- and high resolution 1H-, 13C-NMR of new ureido sugars, derivatives of methyl 2-amino-2-deoxy-β-d-glucopyranose and dipeptides
  作者：Andrzej Temeriusz、Bogusława Piekarska-Bartoszewicz、Iwona Wawer

  DOI：10.1016/s0008-6215(97)00236-x

  日期：1997.11

  Dipeptide ethyl and benzyl esters were used as amination agents in reaction with methyl 3,4,6-tri-O-acetyl-2-deoxy-2-(4-nitrophenoxycarbonylamino)-beta-D-glucopyranoside(1). Ten new ureido sugars, derivatives of GlyAla, AlaGly, AlaAla, GlyVal, ValGly, LeuGly, PheGly, GlyPhe, and AlaPhe; were obtained. The new ureido sugars were studied by means of H-1- and C-13-NMR spectroscopy in solution, and C-13-CP-MAS-NMR in the solid-state. (C) 1997 Elsevier Science Ltd. All rights reserved.