[5-(1-苯基吲唑-3-基)呋喃-2-基]甲醇 | 377739-74-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: [5-(1-苯基吲唑-3-基)呋喃-2-基]甲醇
• 英文名称: [5-(1-phenyl-1H-indazol-3-yl)-furan-2-yl]methanol
• 英文别名: [5-(1-Phenylindazol-3-YL)furan-2-YL]methanol
• CAS: 377739-74-7
• 化学式: C₁₈H₁₄N₂O₂
• 分子量: 290.321
• InChiKey: NWEZIGFGYORHCZ-UHFFFAOYSA-N

物化性质

• 沸点：
  429.2±45.0 °C(Predicted)
• 密度：
  1.27±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-苯甲酰基呋喃-2-甲酸甲酯 在 lead(IV) acetate 、 calcium borohydride 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 7.0h， 生成 [5-(1-苯基吲唑-3-基)呋喃-2-基]甲醇
  参考文献：
  名称：

  1-Benzyl-3-(5‘-hydroxymethyl-2‘-furyl)indazole (YC-1) Derivatives as Novel Inhibitors Against Sodium Nitroprusside-Induced Apoptosis

  摘要：

  Antiapoptotic agents based on 1-benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (22, YC-1) derivatives were explored for effective treatment of sepsis and septic shock. We found that compound 22, 1-benzyl-3-(5'-methoxymethyl-2'-furyl)indazole (27), and 1-phenyl-3-(5'-hydroxymethyl-2'-furyl)-indazole (23) were the most effective inhibitors of sodium nitroprusside-induced vascular smooth muscle cell apoptosis. These three compounds are proposed as potential therapeutic agents for the treatment of sepsis.

  DOI：

  10.1021/jm020070b

文献信息

• Compounds, compositions and methods
  申请人：Park Jong-Wan

  公开号：US20050187276A1

  公开（公告）日：2005-08-25

  The present invention provides methods and pharmaceutical compositions for inhibiting expressions of HIF and HIF regulated genes, inhibiting angiogenesis, inducing cell cycle arrest in tumor cells, and treating cell proliferating diseases or conditions.

  本发明提供了一种抑制HIF和HIF调节基因表达、抑制血管生成、诱导肿瘤细胞细胞周期停滞和治疗细胞增殖性疾病或情况的方法和制药组合物。
• Synthesis of 1-Benzyl-3-(5‘-hydroxymethyl-2‘-furyl)indazole Analogues as Novel Antiplatelet Agents
  作者：Fang-Yu Lee、Jin-Cherng Lien、Li-Jiau Huang、Tsang-Miao Huang、Sheng-Chung Tsai、Che-Ming Teng、Chin-Chung Wu、Fong-Chi Cheng、Sheng-Chu Kuo

  DOI：10.1021/jm010001h

  日期：2001.10.1

  1-Benzyl-3-(5'-hydroxymethyl-2'-furyl)indazole (28, YC-1) was selected as the lead compound for systemic structural modification. After screening for antiplatelet activity, SARs of YC-1 analogues were established. Among these potent active derivatives, compounds 29, 30, 31, 44, and 45 functioned as potent activators of sGC and inhibitors of PDE5 with potency comparable to that of YC-1. In addition, compound 58 was found to be a selective and potent inhibitor of protease-activated receptor type 4 (PAR4)-dependent platelet activation.
• Method of treating sepsis
  申请人：Yung Shin Pharmaceutical Ind. Co., Ltd.

  公开号：EP1331223B1

  公开（公告）日：2008-02-13
• COMPOUNDS, COMPOSITIONS AND METHODS
  申请人：HIF BIO INC.

  公开号：EP1646382A2

  公开（公告）日：2006-04-19
• US7226941B2
  申请人：——

  公开号：US7226941B2

  公开（公告）日：2007-06-05