2-(2-硝基苯基)恶唑 | 62882-07-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 2-(2-硝基苯基)恶唑
• 英文名称: 2-(2-nitrophenyl)oxazole
• 英文别名: 2-(2-nitro-phenyl)-oxazole；2-(2-Nitro-phenyl)-oxazol；2-(o-Nitro-phenyl)-oxazol；2-(2-Nitrophenyl)-1,3-oxazole
• CAS: 62882-07-9
• 化学式: C₉H₆N₂O₃
• 分子量: 190.158
• InChiKey: JWLIPOOAITVBES-UHFFFAOYSA-N

物化性质

• 熔点：
  38-39 °C
• 沸点：
  347.1±44.0 °C(Predicted)
• 密度：
  1.333±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(2-硝基苯基)恶唑 在 吡啶 、 盐酸 、 乙醇 、 镍 作用下， 生成 sulfanilic acid-(2-oxazol-2-yl-anilide)
  参考文献：
  名称：

  2-Phenyloxazole and ortho-Substituted Derivatives

  摘要：

  DOI：

  10.1021/ja01256a013
• 作为产物：
  描述：

  N-(2,2-dimethoxyethyl)-2-nitrobenzamide 在 甲烷磺酸 、 phosphorus pentoxide 作用下， 反应 1.0h， 以24%的产率得到2-(2-硝基苯基)恶唑
  参考文献：
  名称：

  2-取代恶唑的制备

  摘要：

  摘要 描述了一种简单经济的 2-取代恶唑合成方法及其适用范围。

  DOI：

  10.1081/scc-120006015

文献信息

• [EN] BENZOCARBONYL COMPOUNDS<br/>[FR] COMPOSÉS BENZOCARBONYLE
  申请人：VIVACE THERAPEUTICS INC

  公开号：WO2019113236A1

  公开（公告）日：2019-06-13

  Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

  本文提供了包含所述化合物的药物组合物，用于治疗癌症。具体的癌症包括那些由YAP/TAZ介导或由YAP/TAZ与TEAD相互作用调节的癌症。
• Herbicidal sulfonamides
  申请人：E. I. Du Pont de Nemours and Company

  公开号：US04465505A1

  公开（公告）日：1984-08-14

  This invention relates to ortho-heterocyclic benzene sulfonylureas which are useful as herbicides and growth regulants.

  这项发明涉及对硫酰脲基的正异杂环苯基甲酰脲，可用作除草剂和生长调节剂。
• 2-Substituted 5-oxazolyl indole compounds useful as IMPDH inhibitors and pharmaceutical compositions comprising same
  申请人：——

  公开号：US20030232866A1

  公开（公告）日：2003-12-18

  Compounds having the formula (I), 1 are effective as inhibitors of IMPDH enzyme, wherein R 3 is alkyl, substituted alkyl, alkoxy, haloalkoxy, or halogen, preferably methoxy, ethoxy, or trifluoromethoxy; and R 1 , R 2 , R 4 , and R 5 are as defined in the specification.

  具有化学式(I)的化合物作为IMPDH酶的抑制剂具有很好的效果，其中R3是烷基，取代烷基，烷氧基，卤代烷氧基或卤素，优选是甲氧基，乙氧基或三氟甲氧基；而R1、R2、R4和R5如规范中定义。
• [EN] IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS<br/>[FR] DERIVES D'IMIDAZOLINE UTILISES COMME LIGANDS DU RECEPTEUR ADRENERGIQUE ALPHA-1A
  申请人：GLAXO GROUP LTD

  公开号：WO2000066563A1

  公开（公告）日：2000-11-09

  Compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof are disclosed. Formula (i) wherein R?2, R3, R4 and R5¿ are independently H, halogen, -OH, -C¿1-3?alkyl, -C1-3alkoxy, -SC1-2alkyl, or -CF3, with the proviso that at least 2 of R?2, R3, R4 and R5¿ are H; R6 is H or -CH¿3; R?1 is -S(O)¿nR?7 where n is 1 or 2, -S(O)¿2NHR?8, -C(O)R?9, -NR14R15, -C(R17)=NOR16¿, (a) or a 5,6, or 7 membered heteroalkyl or heteroaryl group optionally substituted. Such compounds are useful in the treatment of Alpha-1A mediated diseases or conditions such as urinary incontinence.

  公开了式(I)的化合物或其药学上可接受的盐或溶剂化物。式(I)中，R?2、R3、R4和R5¿独立地为H、卤素、-OH、-C¿1-3?烷基、-C1-3烷氧基、-SC1-2烷基或-CF3，但至少有2个R?2、R3、R4和R5¿为H；R6为H或-CH¿3；R?1为-S(O)¿nR?7，其中n为1或2，-S(O)¿2NHR?8，-C(O)R?9，-NR14R15，-C(R17)=NOR16¿，(a)或可选择取代的5、6或7成员杂烷基或杂芳基基团。这些化合物在治疗α-1A介导的疾病或病况，例如尿失禁方面有用。
• Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests
  申请人：——

  公开号：US20040242645A1

  公开（公告）日：2004-12-02

  This invention pertains to compounds of Formula I, their N-oxides and suitable salts (Formula I) wherein A is O or S; G is a 5- or 6-membered heteroaromatic ring or a 5- or 6-membered nonaromatic heterocyclic ring optionally including one or two ring members selected from the group consisting of C(═O), SO or S(O) 2 , each ring optionally substituted with from one to four R 2 ; each J is independently a phenyl ring, a 5- or 6-membered heteroaromatic ring or an aromatic 8-, 9- or 10-membered fused carbobicyclic or heterobicyclic ring system, wherein each ring or ring system is optionally substituted with from one to four R 3 ; and R 1 , R 2 , R 3 , R 4 and n are as defined in the disclosure. Also disclosed are methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt of the compound (e.g., as a composition described herein). This invention also pertains to a composition for controlling an invertebrate pest comprising a biologically effective amount of a compound of Formula I, an N-oxide thereof or a suitable salt of the compound and at least one additional component selected from the group consisting of surfactants, solid diluents and liquid diluents. 1

  本发明涉及式I的化合物，其N-氧化物和适宜的盐（式I）其中A是O或S; G是5-或6-成员杂芳环或5-或6-成员非芳杂环，可选地包括一个或两个环成员，所选自C（═O），SO或S（O）2的群，每个环可选地取代1-4个R2; 每个J是独立的苯环，5-或6-成员杂芳环或芳香8-、9-或10-成员融合碳杂双环系统，其中每个环或环系统可选地取代1-4个R3; R1、R2、R3、R4和n如本公开说明中所定义。本发明还公开了一种控制无脊椎动物害虫的方法，包括将无脊椎动物害虫或其环境与式I的化合物，其N-氧化物或化合物的适宜盐的生物有效量接触（例如，作为本文所述的组合物）。本发明还涉及一种用于控制无脊椎动物害虫的组合物，其包括式I的化合物、其N-氧化物或化合物的适宜盐的生物有效量和至少一种来自表面活性剂、固体稀释剂和液体稀释剂的群体中选择的其他成分。