[[(Z)-1-丙烯基]磺酰基]苯 | 40410-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: [[(Z)-1-丙烯基]磺酰基]苯
• 英文名称: phenyl ((Z)-prop-1-en-1-yl) sulfone
• 英文别名: cis-1-(phenylsulfonyl)-1-propene；cis-phenylsulfonyl-1-propene；Z-1-phenylsulfonyl propene；phenyl-(cis-propenyl)-sulfone；Phenyl-(cis-propenyl)-sulfon；(Z)-Phenyl-1-propenylsulfon；Benzene, (1-propenylsulfonyl)-, (Z)-；[(Z)-prop-1-enyl]sulfonylbenzene
• CAS: 40410-87-5
• 化学式: C₉H₁₀O₂S
• 分子量: 182.243
• InChiKey: BWSNBXGFQGTUOK-WAPJZHGLSA-N

物化性质

• 熔点：
  66-67 °C
• 沸点：
  176-180 °C(Press: 35 Torr)
• 密度：
  1.154±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [[(Z)-1-丙烯基]磺酰基]苯 在 potassium tert-butylate 作用下， 以 叔丁醇 为溶剂， 生成 (E)-1-propenyl phenyl sulfone
  参考文献：
  名称：

  Kimmelma, Reijo, Acta Chemica Scandinavica, 1993, vol. 47, # 12, p. 1201 - 1206

  摘要：

  DOI：
• 作为产物：
  描述：

  烯丙基苯砜 在 正丁基锂 、 三氟甲磺酸 作用下， 以 甲苯 为溶剂， 反应 12.17h， 生成 [[(Z)-1-丙烯基]磺酰基]苯
  参考文献：
  名称：

  通过烯丙基硅烷的去甲硅烷基化立体选择性地制备乙烯基砜

  摘要：

  烯丙基砜可以通过烯丙基硅烷中间体共轭以提供乙烯基砜。在原去甲硅烷基化步骤中观察到的立体选择性为立体选择性制备（E）-二和三取代的乙烯基砜提供了一种新方法。

  DOI：

  10.1016/s0040-4039(00)60467-7

文献信息

• Characterising polypeptides
  申请人：Hamon Christian

  公开号：US20050042676A1

  公开（公告）日：2005-02-24

  Provided is a method for characterising a polypeptide or a population of polypeptides, which method comprises the steps of: (a) contacting a sample comprising one or more polypeptides with a lysine reactive agent to cap ε-amino groups; (b) optionally reacting the sample of polypeptides with an amine reactive reagent to block α-amino groups; (c) digesting the sample of polypeptides with a cleavage reagent to produce peptide fragments; (d) optionally deactivating the cleavage reagent; (e) removing those peptides having uncapped or unblocked amino groups; and (f) recovering the N-terminal peptides.

  提供了一种表征多肽或多肽群体的方法，该方法包括以下步骤：（a）将包含一个或多个多肽的样品与赖氨酸反应性试剂接触以盖住ε-氨基团；（b）可选择性地将多肽样品与胺反应性试剂反应以阻断α-氨基团；（c）用裂解试剂消化多肽样品以产生肽片段；（d）可选择性地去活化裂解试剂；（e）去除那些具有未盖住或未阻断氨基团的肽；（f）回收N-末端肽。
• TETRAHYDRO- AND DIHYDROQUINAZOLINONES
  申请人：Finsinger Dirk

  公开号：US20090318444A1

  公开（公告）日：2009-12-24

  The present invention relates to the use of tetrahydro- and dihydroquinazolinones of formula I as protein kinase activators or inhibitors, a method for their manufacture, their use for the preparation of a medicament for the treatment of diseases, their use for the manufacture of a pharmaceutical composition and new tetrahydro- and dihydroquinazolinones.

  本发明涉及使用式I的四氢-和二氢-喹唑酮作为蛋白激酶的激活剂或抑制剂，一种制备它们的方法，它们用于制备治疗疾病的药物，用于制备制药组合物和新的四氢-和二氢-喹唑酮。
• Photoredox-Catalyzed Radical–Radical Cross-Coupling of Sulfonyl Chlorides with Trifluoroborate Salts
  作者：Sheng-Ping Liu、Yan-Hong He、Zhi Guan

  DOI：10.1021/acs.joc.3c01124

  日期：2023.8.4

  synthesis of sulfone compounds with diverse structures by visible-light-catalyzed radical–radical cross-coupling of sulfonyl chlorides and trifluoroborate salts. Allyl, benzyl, vinyl, and aryl trifluoroborates can be successfully cross-coupled with (hetero)aryl and alkyl sulfonyl chlorides, respectively. This strategy features redox neutrality, good substrate generality, simple operation, and benign reaction

  砜广泛存在于天然产物和药物分子中。在这里，我们公开了一种通过磺酰氯和三氟硼酸盐的可见光催化自由基-自由基交叉偶联直接合成具有不同结构的砜化合物的策略。烯丙基、苄基、乙烯基和芳基三氟硼酸酯可以分别与（杂）芳基和烷基磺酰氯成功交叉偶联。该策略具有氧化还原中性、底物通用性好、操作简单、反应条件良好等特点。
• Method for characterising polypeptides
  申请人：Xzillion GmbH & CO.KG

  公开号：EP1267170A1

  公开（公告）日：2002-12-18

  Provided is a method for characterising a polypeptide or a population of polypeptides, which method comprises the steps of: (a) contacting a sample comprising one or more polypeptides with a lysine reactive agent to cap ε-amino groups; (b) optionally reacting the sample of polypeptides with an amine reactive reagent to block α-amino groups; (c) digesting the sample of polypeptides with a sequence specific cleavage reagent to produce peptide fragments; (d) optionally deactivating the cleavage reagent; (e) removing those peptides having uncapped or unblocked amino groups; and (f) recovering the N-terminal peptides.

  提供了一种表征多肽或多肽群的方法，该方法包括以下步骤 (a) 将包含一种或多种多肽的样品与赖氨酸反应剂接触，以封盖ε-氨基； (b) 选择性地将多肽样品与胺反应试剂反应，以阻断α-氨基基团； (c) 用序列特异性裂解试剂消化多肽样品，产生肽片段； (d) 选择性地使裂解试剂失活； (e) 去除具有未封端或未阻断氨基的多肽；以及 (f) 回收 N 端肽。
• An Isomünchnone-Based Method for the Synthesis of Highly Substituted 2(1<i>H</i>)-Pyridones
  作者：Albert Padwa、Scott M. Sheehan、Christopher S. Straub

  DOI：10.1021/jo9911600

  日期：1999.11.1

  1-(Benzenesulfonyl-diazoacetyl)-pyrrolidin-2-one was prepared by a diazo transfer of 1-(benzenesulfonylacetyl)-pyrrolidin-2-one with p-acetamidobenzenesulfonyl azide and triethylamine. Treatment; of the diazoimide with a catalytic quantity of rhodium(II) acetate resulted in the formation of an isomunchnone dipole, which underwent bimolecular trapping with various dipolarophiles in high yield. The initially formed cycloadducts were not isolable or observed, as they all readily underwent ring opening to give the 3-hydroxy-2(1H)-pyridone ring system. The 3-hydroxy-2(1H)-pyridones were readily converted to the corresponding triflates, which function as suitable substrates in various types of palladium-catalyzed cross-coupling reactions. Commercial tetrakis(triphenylphoshine)palladium was found to be a particularly effective catalyst for the cross-coupling with aryl, vinyl, and acetylenic partners. An application of the method to the synthesis of the indolizidine alkaloid (+/-)-ipalbidine was carried out in eight steps in 17% overall yield. The angiotensin-converting enzyme inhibitor (-)-A58365A was also synthesized by a process based on the [3 + 2]-cycloaddition reaction of a phenylsulfonyl substituted isomunchnone intermediate. The starting material for this process was prepared from L-pyroglutamic acid and involved using a diazo phenylsulfonyl substituted pyrrolidine imide. Treatment of the diazoimide with Rh-2(OAc)(4) in the presence of methyl vinyl ketone afforded a 3-hydroxy-2-pyridone derivative, which was subsequently converted to the ACE inhibitor in six additional steps.