1-propargyloxybenzene-3,5-dimethanol | 859857-54-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-propargyloxybenzene-3,5-dimethanol
• 英文别名: 3,5-Bis(hydroxymethyl)-1-propargyloxybenzene；[3-(hydroxymethyl)-5-prop-2-ynoxyphenyl]methanol
• CAS: 859857-54-8
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: AVALJSLMPCGSJR-UHFFFAOYSA-N

物化性质

• 沸点：
  389.8±42.0 °C(Predicted)
• 密度：
  1.217±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-propargyloxybenzene-3,5-dimethanol 在 吡啶 、 氯化亚砜 、 copper(ll) sulfate pentahydrate 、 L-ascorbic acid sodium salt 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 24.0h， 生成 1-[[3,5-Bis[[4-[[3,5-bis(chloromethyl)phenoxy]methyl]triazol-1-yl]methyl]phenyl]methyl]-4-[[3,5-bis(chloromethyl)phenoxy]methyl]triazole
  参考文献：
  名称：

  Synthesis, photophysical and electrochemical properties of 1,2,3-triazolyl bridged ferrocenyl dendrimers through click chemistry

  摘要：

  基于三唑的新型树状聚合物通过点击化学实现，采用了发散和汇聚两种方法。树状聚合物1-4中更多的铁芴基和三唑基团的存在改变了伏安图中的电流电位曲线，以及紫外-可见光谱中的吸收系数。

  DOI：

  10.1039/c3nj00847a
• 作为产物：
  描述：

  5-羟基间苯二甲酸二甲酯 在 lithium aluminium tetrahydride 、 18-冠醚-6 、 potassium carbonate 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 18.0h， 生成 1-propargyloxybenzene-3,5-dimethanol
  参考文献：
  名称：

  Dendrimers Clicked Together Divergently

  摘要：

  Dendrimers containing 1,4-triazole linkages between each generation were grown divergently via the Click chemistry inspired Huisgen 1,3-dipolar cycloaddition reaction in the presence of a Cu(I) catalyst. The monomeric unit (1-propargylbenzene-3,5-dimethanol) contained the alkyne functionality, while the core (1,2-bis(2-azidoethoxy)ethane) and growing dendrimers presented the azide groups necessary for this type of Click reaction. The first generation dendrimer was also functionalized with alkyne termini to demonstrate an alternative pathway allowed by this chemistry. Synthesis and characterization, with infrared (IR), H-1 and C-13 NMR spectroscopies, high-resolution mass spectrometry, gel permeation chromatography (GPC), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA), are reported for these divergently grown dendrimers.

  DOI：

  10.1021/ma050302r

文献信息

• Synthesis and anticancer activity of bile acid dendrimers with triazole as bridging unit through click chemistry
  作者：Devaraj Anandkumar、Perumal Rajakumar

  DOI：10.1016/j.steroids.2017.06.007

  日期：2017.9

  Triazole-based novel dendrimers with bile acid surface groups have been synthesized through click chemistry by divergent approach and characterized by spectral data. All the dendrimers exhibit excellent anticancer activity. Higher-generation dendrimers exhibit better anticancer activity than the lower-generation dendrimers.

  具有胆汁酸表面基团的基于三唑的新型树枝状聚合物已通过点击化学通过发散方法合成，并通过光谱数据进行表征。所有树枝状聚合物都表现出优异的抗癌活性。与低代树枝状大分子相比，高代树枝状大分子表现出更好的抗癌活性。
• Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines
  作者：Waleed M. Hussein、Tzu-Yu Liu、Pirashanthini Maruthayanar、Saori Mukaida、Peter M. Moyle、James W. Wells、Istvan Toth、Mariusz Skwarczynski

  DOI：10.1039/c5sc03859f

  日期：——

  Conjugation of multiple peptides by their N-termini is a promising technique to produce branched multiantigenic vaccines.

  通过它们的N-末端连接多肽的共轭是生产分枝多抗原疫苗的一种有前途的技术。
• Effective Click Construction of <i>Bridged</i>- and <i>Spiro</i>-Multicyclic Polymer Topologies with Tailored Cyclic Prepolymers (<i>kyklo</i>-Telechelics)
  作者：Naoto Sugai、Hiroyuki Heguri、Kengo Ohta、Qingyuan Meng、Takuya Yamamoto、Yasuyuki Tezuka

  DOI：10.1021/ja103402c

  日期：2010.10.27

  topologies. A series of single cyclic poly(tetrahydrofuran), poly(THF), precursors having an alkyne group (Ia), an azide group (Ib), two alkyne groups at the opposite positions (Ic), and an alkyne group and an azide group at the opposite positions (Id) have been prepared by the ESA-CF process. Moreover, a bicyclic 8-shaped precursor having two alkyne groups at the opposite positions (Ie) was synthesized. The

  炔烃-叠氮化物加成，即点击反应与静电自组装和共价固定 (ESA-CF) 过程相结合，已被证明可有效构建各种前所未有的多环聚合物拓扑结构。一系列单环聚（四氢呋喃）、聚（THF）、具有炔基（Ia）、叠氮基（Ib）、相反位置的两个炔基（Ic）以及炔基和叠氮基的前体在相反的位置 (Id) 已由 ESA-CF 过程制备。此外，合成了在相反位置 (Ie) 具有两个炔基的双环 8 形前体。Ia 与具有叠氮化物基团的线性 (IIa) 和三臂星形 (IIb) 遥爪前驱体的后续点击反应已用于构建桥接型二元 (IIIa) 和三元 (IIIb) 桨状聚合物拓扑结构， 分别。同样，螺型串联三环 (IVa) 和四环 (IVb) 拓扑分别由 Ib/Ic 和 Ib/Ie 产生。此外，分别从Id、Ic/IIa和Ic/IIb合成了由重复环(Va)、交替环/线形(Vb)和交替环/星(Vc)单元组成的三种多环拓扑结构。 .
• DENDRITIC MOLECULES
  申请人：Monteiro Michael John

  公开号：US20120059173A1

  公开（公告）日：2012-03-08

  The invention relates to novel dendritic molecules and methods of making them. The dendritic molecules comprise arms, each of which arms is a polymer. The dendritic molecules can be synthesised by way of a reasonably small number of versatile and reliable step-wise reactions, especially click chemistry reactions. Chemical and structural heterogeneity is possible in the dendritic molecule. The invention also provides for surface and interior functionalisation of the molecule.

  该发明涉及新型树状分子及其制备方法。这些树状分子包括臂，每个臂都是一种聚合物。这些树状分子可以通过相对少量的多功能和可靠的逐步反应合成，特别是点击化学反应。树状分子中可能存在化学和结构上的异质性。该发明还提供了对分子的表面和内部功能化。
• VISCOSIFIED TREATMENT FLUIDS COMPRISING POLYOL DERIVATIZED CELLULOSE AND METHODS RELATING THERETO
  申请人：HALLIBURTON ENERGY SERVICES, INC.

  公开号：US20160257877A1

  公开（公告）日：2016-09-08

  Viscosified treatment fluids that include polyol derivatized cellulose may be useful in subterranean operations. For example, a method may include introducing a viscosified treatment fluid into a wellbore penetrating a subterranean formation, wherein the viscosified treatment fluid comprises an aqueous base fluid, borate ions, and a polyol derivatized cellulose, and wherein the polyol derivatized cellulose comprise a cellulosic backbone derivatized with pendants comprising (1) a terminal polyol and (2) at least one of an internal 1,2,3-triazole, an internal ester, and an internal amide.