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6-bromo-2-(4-bromophenyl)-3,4-dihydro-2H-chromene | 80151-04-8

中文名称
——
中文别名
——
英文名称
6-bromo-2-(4-bromophenyl)-3,4-dihydro-2H-chromene
英文别名
——
6-bromo-2-(4-bromophenyl)-3,4-dihydro-2H-chromene化学式
CAS
80151-04-8
化学式
C15H12Br2O
mdl
——
分子量
368.068
InChiKey
QJMINUCGXYAATL-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    429.5±45.0 °C(Predicted)
  • 密度:
    1.644±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    5.2
  • 重原子数:
    18
  • 可旋转键数:
    1
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.2
  • 拓扑面积:
    9.2
  • 氢给体数:
    0
  • 氢受体数:
    1

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    6-bromo-2-(4-bromophenyl)-3,4-dihydro-2H-chromene盐酸 作用下, 以 乙醇N,N-二甲基甲酰胺 为溶剂, 反应 216.0h, 生成 2-(4-Carbamimidoyl-phenyl)-chroman-6-carboxamidine; hydrochloride
    参考文献:
    名称:
    Synthesis and antirhinovirus activity of cyano and amidino substituted flavanoids
    摘要:
    Cyano and amidino flavans, isoflavans and 3(2H)-isoflavenes were synthesized in order to study their in vitro antirhinovirus activity, by comparison with the known corresponding chloro derivatives. The activity of the new compounds was evaluated on rhinovirus 1 B infected HeLa cell cultures by examining their ability to interfere with viral cytopathic effect and with plaque formation. It was found that generally the cyano derivatives behave like the chloro compounds, whereas the amidino derivatives show a lower activity, although always dependent on the position of substituent.
    DOI:
    10.1016/0223-5234(90)90191-5
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文献信息

  • US4461907A
    申请人:——
    公开号:US4461907A
    公开(公告)日:1984-07-24
  • Synthesis and antirhinovirus activity of cyano and amidino substituted flavanoids
    作者:C Conti、N Desideri、N Orsi、I Sestili、ML Stein
    DOI:10.1016/0223-5234(90)90191-5
    日期:1990.11
    Cyano and amidino flavans, isoflavans and 3(2H)-isoflavenes were synthesized in order to study their in vitro antirhinovirus activity, by comparison with the known corresponding chloro derivatives. The activity of the new compounds was evaluated on rhinovirus 1 B infected HeLa cell cultures by examining their ability to interfere with viral cytopathic effect and with plaque formation. It was found that generally the cyano derivatives behave like the chloro compounds, whereas the amidino derivatives show a lower activity, although always dependent on the position of substituent.
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