(Z,4S)-4-[tert-butyl(dimethyl)silyl]oxy-7-[(1R,2R,3S,5S)-5-[tert-butyl(dimethyl)silyl]oxy-2-[(Z)-oct-2-enyl]-3-(phenylmethoxymethoxy)cyclopentyl]hept-5-enoic acid | 1026248-50-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Z,4S)-4-[tert-butyl(dimethyl)silyl]oxy-7-[(1R,2R,3S,5S)-5-[tert-butyl(dimethyl)silyl]oxy-2-[(Z)-oct-2-enyl]-3-(phenylmethoxymethoxy)cyclopentyl]hept-5-enoic acid
• CAS: 1026248-50-9
• 化学式: C₄₀H₇₀O₆Si₂
• 分子量: 703.163
• InChiKey: XUPDHTBCMFVMJT-ADMWVQFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  11.3
• 重原子数：
  48
• 可旋转键数：
  23
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (Z,4S)-4-[tert-butyl(dimethyl)silyl]oxy-7-[(1R,2R,3S,5S)-5-[tert-butyl(dimethyl)silyl]oxy-2-[(Z)-oct-2-enyl]-3-(phenylmethoxymethoxy)cyclopentyl]hept-5-enoic acid 在 氢氟酸 作用下， 以 乙腈 为溶剂， 以87%的产率得到
  参考文献：
  名称：

  New marine prostanoids, preclavulone lactones, from the Okinawan soft coral Clavularia viridis

  摘要：

  Two new marine prostanoids, preclavulone lactones I (1) and II (2) were isolated from the Okinawan soft coral, Clavularia viridis. Their structures were determined based on spectroscopic analysis and chemical synthesis from (S)-malic acid. Preclavulone Lactones with side chains having absolute configurations opposite to those of mammalian prostanoids could be recognized as key intermediates in biosynthesis of clavulones. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10211-8
• 作为产物：
  描述：

  (±)-6-(4-methoxybenzyloxy)hex-1-yn-3-ol 在 Pd-BaSO₄ 咪唑 、 chromium(VI) oxide 、 正丁基锂 、 B-isopinocampheyl-9-borabicyclo[3.3.1]nonane 、 硫酸 、 氢气 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 六甲基磷酰三胺 为溶剂， 生成 (Z,4S)-4-[tert-butyl(dimethyl)silyl]oxy-7-[(1R,2R,3S,5S)-5-[tert-butyl(dimethyl)silyl]oxy-2-[(Z)-oct-2-enyl]-3-(phenylmethoxymethoxy)cyclopentyl]hept-5-enoic acid
  参考文献：
  名称：

  New marine prostanoids, preclavulone lactones, from the Okinawan soft coral Clavularia viridis

  摘要：

  Two new marine prostanoids, preclavulone lactones I (1) and II (2) were isolated from the Okinawan soft coral, Clavularia viridis. Their structures were determined based on spectroscopic analysis and chemical synthesis from (S)-malic acid. Preclavulone Lactones with side chains having absolute configurations opposite to those of mammalian prostanoids could be recognized as key intermediates in biosynthesis of clavulones. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)10211-8

文献信息

• New marine prostanoids, preclavulone lactones, from the Okinawan soft coral Clavularia viridis
  作者：Makoto Iwashima、Kinzo Watanabe、Kazuo Iguchi

  DOI：10.1016/s0040-4039(97)10211-8

  日期：1997.12

  Two new marine prostanoids, preclavulone lactones I (1) and II (2) were isolated from the Okinawan soft coral, Clavularia viridis. Their structures were determined based on spectroscopic analysis and chemical synthesis from (S)-malic acid. Preclavulone Lactones with side chains having absolute configurations opposite to those of mammalian prostanoids could be recognized as key intermediates in biosynthesis of clavulones. (C) 1997 Elsevier Science Ltd.