5-fluoro-2-[1-(6-p-tolyloxy-pyrimidin-4yl)-piperidin-4yloxy]-pyrimidin-4-ylamine | 1033833-56-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-fluoro-2-[1-(6-p-tolyloxy-pyrimidin-4yl)-piperidin-4yloxy]-pyrimidin-4-ylamine
• 英文别名: 5-Fluoro-2-(1-(6-(p-tolyloxy)pyrimidin-4-yl)piperidin-4-yloxy)pyrimidin-4-amine；5-fluoro-2-[1-[6-(4-methylphenoxy)pyrimidin-4-yl]piperidin-4-yl]oxypyrimidin-4-amine
• CAS: 1033833-56-5
• 化学式: C₂₀H₂₁FN₆O₂
• 分子量: 396.424
• InChiKey: NCSBGQOLRVYHKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  99.3
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  对甲酚 、 2-[1-(6-Chloropyrimidin-4-yl)piperidin-4-yl]oxy-5-fluoropyrimidin-4-amine 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 生成 5-fluoro-2-[1-(6-p-tolyloxy-pyrimidin-4yl)-piperidin-4yloxy]-pyrimidin-4-ylamine
  参考文献：
  名称：

  5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase

  摘要：

  A series of potent piperidine-linked cytosine derivatives were prepared as inhibitors of deoxycytidine kinase (dCK). Compound 9h was discovered to be a potent inhibitor of dCK and shows a good combination of cellular potency and pharmacokinetic parameters. Compound 9h blocks the incorporation of radiolabeled cytosine into mouse T-cells in vitro, as well as in vivo in mice following a T-cell challenge. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2009.09.082