[[2-chloro-1-(2-furyl)ethenyl]oxy]tri-isopropylsilane | 556025-77-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: [[2-chloro-1-(2-furyl)ethenyl]oxy]tri-isopropylsilane
• 英文别名: 2-[1-tri-isopropylsilyloxy-2-chloro-vinyl]-furan；2-[1-Tri-isopropylsilyloxy-2-chloro-vinyl]-furan；[2-chloro-1-(furan-2-yl)ethenoxy]-tri(propan-2-yl)silane
• CAS: 556025-77-5
• 化学式: C₁₅H₂₅ClO₂Si
• 分子量: 300.901
• InChiKey: NVMQFSISSWWGPF-UHFFFAOYSA-N

物化性质

• 沸点：
  298.6±28.0 °C(Predicted)
• 密度：
  0.992±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.01
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  22.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [[2-chloro-1-(2-furyl)ethenyl]oxy]tri-isopropylsilane 在 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 、 (1R,2R)-(-)-N-(对甲基苯磺酰基)-1,2-二苯基乙二胺 甲酸 、 氢氟酸 、 potassium tert-butylate 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 3.5h， 生成 (5R)-3-methyl-5-(2-furyl)-2-oxazolidinone
  参考文献：
  名称：

  Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

  摘要：

  As part of medicinal chemistry efforts we found it necessary to develop general syntheses of highly enantiomerically enriched 1-aryl-2-chloroethanols and 1-aryl-2-methylaminoethanols. A survey of literature methods suggested that a truly general approach had not yet been reported, encouraging us to undertake the development of such a methodology. This study describes the design, development, and reduction to practice of a general synthesis of chiral 1-aryl-2-chloroethanols and the transformation of these entities to highly enantiomerically enriched 1-aryl-2-methylaminoethanols. Of particular importance were observations of the impact of solvent and the method of catalyst preparation on the yield and enantiomerical excess of chlorohydrins prepared via Noyori transfer hydrogenations of aryl-chloromethyl ketones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.017
• 作为产物：
  描述：

  [[1-(2-furyl)ethenyl]oxy]tri-isopropylsilane 在 N-氯代丁二酰亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 [[2-chloro-1-(2-furyl)ethenyl]oxy]tri-isopropylsilane
  参考文献：
  名称：

  Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

  摘要：

  As part of medicinal chemistry efforts we found it necessary to develop general syntheses of highly enantiomerically enriched 1-aryl-2-chloroethanols and 1-aryl-2-methylaminoethanols. A survey of literature methods suggested that a truly general approach had not yet been reported, encouraging us to undertake the development of such a methodology. This study describes the design, development, and reduction to practice of a general synthesis of chiral 1-aryl-2-chloroethanols and the transformation of these entities to highly enantiomerically enriched 1-aryl-2-methylaminoethanols. Of particular importance were observations of the impact of solvent and the method of catalyst preparation on the yield and enantiomerical excess of chlorohydrins prepared via Noyori transfer hydrogenations of aryl-chloromethyl ketones. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2006.07.017

文献信息

• Pyridoquinoxaline antivirals
  申请人：——

  公开号：US20030207877A1

  公开（公告）日：2003-11-06

  The present invention provides a compound of formula I 1 or a pharmaceutically acceptable salt thereof wherein R 1 , R 2 and R 3 are as defined in the specification. The compounds are useful for the treatment of viral infections.

  本发明提供了I1式化合物或其药学上可接受的盐，其中R1、R2和R3如规范中所定义。这些化合物对于治疗病毒感染有用。
• Process to produce enantiomerically enriched 1-aryl-and 1-heteroaryl-2-aminoethanols
  申请人：Pfizer, Inc.

  公开号：US20040236151A1

  公开（公告）日：2004-11-25

  The invention relates to a method of preparing enantiomerically enriched amino alcohols of Formula I 1 wherein the variable R1, R2, and R3 are defined herein.

  本发明涉及一种制备对映体富集的式I1的氨基醇的方法，其中变量R1、R2和R3在此处定义。