1-(2-Hydroxyphenyl)decane-1,3-dione | 158634-29-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-Hydroxyphenyl)decane-1,3-dione
• CAS: 158634-29-8
• 化学式: C₁₆H₂₂O₃
• 分子量: 262.349
• InChiKey: DOFJETKSHTUQPI-UHFFFAOYSA-N

物化性质

• 沸点：
  381.8±17.0 °C(predicted)
• 密度：
  1.055±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-Hydroxyphenyl)decane-1,3-dione 在 硫酸 作用下， 以 溶剂黄146 为溶剂， 反应 1.5h， 以83%的产率得到2-heptyl-4H-chromen-4-one
  参考文献：
  名称：

  Synthesis and Properties of a New Family of Chiral Mesogens Containing the 2,3-Dihydrobenzopyran Nucleus

  摘要：

  A new class of mesogens A with a central chiral core based on the 2,3-dihydrobenzopyran nucleus was synthesized both in the racemic and optically pure form, and the thermotropic properties were studied. The distortion from structural linearity due to the presence of the 2,3-dihydropyran ring does not inhibit the existence of mesophases, and Ch, S-A, and S-C phases were observed according to the substituents present. The conformational constrictions imposed by cyclization proved not to be very important in determining the compactness of the cholesteric helix.

  DOI：

  10.1021/jo00099a022
• 作为产物：
  描述：

  2'-羟基苯乙酮 在 吡啶 、 氢氧化钾 作用下， 以 吡啶 为溶剂， 反应 2.5h， 生成 1-(2-Hydroxyphenyl)decane-1,3-dione
  参考文献：
  名称：

  Synthesis and Properties of a New Family of Chiral Mesogens Containing the 2,3-Dihydrobenzopyran Nucleus

  摘要：

  A new class of mesogens A with a central chiral core based on the 2,3-dihydrobenzopyran nucleus was synthesized both in the racemic and optically pure form, and the thermotropic properties were studied. The distortion from structural linearity due to the presence of the 2,3-dihydropyran ring does not inhibit the existence of mesophases, and Ch, S-A, and S-C phases were observed according to the substituents present. The conformational constrictions imposed by cyclization proved not to be very important in determining the compactness of the cholesteric helix.

  DOI：

  10.1021/jo00099a022

文献信息

• Synthetic quinolone signal analogues inhibiting the virulence factor elastase of Pseudomonas aeruginosa
  作者：Dávid Szamosvári、Valentin F. Reichle、Monica Jureschi、Thomas Böttcher

  DOI：10.1039/c6cc06295d

  日期：——

  We describe the synthesis of analogs of the Pseudomonas quinolone signal and the discovery of a potent inhibitor of the important virulence factor elastase of the human pathogenPseudomonas aeruginosa.

  我们描述了假单胞菌喹诺酮信号的类似物的合成，以及发现了对人类病原体假单胞菌的重要毒力因子弹性蛋白酶的有效抑制剂。
• Synthesis and Properties of a New Family of Chiral Mesogens Containing the 2,3-Dihydrobenzopyran Nucleus
  作者：Bianca F. Bonini、Paolo Carboni、Giovanni Gottarelli、Stefano Masiero、Gian Piero Spada

  DOI：10.1021/jo00099a022

  日期：1994.10

  A new class of mesogens A with a central chiral core based on the 2,3-dihydrobenzopyran nucleus was synthesized both in the racemic and optically pure form, and the thermotropic properties were studied. The distortion from structural linearity due to the presence of the 2,3-dihydropyran ring does not inhibit the existence of mesophases, and Ch, S-A, and S-C phases were observed according to the substituents present. The conformational constrictions imposed by cyclization proved not to be very important in determining the compactness of the cholesteric helix.