6-(2,2-Dibromo-vinyl)-quinoline | 651025-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-(2,2-Dibromo-vinyl)-quinoline
• 英文别名: 6-(2,2-Dibromoethenyl)quinoline；6-(2,2-dibromoethenyl)quinoline
• CAS: 651025-10-4
• 化学式: C₁₁H₇Br₂N
• 分子量: 312.991
• InChiKey: ZNWROCKKQFPOFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  喹啉-6-甲醛 、 四溴化碳 在 三苯基膦 作用下， 以22%的产率得到6-(2,2-Dibromo-vinyl)-quinoline
  参考文献：
  名称：

  Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections

  摘要：

  We report the synthesis of substituted quinolines and their in vitro biological evaluation against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis and Chagas' disease. Furthermore, several quinolines have also been tested for their anti-retroviral activity in HIV-1 infected cells. The structure activity relationships of these new synthetic compounds are discussed and emphasis was placed on the treatment of leishmania/HIV co-infections. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.09.007

文献信息

• Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections
  作者：Mohammed A. Fakhfakh、Alain Fournet、Eric Prina、Jean-François Mouscadet、Xavier Franck、Reynald Hocquemiller、Bruno Figadère

  DOI：10.1016/j.bmc.2003.09.007

  日期：2003.11

  We report the synthesis of substituted quinolines and their in vitro biological evaluation against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis and Chagas' disease. Furthermore, several quinolines have also been tested for their anti-retroviral activity in HIV-1 infected cells. The structure activity relationships of these new synthetic compounds are discussed and emphasis was placed on the treatment of leishmania/HIV co-infections. (C) 2003 Elsevier Ltd. All rights reserved.