1-(Bromomethyl)-3,5-bis[(3,5-didodecoxyphenyl)methoxy]benzene | 698347-59-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(Bromomethyl)-3,5-bis[(3,5-didodecoxyphenyl)methoxy]benzene
• 英文别名: 1-(bromomethyl)-3,5-bis[(3,5-didodecoxyphenyl)methoxy]benzene
• CAS: 698347-59-0
• 化学式: C₆₉H₁₁₅BrO₆
• 分子量: 1120.57
• InChiKey: JVMABVMFHAIRSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  27.6
• 重原子数：
  76
• 可旋转键数：
  55
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(Bromomethyl)-3,5-bis[(3,5-didodecoxyphenyl)methoxy]benzene 、 3,5-二羟基苯甲酸甲酯 在 18-冠醚-6 、 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 26.0h， 以98%的产率得到methyl 3,5-bis((3,5-bis((3,5-bis(dodecyloxy)benzyl)oxy)benzyl)oxy)benzoate
  参考文献：
  名称：

  Effects of Polymer Architecture and Nanoenvironment in Acylation Reactions Employing Dendritic (Dialkylamino)pyridine Catalysts

  摘要：

  The role of architecture and nanoenvironment in the catalytic properties of dendritic polymers containing 4-(dialkylamino)pyridines was investigated in the context of acylation reactions employing sterically demanding tertiary alcohols as substrates. Frechet-type benzyl ether and aliphatic ester dendrimers were prepared in a convergent manner from a common trivalent core containing three DMAP groups while a linear polymer was dendronized with aliphatic esters using a divergent growth scheme. Catalysis experiments clearly indicate that nanoenvironment plays the dominant role in determining the activity of the polymer catalysts, with the polyester platform being superior to the benzyl ether. Polymer architecture played little or no role in affecting catalysis. With respect to molecular transport and catalysis, this represents the first comparative study of the effect of architecture and nanoenvironment using structurally similar dendritic materials.

  DOI：

  10.1021/ma050701m
• 作为产物：
  描述：

  3,5-二羟基苯甲酸甲酯 在 lithium aluminium tetrahydride 、 18-冠醚-6 、 四溴化碳 、 potassium carbonate 、 三苯基膦 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 44.0h， 生成 1-(Bromomethyl)-3,5-bis[(3,5-didodecoxyphenyl)methoxy]benzene
  参考文献：
  名称：

  Effects of Polymer Architecture and Nanoenvironment in Acylation Reactions Employing Dendritic (Dialkylamino)pyridine Catalysts

  摘要：

  The role of architecture and nanoenvironment in the catalytic properties of dendritic polymers containing 4-(dialkylamino)pyridines was investigated in the context of acylation reactions employing sterically demanding tertiary alcohols as substrates. Frechet-type benzyl ether and aliphatic ester dendrimers were prepared in a convergent manner from a common trivalent core containing three DMAP groups while a linear polymer was dendronized with aliphatic esters using a divergent growth scheme. Catalysis experiments clearly indicate that nanoenvironment plays the dominant role in determining the activity of the polymer catalysts, with the polyester platform being superior to the benzyl ether. Polymer architecture played little or no role in affecting catalysis. With respect to molecular transport and catalysis, this represents the first comparative study of the effect of architecture and nanoenvironment using structurally similar dendritic materials.

  DOI：

  10.1021/ma050701m

文献信息

• An “Attachment Through Coordination” Approach to Side Chain Dendritic Polymers
  作者：Aikaterini K. Andreopoulou、Joannis K. Kallitsis

  DOI：10.1002/ejoc.200500370

  日期：2005.10

  paper reports the synthesis of side chain dendritic polymers by a newly developed “attachment through coordination” methodology. Initially, aromatic/aliphatic polyethers bearing two uncomplexed terpyridine (tpy) groups per repeating unit are prepared, and dendritic fragments core-functionalized with tpy-RuIIICl3 moieties are afterwards attached onto these free tpy side groups. The two second-generation

  本文报告了通过新开发的“通过配位连接”方法合成侧链树枝状聚合物。最初，制备每个重复单元带有两个未络合的三联吡啶 (tpy) 基团的芳香族/脂肪族聚醚，然后将用 tpy-RuIIICl3 部分核心官能化的树枝状片段连接到这些游离的 tpy 侧基上。这里使用的两个第二代烷氧基修饰的侧枝提供了在最终聚合物体系中的溶解性和发展有序结构的潜力。三联吡啶和钌离子之间的选择性络合被证明是完全覆盖所有初始聚合物基团的有效工具。因此合成了每个重复单元带有两个（树枝状）tpy-RuII-tpy 侧基部分的完全取代的树枝状聚合物，正如他们的 1H NMR 表征所证明的那样。同时合成了已经带有侧（树枝状）tpy-RuII-tpy 部分的可聚合大分子单体二醇，从而通过“大分子单体”生长方法进行后续聚合。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany
• Dendronized Rigid−Flexible Macromolecular Architectures:  Syntheses, Structure, and Properties in Bulk
  作者：A. K. Andreopoulou、B. Carbonnier、J. K. Kallitsis、T. Pakula

  DOI：10.1021/ma035688p

  日期：2004.5.1

  comprised of main-chain polymeric backbones while the side dendrons occupy the space between the layers. Actually, two types of LC ordering for the extended backbones within the main-chain layers could be distinguished. In general, the exact polymeric structure, side-dendrons' generation and main-chain flexible spacers' length, greatly influence the final polymeric properties, such as phase transitions and

  侧链树枝状聚合物由规则分段的交替的刚性-柔性主链单元和侧枝楔形物组成，并使用各种实验方法对它们的整体状态进行了分析。在大多数情况下获得高分子量聚合物，从而能够形成自支撑膜。这些聚合物的热和机械特性，通过DSC和动态力学分析，已经揭示出高度有序的性质，这在SALS和POM实验中得到了进一步支持。另外，它们的转变温度似乎在很大程度上取决于主链柔性间隔基的长度，类似于奇偶效应。对于这些聚合物材料，归因于其WAXS图案中强烈且分辨良好的衍射，得出各向同性和宏观取向样品中组织特征的存在。通过对与定向长丝相对应的WAXS模式的定性分析，可以推测出层状结构的发展，该结构由主链聚合物主链组成，而侧面树突占据了层之间的空间。实际上，可以区分主链层内扩展主干的两种LC排序。通常，确切的聚合物结构，侧树枝的生成和主链柔性间隔基的长度会极大地影响最终的聚合物性能，例如相变和结构参数。通过对与定向长丝相对应的WAX
• Iron Complexes of Dendrimer-Appended Carboxylates for Activating Dioxygen and Oxidizing Hydrocarbons
  作者：Min Zhao、Brett Helms、Elena Slonkina、Simone Friedle、Dongwhan Lee、Jennifer DuBois、Britt Hedman、Keith O. Hodgson、Jean M. J. Fréchet、Stephen J. Lippard

  DOI：10.1021/ja076817a

  日期：2008.4.1

  [Fe2([G-3]COO)4(4-RPy)2] were prepared, where [G-3]COO- is a third-generation dendrimer-appended terphenyl carboxylate ligand and 4-RPy is a pyridine derivative. The dendrimer environment provides excellent protection for the diiron center, reducing its reactivity toward dioxygen by about 300-fold compared with analogous complexes of terphenyl carboxylate ([G-1]COO-) ligands. An FeIIFeIII intermediate was characterized

  金属酶的活性位点通常深埋在疏水性蛋白质鞘内，保护它们免受不良水解和聚合反应的影响，使其发挥正常功能。为了模拟细菌单加氧酶活性位点的疏水环境，制备了通式 [Fe2([G-3]COO)4(4-RPy)2] 的二铁 (II) 化合物，其中 [G-3 ]COO-是第三代树枝状大分子附加的三联苯羧酸配体，4-RPy是吡啶衍生物。树枝状聚合物环境为二铁中心提供了极好的保护，与三联苯羧酸酯 ([G-1]COO-) 配体的类似配合物相比，其对分子氧的反应性降低了约 300 倍。FeIIFeIII 中间体通过电子、电子顺磁共振、穆斯堡尔、[Fe2([G-3]COO)4(4-PPy)2]氧化后的 X 射线吸收光谱分析，其中 4-PPy 是 4-吡咯烷并吡啶。结果与超氧物种的形成一致。这种二铁化合物在双氧存在下可以氧化外部底物。
• Effects of Polymer Architecture and Nanoenvironment in Acylation Reactions Employing Dendritic (Dialkylamino)pyridine Catalysts
  作者：Brett Helms、Catherine O. Liang、Craig J. Hawker、Jean M. J. Fréchet

  DOI：10.1021/ma050701m

  日期：2005.6.1

  The role of architecture and nanoenvironment in the catalytic properties of dendritic polymers containing 4-(dialkylamino)pyridines was investigated in the context of acylation reactions employing sterically demanding tertiary alcohols as substrates. Frechet-type benzyl ether and aliphatic ester dendrimers were prepared in a convergent manner from a common trivalent core containing three DMAP groups while a linear polymer was dendronized with aliphatic esters using a divergent growth scheme. Catalysis experiments clearly indicate that nanoenvironment plays the dominant role in determining the activity of the polymer catalysts, with the polyester platform being superior to the benzyl ether. Polymer architecture played little or no role in affecting catalysis. With respect to molecular transport and catalysis, this represents the first comparative study of the effect of architecture and nanoenvironment using structurally similar dendritic materials.