4-氨基-3,5-二甲基苯甲胺 | 917388-67-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-氨基-3,5-二甲基苯甲胺
• 中文别名: 4-氨基-3,5-二甲基苄基胺
• 英文名称: 4-amino-3,5-dimethylbenzylamine
• 英文别名: 4-(Aminomethyl)-2,6-dimethylaniline
• CAS: 917388-67-1
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: DDWHVGXUKKJOMM-UHFFFAOYSA-N

物化性质

• 沸点：
  283.4±35.0 °C(Predicted)
• 密度：
  1.041±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-氨基-3,5-二甲基苯甲胺 在 溶剂黄146 、 三乙胺 作用下， 以 甲醇 、 水 为溶剂， 反应 16.0h， 生成 di-tert-butyl {ethane-1,2-diylidenebis[nitrilo(3,5-dimethyl-4,1-phenylene)methylene]}biscarbamate
  参考文献：
  名称：

  A simple and practical preparation of an efficient water soluble olefin metathesis catalyst

  摘要：

  一种简便的克制量制备方法，用于制备一种双铵功能化的Ru-烷基亚烯配合物，该配合物有效地催化水中的环闭合重排和交叉重排反应。

  DOI：

  10.1039/c5gc00252d
• 作为产物：
  描述：

  4-氨基-3,5-二甲基苯氰 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 4-氨基-3,5-二甲基苯甲胺
  参考文献：
  名称：

  A simple and practical preparation of an efficient water soluble olefin metathesis catalyst

  摘要：

  一种简便的克制量制备方法，用于制备一种双铵功能化的Ru-烷基亚烯配合物，该配合物有效地催化水中的环闭合重排和交叉重排反应。

  DOI：

  10.1039/c5gc00252d

文献信息

• Aminoacetamide acyl guanidines as beta-secretase inhibitors
  申请人：Gerritz Samuel

  公开号：US20060287287A1

  公开（公告）日：2006-12-21

  There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 2 , R 3 , R 4 , R 5 , R 25 , R 26 and R 27 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

  提供了一系列的取代酰基胍类化合物，符合以下化学式（Ik）或其立体异构体；或其药学上可接受的盐，其中R2、R3、R4、R5、R25、R26和R27如本文所定义，它们的药物组合物和使用方法。这些化合物抑制β-分泌酶对淀粉样前体蛋白（APP）的加工，更具体地说，抑制Aβ肽的产生。本公开涉及对β-淀粉样蛋白产生相关的神经疾病的治疗有用的化合物，如阿尔茨海默氏病和其他受抗淀粉样活性影响的病症。
• Aminoacetamide acyl guanidines as β-secretase inhibitors
  申请人：Bristol-Myers Squibb Company

  公开号：US07273882B2

  公开（公告）日：2007-09-25

  There is provided a series of substituted acyl guanidines of Formula (Ik) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R2, R3, R4, R5, R25, R26 and R27 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

  提供一系列经过取代的酰基胍化合物，其化学式为（Ik）或其立体异构体；或其药学上可接受的盐，其中R2、R3、R4、R5、R25、R26和R27的定义如本文所述，以及它们的药物组合物和使用方法。这些化合物抑制β-分泌酶对淀粉样前体蛋白（APP）的加工，更具体地抑制Aβ-肽的产生。本公开涉及的化合物可用于治疗与β-淀粉样蛋白产生有关的神经疾病，例如阿尔茨海默病和受抗淀粉样蛋白活性影响的其他疾病。
• Acyl guanidines as beta-secretase inhibitors
  申请人：Gerritz Samuel

  公开号：US20070015754A1

  公开（公告）日：2007-01-18

  There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 4 and R 5 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

  提供了一系列的取代酰基鸟氨酸化合物（I）或其立体异构体；或其药学上可接受的盐，其中R1、R2、R3、R4和R5如本文所定义，以及它们的药物组合物和使用方法。这些化合物抑制β-分泌酶对淀粉样前体蛋白（APP）的加工，更具体地抑制Aβ-肽的产生。本公开涉及用于治疗与β-淀粉样蛋白产生有关的神经系统疾病，例如阿尔茨海默病和其他受抗淀粉样蛋白活性影响的疾病的化合物。
• Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists
  作者：Miguel Guerrero、Mariangela Urbano、Subash Velaparthi、Jian Zhao、Marie-Therese Schaeffer、Steven Brown、Hugh Rosen、Edward Roberts

  DOI：10.1016/j.bmcl.2011.04.097

  日期：2011.6

  Selective S1P(4) receptor antagonists could be novel therapeutic agents for the treatment of influenza infection in addition to serving as a useful tool for understanding S1P(4) receptor biological functions. 5-(2,5-Dichlorophenyl)-N-(2,6-dimethylphenyl)furan-2-carboxamide was identified from screening the Molecular Libraries-Small Molecule Repository (MLSMR) collection and selected as a promising S1P(4) antagonist hit with moderate in vitro potency and high selectivity against the other family receptor subtypes (S1P(1-3,5)). Rational chemical modifications of the hit allowed the disclosure of the first reported highly selective S1P(4) antagonists with low nanomolar activity and adequate physicochemical properties suitable for further lead-optimization studies. (C) 2011 Elsevier Ltd. All rights reserved.
• US7273882B2
  申请人：——

  公开号：US7273882B2

  公开（公告）日：2007-09-25