9-α-L-rhamnopyranosyladenine | 36807-77-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 9-α-L-rhamnopyranosyladenine
• 英文别名: α-L-rhamnopyranosyladenine；9-L-rhamnopyranosyladenine；1-(6-amino-purin-9-yl)-α-L-1,6-dideoxy-mannopyranose；(6R)-6-(6-amino-purin-9-yl)-2,6-anhydro-1-deoxy-L-mannitol；(6R)-6-(6-Amino-purin-9-yl)-2,6-anhydro-1-desoxy-L-mannit；9-(6-deoxy-α-L-mannopyranosyl)adenin；(2R,3R,4R,5R,6S)-2-(6-aminopurin-9-yl)-6-methyloxane-3,4,5-triol
• CAS: 36807-77-9
• 化学式: C₁₁H₁₅N₅O₄
• 分子量: 281.271
• InChiKey: METOOOPOWVLDNT-ZGAAAFHUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  9-α-L-rhamnopyranosyladenine 在 吡啶 、 溶剂黄146 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 14.0h， 生成 9-(2,3-di-O-benzoyl-α-L-rhamnopyranosyl)hypoxanthine
  参考文献：
  名称：

  Unsaturated ketonucleosides of adenine and hypoxanthine

  摘要：

  DOI：

  10.1016/0008-6215(86)80048-9
• 作为产物：
  描述：

  2,3,4-tri-O-benzoyl-α-L-rhamnopyranosyl bromide 、 alkaline earth salt of/the/ methylsulfuric acid 在 xylene 作用下， 生成 9-α-L-rhamnopyranosyladenine
  参考文献：
  名称：

  Synthesis of Potential Anticancer Agents. VII.² Nucleosides Derived from L-Rhamnopyranose

  摘要：

  DOI：

  10.1021/jo01359a028

文献信息

• EP1611110A1
  申请人：——

  公开号：EP1611110A1

  公开（公告）日：2006-01-04
• Adenosine deaminase inhibitor and novel bacillus sp. iada-7 strain which produces it
  申请人：Lee Gwang

  公开号：US20060211681A1

  公开（公告）日：2006-09-21

  The present invention relates to an adenosine deaminase inhibitor and a novel Bacillus sp. strain which produces it. Particularly, the present 5 invention relates to the adenosine deaminase inhibitor, and the novel Bacillus sp. IADA-7 producing the above adenosine deaminase inhibitor. The adenosine deaminase inhibitor of the present Invention shows superior antibacterial and anticancer activities to the previously reported adenosine deaminase inhibitors.
• US7390800B2
  申请人：——

  公开号：US7390800B2

  公开（公告）日：2008-06-24
• [EN] ADENOSINE DEAMINASE INHIBITOR AND NOVEL BACILLUS SP. IADA-7 STRAIN WHICH PRODUCES IT<br/>[FR] INHIBITEUR D'ADENOSINE DESAMINASE ET NOUVELLE SOUCHE BACILLUS SP. IADA-7 PRODUISANT LEDIT INHIBITEUR
  申请人：PHARMICELL INC

  公开号：WO2004085410A1

  公开（公告）日：2004-10-07

  The present invention relates to an adenosine deaminase inhibitor and a novel Bacillus sp. strain which produces it. Particularly, the present 5 invention relates to the adenosine deaminase inhibitor, and the novel Bacillus sp. IADA-7 producing the above adenosine deaminase inhibitor. The adenosine deaminase inhibitor of the present Invention shows superior antibacterial and anticancer activities to the previously reported adenosine deaminase inhibitors.