ethyl 2-(4-nitrobenzoyl)indolizine-7-carboxylate | 1144047-42-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 2-(4-nitrobenzoyl)indolizine-7-carboxylate
• CAS: 1144047-42-6
• 化学式: C₁₈H₁₄N₂O₅
• 分子量: 338.32
• InChiKey: APAWWRPIGAARPC-UHFFFAOYSA-N

物化性质

• 熔点：
  163-164 °C
• 密度：
  1.33±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  93.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-溴巴豆酸乙酯 、 4-(4-nitrobenzoyl)-1H-pyrrole-2-carbaldehyde 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以86%的产率得到ethyl 2-(4-nitrobenzoyl)indolizine-7-carboxylate
  参考文献：
  名称：

  A Facile Approach to Indolizines via Tandem Reaction

  摘要：

  Indolizines were synthesized by a novel tandem reaction at rt. The operation was simple and convenient. Various indolizine derivatives were obtained in good yields. The reaction mechanism was also proposed.

  DOI：

  10.3987/com-08-11570

文献信息

• A Facile Approach to Indolizines via Tandem Reaction
  作者：Jianwu Wang、Yan-Qing Ge、Jiong Jia、He Yang、Gui-Long Zhao、Fu-Xu Zhan

  DOI：10.3987/com-08-11570

  日期：——

  Indolizines were synthesized by a novel tandem reaction at rt. The operation was simple and convenient. Various indolizine derivatives were obtained in good yields. The reaction mechanism was also proposed.