(2S,3R)-3-tert-Butoxycarbonylamino-4-cyclohexyl-2-hydroxy-butyric acid methyl ester | 728880-24-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (2S,3R)-3-tert-Butoxycarbonylamino-4-cyclohexyl-2-hydroxy-butyric acid methyl ester
• 英文别名: methyl (2S,3R)-4-cyclohexyl-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]butanoate
• CAS: 728880-24-8
• 化学式: C₁₆H₂₉NO₅
• 分子量: 315.41
• InChiKey: PTQHZRAWTDXGKY-OLZOCXBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S,3R)-3-tert-Butoxycarbonylamino-4-cyclohexyl-2-hydroxy-butyric acid methyl ester 在 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 (2S,3R)-3-tert-Butoxycarbonylamino-4-cyclohexyl-2-hydroxy-butyric acid
  参考文献：
  名称：

  Design and synthesis of β-amino-α-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth

  摘要：

  The rational design and synthesis of beta-amino-alpha-hydroxy amide derivatives as reversible inhibitors of methionine aminopeptidase-2 (MetAP2) with anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) is described. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.004
• 作为产物：
  描述：

  (2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoic acid 在 盐酸 、 三乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 为溶剂， 生成 (2S,3R)-3-tert-Butoxycarbonylamino-4-cyclohexyl-2-hydroxy-butyric acid methyl ester
  参考文献：
  名称：

  Design and synthesis of β-amino-α-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth

  摘要：

  The rational design and synthesis of beta-amino-alpha-hydroxy amide derivatives as reversible inhibitors of methionine aminopeptidase-2 (MetAP2) with anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) is described. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.04.004

文献信息

• Renin inhibiting polypeptides and intermediates therefor
  申请人：PFIZER INC.

  公开号：EP0211580A2

  公开（公告）日：1987-02-25

  Polypeptides and derivatives thereof containing oxa- and azahomocyclostatine are useful for inhibiting the angiotensinogen-cleaving action of the enzyme renin.

  含有oxa-和azahomocyclostatine的多肽及其衍生物可用于抑制肾素酶的血管紧张素原分解作用。
• US4599198A
  申请人：——

  公开号：US4599198A

  公开（公告）日：1986-07-08
• US4668769A
  申请人：——

  公开号：US4668769A

  公开（公告）日：1987-05-26
• Design and synthesis of β-amino-α-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth
  作者：Martin Sendzik、James W. Janc、Ronnel Cabuslay、Lee Honigberg、Richard L. Mackman、Catherine Magill、Neil Squires、Nancy Waldeck

  DOI：10.1016/j.bmcl.2004.04.004

  日期：2004.6

  The rational design and synthesis of beta-amino-alpha-hydroxy amide derivatives as reversible inhibitors of methionine aminopeptidase-2 (MetAP2) with anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) is described. (C) 2004 Elsevier Ltd. All rights reserved.