3-(4-Methoxy-1-naphthyl)-1-(4-pyridinyl)-2-propen-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-(4-Methoxy-1-naphthyl)-1-(4-pyridinyl)-2-propen-1-one
• 英文别名: (E)-3-(4-methoxynaphthalen-1-yl)-1-pyridin-4-ylprop-2-en-1-one
• 化学式: C₁₉H₁₅NO₂
• 分子量: 289.334
• InChiKey: ALBGDTTZLJJWIJ-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  吗啉-4-羧酰胺 、 3-(4-Methoxy-1-naphthyl)-1-(4-pyridinyl)-2-propen-1-one 在 air 、 sodium isopropylate 作用下， 以 异丙醇 为溶剂， 反应 8.0h， 生成 4-[4-(4-Methoxynaphthalen-1-yl)-6-pyridin-4-ylpyrimidin-2-yl]morpholine
  参考文献：
  名称：

  Antimalarial activity of 2,4,6-trisubstituted pyrimidines

  摘要：

  A series of 2,4,6-trisubstituted pyrimidines (3a-o) was synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 15 compounds synthesized 11 compounds showed MIC in the range of 0.5-2 mu g/mL. These compounds are in vitro several folds more active than pyrimethamine. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.015
• 作为产物：
  描述：

  4-乙酰吡啶 、 4-甲氧基-1-萘甲醛 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 3-(4-Methoxy-1-naphthyl)-1-(4-pyridinyl)-2-propen-1-one
  参考文献：
  名称：

  Antimalarial activity of 2,4,6-trisubstituted pyrimidines

  摘要：

  A series of 2,4,6-trisubstituted pyrimidines (3a-o) was synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 15 compounds synthesized 11 compounds showed MIC in the range of 0.5-2 mu g/mL. These compounds are in vitro several folds more active than pyrimethamine. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.02.015

文献信息

• Antimalarial activity of 2,4,6-trisubstituted pyrimidines
  作者：Anu Agarwal、Kumkum Srivastava、S.K. Puri、Prem M.S. Chauhan

  DOI：10.1016/j.bmcl.2005.02.015

  日期：2005.4

  A series of 2,4,6-trisubstituted pyrimidines (3a-o) was synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 15 compounds synthesized 11 compounds showed MIC in the range of 0.5-2 mu g/mL. These compounds are in vitro several folds more active than pyrimethamine. (c) 2005 Elsevier Ltd. All rights reserved.