7-oxo-Δ¹⁶-heptadecanoic acid | 65119-96-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 7-oxo-Δ¹⁶-heptadecanoic acid
• 英文别名: 7-Oxo-16-heptadecenoic acid；7-oxo-heptadecenoic acid；7-Oxo-Δ¹⁶-heptadecensaeure；7-Oxo-16-heptadecensaeure-(1)；7-Oxo-heptadec-16-en-1-saeure；7-Oxo-16-heptadecensaeure；7-oxoheptadec-16-enoic acid
• CAS: 65119-96-2
• 化学式: C₁₇H₃₀O₃
• 分子量: 282.423
• InChiKey: KACDBTJUJWBXHM-UHFFFAOYSA-N

物化性质

• 熔点：
  68.5-69.3 °C
• 沸点：
  444.4±38.0 °C(Predicted)
• 密度：
  0.954±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  7-oxo-Δ¹⁶-heptadecanoic acid 在 potassium permanganate 作用下， 以 丙酮 为溶剂， 生成 7-ketohexadecane-1,16-dicarboxylic acid
  参考文献：
  名称：

  大环麝香化合物-IV：十一碳烯酸新合成α，ω-二羧酸和ω-羟基酸

  摘要：

  与烯胺缩合的十一碳十烯酰氯，然后进行环裂解，得到酮-烯酸。后者在黄敏隆还原反应中得到烯酸，而烯酸在氧化时提供了二酸。烯酸的臭氧化，然后将硼氢化钠还原为臭氧化物，得到ω-羟基酸。由此制备了适于转化为大环酮和内酯的C 16和C 15二元酸和ω-羟基酸。

  DOI：

  10.1016/s0040-4020(01)99345-7
• 作为产物：
  描述：

  10-十一碳烯基氯酸 在 氢氧化钾 作用下， 生成 7-oxo-Δ¹⁶-heptadecanoic acid
  参考文献：
  名称：

  大环麝香化合物-IV：十一碳烯酸新合成α，ω-二羧酸和ω-羟基酸

  摘要：

  与烯胺缩合的十一碳十烯酰氯，然后进行环裂解，得到酮-烯酸。后者在黄敏隆还原反应中得到烯酸，而烯酸在氧化时提供了二酸。烯酸的臭氧化，然后将硼氢化钠还原为臭氧化物，得到ω-羟基酸。由此制备了适于转化为大环酮和内酯的C 16和C 15二元酸和ω-羟基酸。

  DOI：

  10.1016/s0040-4020(01)99345-7

文献信息

• Heparanase inhibitors and uses thereof
  申请人：Van Gelder M. Joel

  公开号：US20070185176A1

  公开（公告）日：2007-08-09

  The invention provides heparanase inhibitors suitable for treatment of diseases and disorders caused by or associated with heparanase catalytic activity such as cancer, inflammatory disorders and autoimmune diseases.

  该发明提供了适用于治疗由或与肝素酶催化活性相关的疾病和疾病的肝素酶抑制剂，例如癌症，炎症性疾病和自身免疫疾病。
• A new synthesis of bis-aminoethanethiol (bat) chelating agents containing a gamma carboxylate
  作者：R.H. Mach、H.F. Kung、P. Jungwiwattanaporn、Y.-Z. Guo

  DOI：10.1016/s0040-4039(00)99324-9

  日期：1989.1

  A new synthesis of bis(aminoethanethiols) containing a long-chain fatty acid moiety is described. The procedure described offers an advantage over literature methods since the use of strong reducing agents such as lithium aluminum hydride is avoided.

  描述了含有长链脂肪酸部分的双（氨基乙硫醇）的新合成。由于避免了使用强还原剂（如氢化铝锂），因此所描述的方法相对于文献方法具有优势。
• Phase change inks containing compounds derived from isocyanate, unsaturated alcohol, and polyol
  申请人：Belelie L. Jennifer

  公开号：US20070123641A1

  公开（公告）日：2007-05-31

  Disclosed is a phase change ink comprising a colorant, an initiator, and a phase change ink carrier, said carrier comprising (A) a first isocyanate-derived compound which is the reaction product of a mixture comprising (1) an isocyanate; and (2) a component comprising (a) an alcohol having at least one ethylenic unsaturation; (b) an amine having at least one ethylenic unsaturation; (c) an acid having at least one ethylenic unsaturation; or (d) mixtures thereof, (B) a second isocyanate-derived compound which is the reaction product of (1) a diisocyanate; (2) a monoalcohol having exactly one hydroxyl group and having at least one ethylenic unsaturation; and (3) a polyol having two or more hydroxyl groups, (C) an optional phase change inducing component, said phase change inducing component containing at least one hydroxyl group, said phase change inducing component having a melting point of about 40° C. or higher, and (D) an optional curable viscosity modifying ester, said ink being curable upon exposure to ultraviolet radiation.

  本发明揭示了一种相变墨水，包括颜料、引发剂和相变墨水载体，其中该载体包括(A)第一异氰酸酯衍生物，其是由混合物反应产生的反应产物组成，所述混合物包括(1)异氰酸酯；和(2)包括(a)至少具有一个乙烯基不饱和度的醇；(b)至少具有一个乙烯基不饱和度的胺；(c)至少具有一个乙烯基不饱和度的酸；或(d)其混合物，(B)第二异氰酸酯衍生物，其是(1)二异氰酸酯；(2)恰好具有一个羟基且至少具有一个乙烯基不饱和度的单醇；和(3)具有两个或更多羟基的多元醇的反应产物，(C)可选的相变诱导组分，所述相变诱导组分含有至少一个羟基，其熔点约为40°C或更高，以及(D)可选的可固化粘度调节酯，该墨水在暴露于紫外辐射下可固化。
• Phase change inks containing curable isocyanate-derived compounds and phase change inducing components
  申请人：Belelie L. Jennifer

  公开号：US20070120909A1

  公开（公告）日：2007-05-31

  Disclosed is a phase change ink comprising a colorant, an initiator, and a phase change ink carrier, said carrier comprising (A) a compound which is the reaction product of a mixture comprising (1) an isocyanate; and (2) a component comprising (a) an alcohol having at least one ethylenic unsaturation; (b) an amine having at least one ethylenic unsaturation; (c) an acid having at least one ethylenic unsaturation; or (d) mixtures thereof, (B) a phase change inducing component, said phase change inducing component containing at least one hydroxyl group, said phase change inducing component having a melting point of about 40° C. or higher, and (C) an optional curable viscosity modifying ester, said ink being curable upon exposure to ultraviolet radiation.

  本发明公开了一种相变墨水，包括颜料、引发剂和相变墨水载体，所述载体包括(A)一种化合物，其为混合物的反应产物，所述混合物包括(1)异氰酸酯；和(2)组分，包括(a)至少具有一个乙烯基不饱和度的醇；(b)至少具有一个乙烯基不饱和度的胺；(c)至少具有一个乙烯基不饱和度的酸；或(d)其混合物，(B)相变诱导组分，所述相变诱导组分含有至少一个羟基，所述相变诱导组分的熔点约为40℃或更高，以及(C)可选的可固化粘度调节酯，所述墨水在紫外线辐射下可固化。
• Phase change inks containing curable isocyanate-derived compounds
  申请人：Banning H. Jeffrey

  公开号：US20070123642A1

  公开（公告）日：2007-05-31

  Disclosed is a phase change ink comprising a colorant, an initiator, and a phase change ink carrier, said carrier comprising (A) a urethane which is the reaction product of a mixture comprising (1) an isocyanate; and (2) an alcohol selected from the group consisting of 1,4 butanediol vinyl ether, 2-allyloxy ethanol, 1,4-cyclohexanedimethanol vinyl ether, ethylene glycol vinyl ether, di(ethylene glycol) vinyl ether, and mixtures thereof; (B) a compound which is the reaction product of a mixture comprising (1) an isocyanate; and (2) a component comprising (a) an amine having at least one ethylenic unsaturation; (b) an acid having at least one ethylenic unsaturation; (c) a mixture of an amine having at least one ethylenic unsaturation and an alcohol having at least one ethylenic unsaturation; (d) a mixture of an acid having at least one ethylenic unsaturation and an alcohol having at least one ethylenic unsaturation; or (e) mixtures thereof; or (C) a mixture of (A) and (B); said ink being curable upon exposure to ultraviolet radiation.

  本发明涉及一种相变油墨，包括颜料、引发剂和相变油墨载体，所述载体包括(A)一种聚氨酯，其是以下混合物的反应产物：(1)异氰酸酯；和(2)从1,4-丁二醇乙烯醚、2-烯丙氧乙醇、1,4-环己二甲醇乙烯醚、乙二醇乙烯醚、二(乙二醇)乙烯醚和它们的混合物中选择的醇；(B)一种化合物，其是以下混合物的反应产物：(1)异氰酸酯；和(2)包括(a)至少具有一个乙烯基不饱和的胺；(b)至少具有一个乙烯基不饱和的酸；(c)至少具有一个乙烯基不饱和的胺和至少具有一个乙烯基不饱和的醇的混合物；(d)至少具有一个乙烯基不饱和的酸和至少具有一个乙烯基不饱和的醇的混合物；或(e)它们的混合物；或(C)(A)和(B)的混合物；所述油墨在紫外线辐射下可固化。