2-chloromethyl-1-diethoxymethylindole-6-carbonitrile | 313972-80-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2-chloromethyl-1-diethoxymethylindole-6-carbonitrile
• 英文别名: 2-(Chloromethyl)-1-(diethoxymethyl)indole-6-carbonitrile
• CAS: 313972-80-4
• 化学式: C₁₅H₁₇ClN₂O₂
• 分子量: 292.765
• InChiKey: MOYORMDSWNXQQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  47.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-氯苯基)哌嗪 、 2-chloromethyl-1-diethoxymethylindole-6-carbonitrile 在 polymer-bound 3-benzyloxypropane-1,2-diol 、 对甲苯磺酸 、 盐酸 作用下， 以 1,4-二氧六环 、 N,N-二甲基甲酰胺 为溶剂， 反应 54.0h， 以100%的产率得到2-[4-(2-Chloro-phenyl)-piperazin-1-ylmethyl]-1H-indole-6-carbonitrile
  参考文献：
  名称：

  Cyanoindole Derivatives as Highly Selective Dopamine D₄ Receptor Partial Agonists:  Solid-Phase Synthesis, Binding Assays, and Functional Experiments

  摘要：

  Traceless linking of diethoxymethyl (DEM)-protected 5- and 6-cyanoindoles and subsequent incorporation of phenylpiperazine derivatives led to the 2- and 3-piperazinylmethyl-substituted cyanoindoles 3a-m. Dopamine receptor binding studies on the final products 3a-m clearly indicated strong and selective recognition of the D-4 subtype which is known as a promising target for the treatment of neuropsychiatric disorders. The most interesting binding properties were observed for the 2-aminomethyl-5-cyanoindoles FAUC 299 (3f) and FAUC 316 (3j) (K-i = 0.52 and 1.0 nM, respectively) when the fluoro derivative 3j proved extraordinary selectivity over D-1, D-2long, D-2short, and D-9 (>8600). To determine ligand efficacy, mitogenesis experiments were performed indicating partial agonist effects for the test compounds 3fj (35% and 30%, when compared to the full agonist quinpirole).

  DOI：

  10.1021/jm0009989
• 作为产物：
  描述：

  2-(tert-butyldimethylsilanyloxymethyl)-1-diethoxymethylindole-6-carbonitrile 在 四氯化碳 、 四丁基氟化铵 、 三苯基膦 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 2-chloromethyl-1-diethoxymethylindole-6-carbonitrile
  参考文献：
  名称：

  Cyanoindole Derivatives as Highly Selective Dopamine D₄ Receptor Partial Agonists:  Solid-Phase Synthesis, Binding Assays, and Functional Experiments

  摘要：

  Traceless linking of diethoxymethyl (DEM)-protected 5- and 6-cyanoindoles and subsequent incorporation of phenylpiperazine derivatives led to the 2- and 3-piperazinylmethyl-substituted cyanoindoles 3a-m. Dopamine receptor binding studies on the final products 3a-m clearly indicated strong and selective recognition of the D-4 subtype which is known as a promising target for the treatment of neuropsychiatric disorders. The most interesting binding properties were observed for the 2-aminomethyl-5-cyanoindoles FAUC 299 (3f) and FAUC 316 (3j) (K-i = 0.52 and 1.0 nM, respectively) when the fluoro derivative 3j proved extraordinary selectivity over D-1, D-2long, D-2short, and D-9 (>8600). To determine ligand efficacy, mitogenesis experiments were performed indicating partial agonist effects for the test compounds 3fj (35% and 30%, when compared to the full agonist quinpirole).

  DOI：

  10.1021/jm0009989

文献信息

• VERFAHREN ZUR HERSTELLUNG VON INDOLDERIVATEN AN FESTER PHASE
  申请人：MERCK PATENT GmbH

  公开号：EP1222167A2

  公开（公告）日：2002-07-17
• [DE] VERFAHREN ZUR HERSTELLUNG VON INDOLDERIVATEN AN FESTER PHASE<br/>[EN] METHOD FOR PRODUCING INDOLE DERIVATIVES ON A SOLID PHASE<br/>[FR] PROCEDE DE PREPARATION DE DERIVES D'INDOL SUR UNE PHASE SOLIDE
  申请人：MERCK PATENT GMBH

  公开号：WO2001023353A2

  公开（公告）日：2001-04-05

  Die Erfindung betrifft ein Verfahren zur Herstellung von Indol-Derivaten an fester Phase, wobei die Anbindung an die feste Phase am Indol-Stickstoff durch Transacetalisierung von dialkoxymethylgeschützten Indolen mit einer festen Phase erfolgt, die vicinale Diolgruppen trägt und nach Synthesechemie an der festen Phase, das funktionalisierte Indol-Derivat 'spurlos' von der festen Phase gespalten wird.
• Cyanoindole Derivatives as Highly Selective Dopamine D₄ Receptor Partial Agonists:  Solid-Phase Synthesis, Binding Assays, and Functional Experiments
  作者：Harald Hübner、Johannes Kraxner、Peter Gmeiner

  DOI：10.1021/jm0009989

  日期：2000.11.1

  Traceless linking of diethoxymethyl (DEM)-protected 5- and 6-cyanoindoles and subsequent incorporation of phenylpiperazine derivatives led to the 2- and 3-piperazinylmethyl-substituted cyanoindoles 3a-m. Dopamine receptor binding studies on the final products 3a-m clearly indicated strong and selective recognition of the D-4 subtype which is known as a promising target for the treatment of neuropsychiatric disorders. The most interesting binding properties were observed for the 2-aminomethyl-5-cyanoindoles FAUC 299 (3f) and FAUC 316 (3j) (K-i = 0.52 and 1.0 nM, respectively) when the fluoro derivative 3j proved extraordinary selectivity over D-1, D-2long, D-2short, and D-9 (>8600). To determine ligand efficacy, mitogenesis experiments were performed indicating partial agonist effects for the test compounds 3fj (35% and 30%, when compared to the full agonist quinpirole).