sodium N-(7-chloro-4-quinoyl)-anthranilate | 49713-71-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: sodium N-(7-chloro-4-quinoyl)-anthranilate
• 英文别名: sodium salt of N-(7-chloro-4-quinolyl)-anthranilic acid；N-(7-chloro-4-quinolyl)-anthranilic acid sodium salt；sodium;2-[(7-chloroquinolin-4-yl)amino]benzoate
• CAS: 49713-71-5
• 化学式: C₁₆H₁₀ClN₂O₂*Na
• 分子量: 320.71
• InChiKey: LENZMLNHBQIMIB-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.0
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  sodium N-(7-chloro-4-quinoyl)-anthranilate 生成 N-(7-chloro-4-quinolyl)-anthranilic acid β-(2-oxo-3-oxazolidinyl)-ethyl ester
  参考文献：
  名称：

  NARDI, D.;MOTTA, G.;TESTA, R.;GRAZIANI, G.;CASADIO, S.

  摘要：

  DOI：

文献信息

• Analgesically or anti-inflammatory effective 4-quinolyl anthranilic acid
  申请人：Recordati S.A.

  公开号：US04507308A1

  公开（公告）日：1985-03-26

  The novel anthranilic acid derivatives having the structural formula (I): ##STR1## wherein n is 0, 1 or 2, one of R.sub.1 and R.sub.2 is chloro or trifluoromethyl and the other is hydrogen, and R is 2-oxo-3-oxolanyl or 2-oxo-3-oxazolidinyl, are effective analgesics and anti-inflammatories.

  该小说中的邻氨基苯甲酸衍生物具有结构式（I）：其中n为0、1或2，R.sub.1和R.sub.2中的一个是氯或三氟甲基，另一个是氢，R为2-氧代-3-氧代戊二烯基或2-氧代-3-氧代氮杂环丙烷基，是有效的镇痛剂和抗炎药。
• Therapeutically effective piperidyl
  申请人：Recordati, S. A., Chemical & Pharmaceutical Co.

  公开号：US04482561A1

  公开（公告）日：1984-11-13

  The N-substituted-4-(optionally substituted)-2-, 3- or 4-piperidyl N-(7- or 8-substituted-4-quinolyl)-anthraniloyloxyalkanoates having the structural formula (I): ##STR1## in which R is a straight or branched chain alkyl radical having from 1 to 4 carbon atoms; an alkenyl or alkynyl radical having from 2 to 6 carbon atoms; a benzyl, phenethyl, 4-nitrophenethyl or 4-aminophenethyl radical; or a phenacyl, benzoylethyl, .beta.-hydroxyphenethyl or .alpha.-hydroxyphenylpropyl radical, optionally substituted on the phenyl ring by one or more halogen atom, trifluoromethyl, nitro or amino substituents, or an alkyl substituent having from 1 to 4 carbon atoms or an alkoxy substituent having from 1 to 4 carbon atoms; R.sub.1 is a hydrogen atom or a phenyl radical; each of R.sub.2 and R.sub.3 is independently a hydrogen atom or an alkyl radical having from 1 to 4 carbon atoms; one of R.sub.4 and R.sub.5 is a chlorine atom or a trifluoromethyl radical and the other of R.sub.4 and R.sub.5 is a hydrogen atom; and the pharmaceutically acceptable salts of such esters; are effective analgesics, anti-inflammatories and antidepressants; are also strong inhibitors of platelet aggregation, and thus too are useful in the treatment of cerebral thrombosis, cerebral and cardiac infarction, and arteriosclerotic disorders.

  具有结构式(I)的N-取代-4-(可选择取代)-2、3或4-哌啶基N-(7-或8-取代-4-喹啉基)-蒽酰氧烷酸酯是有效的镇痛剂、抗炎药和抗抑郁药；它们还是强力的血小板聚集抑制剂，因此在治疗脑血栓形成、脑和心肌梗死以及动脉硬化性疾病方面也很有用。其中R是具有1到4个碳原子的直链或支链烷基基团；具有2到6个碳原子的烯基或炔基基团；苄基、苯乙基、4-硝基苯乙基或4-氨基苯乙基基团；或苯乙酰基、苯乙酰乙基、β-羟基苯乙基或α-羟基苯丙基基团，可选择在苯环上通过一个或多个卤素原子、三氟甲基、硝基或氨基取代基，或具有1到4个碳原子的烷基取代基或具有1到4个碳原子的烷氧基取代基；R.sub.1是氢原子或苯基基团；R.sub.2和R.sub.3中的每一个独立地是具有1到4个碳原子的烷基基团；R.sub.4和R.sub.5中的一个是氯原子或三氟甲基基团，另一个是氢原子；以及这些酯的药用盐。
• Anthranilic acid esters
  申请人：RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY

  公开号：EP0076600A1

  公开（公告）日：1983-04-13

  Anthranilic acid esters I have analgesic and anti-inflammatory properties. They are prepared by condensing a salt (preferably Na) of an N-(7- or 8-substituted-4-quinolyl)-anthranilic acid with a haloderiva- tive Halo-(CH2)n-R. The condensation conditions are suitably equimolar proportion, 30 to 150°C, DMF as solvent. Pharmaceutical preparations are also disclosed.

  蒽酸酯 I 具有镇痛和消炎作用，其制备方法是将 N-(7-或 8-取代的-4-喹啉基)-蒽酸的盐(最好是 Na)与卤代-(CH2)n-R 缩合。 缩合条件为适当的等摩尔比例、30 至 150°C、DMF 作为溶剂。 还公开了药物制剂。
• Soeder, Alfons; Perrey, Klaus, Polish Journal of Chemistry, 1980, vol. 54, # 6, p. 1305 - 1311
  作者：Soeder, Alfons、Perrey, Klaus

  DOI：——

  日期：——
• SOEDER A.; PERREY K., POL. J. CHEM., 1980, 54, NO 6, 1305-1311
  作者：SOEDER A.、 PERREY K.

  DOI：——

  日期：——