10-[4-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]butyl]acridin-9-one | 1067275-06-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 10-[4-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]butyl]acridin-9-one
• CAS: 1067275-06-2
• 化学式: C₃₀H₃₃N₃O
• 分子量: 451.612
• InChiKey: IGIPNSFQYHDERB-JLHYYAGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  26.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  肉桂基哌嗪 、 10-(4-bromobutyl)acridin-9(10H)-one 在 sodium hydroxide 、 四丁基溴化铵 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 24.0h， 生成 10-[4-[4-[(E)-3-phenylprop-2-enyl]piperazin-1-yl]butyl]acridin-9-one
  参考文献：
  名称：

  Structure–activity relationship studies of the chromosome segregation inhibitor, Incentrom A

  摘要：

  A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.07.006

文献信息

• Structure–activity relationship studies of the chromosome segregation inhibitor, Incentrom A
  作者：Hee-Yoon Lee、Yongsik Jung、Wonyeob Kim、Jin Hee Kim、Min-Soo Suh、Seung Koo Shin、Hye-Joo Yoon

  DOI：10.1016/j.bmcl.2008.07.006

  日期：2008.8

  A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established. (C) 2008 Elsevier Ltd. All rights reserved.