2-amino-4′-aminoacetophenone | 875815-18-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-amino-4′-aminoacetophenone
• 英文别名: 1-(2,4-diamino-phenyl)-ethanone；1-(2,4-Diamino-phenyl)-aethanon；1-(2,4-Diaminophenyl)ethanone
• CAS: 875815-18-2
• 化学式: C₈H₁₀N₂O
• 分子量: 150.18
• InChiKey: LDEYHTYHAWGIFG-UHFFFAOYSA-N

物化性质

• 熔点：
  136-137 °C
• 沸点：
  368.4±22.0 °C(Predicted)
• 密度：
  1.196±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  69.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-4′-aminoacetophenone 在 (R)-epinephrine dehydrogenase 、 还原型辅酶Ⅰ 作用下， 以 aq. phosphate buffer 为溶剂， 生成 1-hydroxyethyl-2,4-diaminobenzene
  参考文献：
  名称：

  Purification and characterization of a novel carbonyl reductase involved in oxidoreduction of aromatic β-amino ketones/alcohols

  摘要：

  Aromatic beta-amino ketones/alcohols such as adrenalone play an important role in some stereoselective synthesis of pharmaceuticals. Unfortunately, the transformation of aromatic beta-amino ketones to their chiral alcohols has been carried out chemically as no corresponding biocatalyst has been available. Here, a novel carbonyl reductase responsible for the reduction of adrenalone to (R)-(-)-epinephrine was identified and characterized from Kocuria rhizophila. This enzyme was purified to homogeneity by ammonium sulfate precipitation followed by ion-exchange column chromatography, hydrophobic chromatography and gel chromatography. The purified enzyme yielded pure (R)-enantiomer product with high activity and utilized NADH as the cofactor. The enzyme had special significance by showing selectivity for many aromatic beta-amino ketones/alcohols such as 2-amino-acetophenone, 2-amino-4'-hydroxyacetophenone, isoproterenol and ephedrine. The maximum reaction rate (V-max) and apparent Michaelis-Menten constant (K-m) for adrenalone and NADH were 14.62 mu mol/(min mg) protein and 0.189 mM, 11.66 mu mol/(min mg) protein and 0.204 mM respectively. These properties ensure the enzyme a promising future for industrial application as a replacement of chemical synthesis of aromatic beta-amino chiral alcohols. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.procbio.2014.03.023
• 作为产物：
  描述：

  1-(2-氨基-4-硝基苯基)乙酮 生成 2-amino-4′-aminoacetophenone
  参考文献：
  名称：

  837.衍生自芳香胺和2-羟基酮的吲哚。7-乙酰基-2：3：4'：5'-四苯基吡咯并（2'：3'-4：5）-吲哚的合成

  摘要：

  DOI：

  10.1039/jr9530004114

文献信息

• [EN] KIF18A INHIBITORS<br/>[FR] INHIBITEURS DE KIF18A
  申请人：AMGEN INC

  公开号：WO2021026098A1

  公开（公告）日：2021-02-11

  Amide compounds of formula (I): and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of Kinesin Motor Protein KIF18A, such as cancer, psoriasis, atopic dermatitis, an autoimmune disorder, or inflammatory bowel disease, and the like.

  化合物的酰胺类化合物（I）的化学式：以及含有它们的组合物，以及制备这种化合物的方法。本文还提供了治疗通过抑制Kinesin Motor Protein KIF18A可治疗的疾病或疾病的方法，如癌症，牛皮癣，特应性皮炎，自身免疫性疾病或炎症性肠病等。
• Novel Boronic Chalcone Derivatives and Uses Thereof
  申请人：Khan Saeed R.

  公开号：US20090227542A1

  公开（公告）日：2009-09-10

  The present invention relates to novel boronic chalcone derivatives which are useful as antitumor/anticancer agents. The present compounds, which are inexpensive to synthesize, exhibit unexpectedly good inhibitors of the growth of human breast cancer cells. The present invention also relates to the use of the novel boronic chalcone derivatives to treat cancer. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of cancer.

  本发明涉及一种新颖的硼酸查尔酮衍生物，其可用作抗肿瘤/抗癌剂。这些新化合物不仅易于合成，而且表现出出乎意料的良好抑制人类乳腺癌细胞生长的效果。本发明还涉及使用这些新颖的硼酸查尔酮衍生物来治疗癌症。该发明还提供了包含本发明所述抑制剂的制药组合物，以及利用这些抑制剂和制药组合物在癌症的治疗和预防中的方法。
• Verwendung von Benzimidazolderivaten als Leistungsförderer
  申请人：BAYER AG

  公开号：EP0325802A1

  公开（公告）日：1989-08-02

  Die vorliegende Erfindung betrifft die Verwendung von Benzimidazolderivaten der Formel in welcher R¹ für Wasserstoff, Hydroxy, Alkyl, Halogenalkyl steht, R² für Wasserstoff, Alkyl, Halogen, CN, Halogenalkyl steht, R³ für Wasserstoff, Alkyl, Acyl steht, R⁴ für Wasserstoff, Alkyl, Halogenalkyl steht, R⁵ für Alkyl, Halogenalkyl steht, R⁶ für Alkyl, Cycloalkyl, gegebenenfalls substituiert durch Halogen, Cycloalkyl, OH, Alkoxy, Halogen­alkoxy, Aryl, das seinerseits substituiert sein kann durch Alkyl, Halogen, CN oder die Reste -COR⁷, -O-Alkylen-COR⁷, -Alkylen-R⁸ oder -O-Alkylen-R⁸, steht, R⁷ für Hydroxy, Alkoxy oder -NR⁹R¹⁰ steht, R⁸ für Hydroxy, Alkoxy oder -NR⁹R¹⁰ steht, R⁹ für Wasserstoff, Alkyl steht, R¹⁰ für Wasserstoff, Alkyl steht sowie deren Tautomere and physiologisch verträgliche Salze als Leistungsförderer für Tiere, neue Benzimid­azolderivate, Zwischenprodukte und Verfahren zu ihrer Herstellung.

  本发明涉及使用式中的苯并咪唑衍生物 其中 R¹代表氢、羟基、烷基、卤代烷基、 R² 代表氢、烷基、卤素、CN、卤代烷基、 R³ 是氢、烷基、酰基、 R⁴ 是氢、烷基、卤代烷基、 R⁵ 是烷基、卤代烷基、 R⁶ 是烷基、环烷基，可任选被卤素、环烷基、OH、烷氧基、卤代烷氧基、芳基取代，而芳基又可被烷基、卤素、CN 或 -COR⁷、-O-亚烷基-COR⁷、-亚烷基-R⁸ 或 -O- 亚烷基-R⁸ 取代、 R⁷ 是羟基、烷氧基或-NR⁹R¹⁰、 R⁸ 是羟基、烷氧基或 -NR⁹R¹⁰、 R𠞙 代表氢、烷基、 R¹⁰代表氢、烷基 以及它们的同系物和生理相容盐作为动物的性能增强剂、新的苯并咪唑衍生物、中间体及其制备工艺。
• POSITIVE PHOTOSENSITIVE POLYIMIDE COMPOSITION
  申请人：PI R & D Co Ltd

  公开号：EP1024407A1

  公开（公告）日：2000-08-02

  A photosensitive polyimide composition which is soluble in an organic solvent, which is excellent in adhesiveness, heat resistance, mechanical properties and flexibility, which shows the property of highly sensitive positive-type photoresist that is soluble in alkali upon irradiation with light is disclosed. The polyimide composition of the present invention contains a photoacid generator and a solvent-soluble polyimide which shows positive-type photosensitivity in the presence of said photoacid generator.

  本发明公开了一种可溶于有机溶剂的光敏聚酰亚胺组合物，该组合物具有优异的粘合性、耐热性、机械性能和柔韧性，在光照射下显示出可溶于碱的高灵敏度正型光刻胶特性。本发明的聚酰亚胺组合物包含一种光酸发生器和一种可溶于溶剂的聚酰亚胺，该聚酰亚胺在所述光酸发生器的存在下显示出正型光敏性。
• NEGATIVE PHOTOSENSITIVE POLYIMIDE COMPOSITION AND METHOD OF FORMING IMAGE FROM THE SAME
  申请人：PI R & D Co., Ltd.

  公开号：EP1326138A1

  公开（公告）日：2003-07-09

  Disclosed is a composition of a negative-type photosensitive polyimide which is solvent soluble, which is excellent in adhesiveness, heat resistance, mechanical properties and in flexibility, which shows characteristics of alkali-soluble highly sensitive negative-type photoresist upon irradiation with light. The composition according to the present invention comprises a photo radical initiator and a solvent-soluble polyimide which shows negative-type photosensitivity in the presence of the photo radical initiator.

  本发明公开了一种负型光敏聚酰亚胺组合物，该组合物溶于溶剂，具有优异的粘合性、耐热性、机械性能和柔韧性，在光照射下显示出碱溶性高灵敏度负型光刻胶的特性。根据本发明的组合物包括一种光自由基引发剂和一种可溶于溶剂的聚酰亚胺，在光自由基引发剂的存在下，该聚酰亚胺显示出负型光敏性。