1-((benzyloxy)thiocarbamoyl)imidazole | 114324-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-((benzyloxy)thiocarbamoyl)imidazole
• 英文别名: O-benzyl imidazole-1-carbothioate
• CAS: 114324-59-3
• 化学式: C₁₁H₁₀N₂OS
• 分子量: 218.279
• InChiKey: RINDKWISUHSZGZ-UHFFFAOYSA-N

物化性质

• 沸点：
  366.9±35.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  59.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-((benzyloxy)thiocarbamoyl)imidazole 、 N-甲基苄胺 以 乙腈 为溶剂， 生成 O-benzyl N-benzyl-N-methylthiocarbamate
  参考文献：
  名称：

  Activation of dithiocarbamate by 2-halothiazolium salts

  摘要：

  DOI：

  10.1021/jo00245a025
• 作为产物：
  描述：

  咪唑 、 二硫化碳 、 苯甲醇 生成 1-((benzyloxy)thiocarbamoyl)imidazole
  参考文献：
  名称：

  Activation of dithiocarbamate by 2-halothiazolium salts

  摘要：

  DOI：

  10.1021/jo00245a025

文献信息

• Molecularly imprinted polymer nanoparticles compatible with biological samples and preparation method thereof
  申请人：Nankai University

  公开号：US10053531B2

  公开（公告）日：2018-08-21

  This invention provides molecularly imprinted polymer nanoparticles compatible with biological samples, and in particular pure biological samples and a preparation method thereof. Said molecularly imprinted polymer nanoparticles have a crosslinking degree exceeding 50%, a particle diameter of 10 to 500 nm, hydrophilic polymer brushes on its surfaces and can be prepared by introducing appropriate hydrophilic macromolecular chain transfer agents into reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization systems through the one-pot synthesis. The preparation method is simple, features a broad range of application and yields a pure product. The obtained hydrophilic molecularly imprinted polymer nanoparticles have prospects for a wide range of application in biological sample analysis, medical clinical immune analysis, food and environmental monitoring, biomimetic sensors, etc.

  本发明提供了与生物样品，特别是纯生物样品相容的分子印迹聚合物纳米粒子及其制备方法。所述分子印迹聚合物纳米颗粒的交联度超过 50%，颗粒直径为 10 至 500 nm，表面具有亲水性聚合物刷，可通过在可逆加成-碎片链转移（RAFT）沉淀聚合体系中引入适当的亲水性大分子链转移剂，采用一锅合成法制备。该制备方法简单、应用范围广、产物纯度高。所获得的亲水性分子印迹聚合物纳米粒子在生物样品分析、医学临床免疫分析、食品和环境监测、仿生传感器等方面具有广泛的应用前景。
• MOLECULARLY IMPRINTED POLYMER NANOPARTICLES COMPATIBLE WITH BIOLOGICAL SAMPLES AND PREPARATION METHOD THEREOF
  申请人：Nankai University

  公开号：US20150299366A1

  公开（公告）日：2015-10-22

  This invention provides molecularly imprinted polymer nanoparticles compatible with biological samples, and in particular pure biological samples and a preparation method thereof. Said molecularly imprinted polymer nanoparticles have a crosslinking degree exceeding 50%, a particle diameter of 10 to 500 nm, hydrophilic polymer brushes on its surfaces and can be prepared by introducing appropriate hydrophilic macromolecular chain transfer agents into reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization systems through the one-pot synthesis. The preparation method is simple, features a broad range of application and yields a pure product. The obtained hydrophilic molecularly imprinted polymer nanoparticles have prospects for a wide range of application in biological sample analysis, medical clinical immune analysis, food and environmental monitoring, biomimetic sensors, etc.
• MOLECULARLY IMPRINTED PARTICLES
  申请人：GEORGE MASON UNIVERSITY

  公开号：US20200363421A1

  公开（公告）日：2020-11-19

  Molecularly imprinted particles comprising a label are described herein, in particular such particles prepared by RAFT polymerization, as are compositions and kits comprising such particles, and methods for preparing and using such particles.