2-Diazo-1,3-diphenylpropane | 166264-26-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-Diazo-1,3-diphenylpropane
• 英文别名: Benzene, 1,1'-(2-diazo-1,3-propanediyl)bis-；(2-diazo-3-phenylpropyl)benzene
• CAS: 166264-26-2
• 化学式: C₁₅H₁₄N₂
• 分子量: 222.29
• InChiKey: LITPELIOTFCRQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Diazo-1,3-diphenylpropane 反应 72.0h， 生成 cis-1,3-diphenylpropene 、 (1E)-1,3-diphenylpropene 、 bis-(1-benzyl-2-phenyl-ethylidene)-hydrazine
  参考文献：
  名称：

  5,5-二苄基-Δ3-1,3,4-恶二唑啉的光解

  摘要：

  在乙炔二甲酸二甲酯 (DMAD) 存在下二苄基-Δ3-1,3,4-恶二唑啉 (3) 的光解仅产生预期的对称 3,3-二苄基环丙烯 (4) 的适度产率，但这些伴随着超过六个副产物，包括不对称环丙烯、亚甲基环丙烷和各种吡唑。这一系列产品的起源可以通过一系列步骤来解释，从 3 的光解开始形成重氮烷，该重氮烷经过 1,3-偶极环加成到 DMAD，生成 3H-吡唑作为初始产物。后者通过热 1,5-sigmatropic 或离子对重排进一步光解为对称的环丙烯，与苄基迁移竞争，得到 4H-吡唑。4H-吡唑依次经过光解生成不对称的环丙烯，重排为亚甲基环丙烷。4H-吡唑也在空气存在下进行自氧化，得到苯甲酰基-4H-吡唑。此外，在与重排的竞争中，v...

  DOI：

  10.1139/v97-033
• 作为产物：
  描述：

  三丁基[(环己-1-烯-1-基甲氧基)甲基]锡烷 在 lead(IV) acetate 、 1,1,2,3-四甲基胍 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以96%的产率得到2-Diazo-1,3-diphenylpropane
  参考文献：
  名称：

  Advantageous Syntheses of Diazo Compounds by Oxidation of Hydrazones with Lead Tetraacetate in Basic Environments

  摘要：

  Varied sensitive diazo compounds 3 are produced efficiently and safely in 3-6 g quantities by oxidation (eq 1) of hydrazones 1 at -78 degrees C with lead tetraacetate (2) in triethylamine/chloroform, N-methylmorpholine/dimethylformamide, tetramethylguanidine (8)/dimethylformamide, and tetramethylguanidine/methylene chloride, respectively, upon use of appropriate workup and handling techniques. New and improved nonhazardous procedures have been developed for preparing and handling hydrazones 1 from aldehydes and ketones in reactions with excess hydrazine.

  DOI：

  10.1021/jo00120a013

文献信息

• Process for Labeling and Purification of Nucleic Acids of Interest Present in a Biological Sample to be Treated in a Single Reaction Vessel
  申请人：Laayoun Ali

  公开号：US20080233632A1

  公开（公告）日：2008-09-25

  The present invention relates to a process for labeling and purification of nucleic acids of interest present in a biological sample to be treated, comprising: taking a single reaction vessel, introducing into the reaction vessel: the biological sample, at least one labeling reagent for nucleic acids, at least one solid support enabling the adsorption of said nucleic acids, any ingredient necessary for the labeling of the nucleic acids and/or for the immobilization of said nucleic acids on the support, incubating the contents of the reaction vessel, and isolating the nucleic acids thus labeled. The invention finds a preferred application in the diagnostics field.

  本发明涉及一种用于标记和纯化生物样品中感兴趣的核酸的方法，包括：取一个反应容器，将以下物质引入反应容器中：生物样品，至少一种核酸标记试剂，至少一种固体支持物，能够吸附该核酸，任何必要的成分用于标记核酸和/或将该核酸固定在支持物上，孵育反应容器的内容，然后分离标记的核酸。该发明在诊断领域中具有优选应用。
• Labeling Reagents, Methods for the Synthesis of Such Reagents and Methods for the Detection of Biological Molecules
  申请人：Laayoun Ali

  公开号：US20080032288A1

  公开（公告）日：2008-02-07

  The present invention relates to a temperature-stable labeling reagent of formula (0): in which: R 1 represents H or an alkyl, aryl or substituted aryl group, R 2 represents a detectable marker or at least two detectable markers interlinked by at least one multimeric structure, L is a linker arm comprising a linear chain of at least two covalent bonds and n is an integer equal to 0 or 1, R 3 and R 4 represent, independently of one another: H, NO 2 , Cl, Br, F, I, R 2 —(L) n —Y—X—, OR, SR, NR 2 , R, NHCOR, CONHR, COOR, —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 3 -CH 2 —NH—R 2 , —CO—NH—(CH 2 ) 3 —(O—CH 2 —CH 2 ) 4 —CH 2 —NH—R 2 with R=alkyl or aryl, A is a linker arm comprising at least one covalent double bond enabling the conjugation of the diazo function with the aromatic ring and u is an integer between 0 and 2 , preferably 0 or 1, —Y—X— represents —CONH—, —NHCO—, —CH 2 O—, —CH 2 S—, -Z-represents —NH—, —NHCO—, —CONH— or —O—, m is an integer between 1 and 10 , preferably between 1 and 3 , and p is an integer between 1 and 10 , preferably between 1 and 3. The present invention also describes a method for the synthesis of said labels and also applications for the labeling of biological molecules, in particular of nucleic acids, with a labeling reagent bearing the diazomethyl function. The invention is particularly suitable for use in the field of diagnostics.
• US7338805B2
  申请人：——

  公开号：US7338805B2

  公开（公告）日：2008-03-04
• US7691635B2
  申请人：——

  公开号：US7691635B2

  公开（公告）日：2010-04-06
• Photolysis of 5,5-dibenzyl-Δ³-1,3,4-oxadiazolines
  作者：John Warkentin、John Mck.R. Woollard

  DOI：10.1139/v97-033

  日期：1997.3.1

  Photolysis of dibenzyl-Δ3-1,3,4-oxadiazolines (3) in the presence of dimethyl acetylenedicarboxylate (DMAD) gives only modest yields of the expected symmetrical 3,3-dibenzylcyclopropenes (4), but these are accompanied by more than six by-products, including unsymmetrical cyclopropenes, methylenecyclopropanes, and various pyrazoles. The origin of this array of products can be explained by a series of

  在乙炔二甲酸二甲酯 (DMAD) 存在下二苄基-Δ3-1,3,4-恶二唑啉 (3) 的光解仅产生预期的对称 3,3-二苄基环丙烯 (4) 的适度产率，但这些伴随着超过六个副产物，包括不对称环丙烯、亚甲基环丙烷和各种吡唑。这一系列产品的起源可以通过一系列步骤来解释，从 3 的光解开始形成重氮烷，该重氮烷经过 1,3-偶极环加成到 DMAD，生成 3H-吡唑作为初始产物。后者通过热 1,5-sigmatropic 或离子对重排进一步光解为对称的环丙烯，与苄基迁移竞争，得到 4H-吡唑。4H-吡唑依次经过光解生成不对称的环丙烯，重排为亚甲基环丙烷。4H-吡唑也在空气存在下进行自氧化，得到苯甲酰基-4H-吡唑。此外，在与重排的竞争中，v...