5-(4-phenylphenyl)-2-furaldehyde | 41373-29-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(4-phenylphenyl)-2-furaldehyde
• 英文别名: 5-(biphenyl-4-yl)furan-2-carbaldehyde；5-([1,1'-biphenyl]-4-yl)furan-2-carbaldehyde；5-(4-Phenylphenyl)furan-2-carbaldehyde
• CAS: 41373-29-9
• 化学式: C₁₇H₁₂O₂
• 分子量: 248.281
• InChiKey: NLIWQGBZXVLRRA-UHFFFAOYSA-N

物化性质

• 熔点：
  137-140 °C
• 沸点：
  455.1±33.0 °C(Predicted)
• 密度：
  1.157±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-(4-phenylphenyl)-2-furaldehyde 在 哌啶 、 一水合肼 作用下， 以 乙醇 、 水 为溶剂， 70.0 ℃ 、1.31 MPa 条件下， 反应 1.0h， 生成 5-(5-([1,1'-biphenyl]-4-yl)furan-2-yl)-3-(3-bromophenyl)-4,5-dihydro-1H-pyrazole
  参考文献：
  名称：

  Novel Furan-2-yl-1H-pyrazoles Possess Inhibitory Activity against α-Synuclein Aggregation

  摘要：

  A series of novel furan-2-y1-1H-pyrazoles and their chemical precursors were synthesized and evaluated for their effectiveness at disrupting alpha-synuclein (alpha-syn) aggregation in vitro. The compounds were found to inhibit alpha-syn aggregation with efficacy comparable to the promising drug candidate anle138b. The results of this study indicate that compounds 8b, 8l, and 9f may qualify as secondary leads for the structure-activity relationship studies aimed to identify the suitable compounds for improving the modulatory activity targeted at alpha-syn self-assembly related to Parkinson's disease.

  DOI：

  10.1021/acschemneuro.0c00252
• 作为产物：
  描述：

  5-甲醛基呋喃-2-硼酸 、 4-溴代联苯 在 bis-triphenylphosphine-palladium(II) chloride sodium carbonate 作用下， 以 乙二醇二甲醚 为溶剂， 反应 9.0h， 生成 5-(4-phenylphenyl)-2-furaldehyde
  参考文献：
  名称：

  tauopathy细胞模型中基于罗丹宁的tau聚集抑制剂。

  摘要：

  DOI：

  10.1002/anie.200704051

文献信息

• Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation
  作者：Anzhalika Sidarovich、Cindy L Will、Maria M Anokhina、Javier Ceballos、Sonja Sievers、Dmitry E Agafonov、Timur Samatov、Penghui Bao、Berthold Kastner、Henning Urlaub、Herbert Waldmann、Reinhard Lührmann

  DOI：10.7554/elife.23533

  日期：——

  the stalled complexes (designated B028) revealed that U4/U6 snRNP proteins are released during activation before the U6 Lsm and B-specific proteins, and before recruitment and/or stable incorporation of Prp19/CDC5L complex and other Bact complex proteins. The U2/U6 RNA network in B028 complexes differs from that of the Bact complex, consistent with the idea that the catalytic RNA core forms stepwise

  前 mRNA 剪接的小分子抑制剂是识别新剪接体组装中间体的重要工具，可以更精细地剖析剪接体动力学和功能。在这里，我们鉴定了一种小分子，它在前催化剪接体 B 复合物转化为活化的 Bact 复合物的中间阶段抑制人前体 mRNA 剪接。停滞复合物（指定为 B028）的表征表明，U4/U6 snRNP 蛋白在 U6 Lsm 和 B 特异性蛋白之前的激活过程中以及在 Prp19/CDC5L 复合物和其他 Bact 复合物蛋白的募集和/或稳定掺入之前释放。B028 复合物中的 U2/U6 RNA 网络与 Bact 复合物中的不同，与催化 RNA 核心在 B 到 Bact 过渡期间逐步形成的想法一致，并且可能由 Prp19/CDC5L 复合物和相关蛋白质稳定。总之，我们的数据为剪接体激活过程中发生的 RNP 重排和广泛的蛋白质交换提供了新的见解。DOI：http://dx.doi.org/10.7554/eLife
• Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle
  作者：Takamitsu Hosoya、Hiroshi Aoyama、Takaaki Ikemoto、Yasutaka Kihara、Toshiyuki Hiramatsu、Makoto Endo、Masaaki Suzuki

  DOI：10.1016/s0968-0896(02)00600-4

  日期：2003.3

  The general synthesis of dantrolene analogues with various substituents on its phenyl ring has been developed via palladium-catalyzed cross-coupling reactions, the Stille or Suzuki reaction, as the key step. The effects of synthesized analogues have been evaluated by two kinds of Ca2+ release modes from sarcoplasmic reticulum (SR) of mouse skeletal muscle fibers based on: (1) the measurement of twitch contraction caused by the physiological Ca2+ release (PCR) of intact skeletal muscle and (2) the rate of Ca2+-induced Ca2+ release (CICR) in saponin-treated skinned muscle fibers. Although dantrolene, a lead compound, inhibits both twitch contraction and CICR, some structurally modified analogues exhibit one or the other of these effects. The methoxy congener, GIF-0185, potently inhibits the twitch contraction without affecting the CICR, while GIF-0166 and GIF-0248, the ortho-nitro regioisomer and ortho, ortho-dinitro substituted analogues, respectively, doubly potentiate the CICR exclusively. (C) 2002 Elsevier Science Ltd. All rights reserved.
• Preparation of 5-Aryl Furfurals and Aryl Thiophene-2-carboxaldehydes via Palladium-Catalyzed C−C Bond Formation in Aqueous Media¹
  作者：Jacqueline C. Bussolari、Diana C. Rehborn

  DOI：10.1021/ol990708m

  日期：1999.10.1

  [GRAPHICS]A series of 5-aryl furfurals and aryl thiophene-2-carboxaldehydes was synthesized. To this end, efficient and effective palladium-catalyzed C-C bond-forming reactions were carried out at room temperature in aqueous media. This mild process allowed the cross-coupling reaction of the bromides to occur in the presence of electrophilic functional groups, which is a valuable advantage over previously reported methods.
• Hetarylethylene derivatives of 2,5-diphenyloxazole
  作者：B. M. Krasovitskii、S. V. Tsukerman、L. Sh. Afanasiadi、V. K. Polyakov、N. P. Egorova、E. M. Shaulova

  DOI：10.1007/bf00469884

  日期：1977.12
• KRASOVITSKIJ B. M.; TSUKERMAN S. V.; AFANASIADI L. SH.; POLYAKOV V. K.; E+, XIMIYA GETEROTSIKL. SOEDIN., 1977, HO 12, 1616-1618
  作者：KRASOVITSKIJ B. M.、 TSUKERMAN S. V.、 AFANASIADI L. SH.、 POLYAKOV V. K.、 E+

  DOI：——

  日期：——