7-羟甲基苯并(a)蒽 | 16110-13-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 7-羟甲基苯并(a)蒽
• 英文名称: 7-hydroxy-methyl-12-benz[a]anthracene
• 英文别名: 7-hydroxymethyl-benz[a]anthracene；7-Hydroxymethyl-benz[a]anthracen；7-Hydroxymethylbenzanthracen；7-Hydroxymethylbenz(a)anthracene；benzo[a]anthracen-7-ylmethanol
• CAS: 16110-13-7
• 化学式: C₁₉H₁₄O
• 分子量: 258.32
• InChiKey: FWFOOWHDKQMDKI-UHFFFAOYSA-N

物化性质

• 熔点：
  >198°C (dec.)
• 沸点：
  361.57°C (rough estimate)
• 密度：
  1.0651 (rough estimate)
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2905290000

SDS

制备方法与用途

类别：有毒物品
储运特性：通风、低温、干燥

灭火剂：干粉、泡沫、沙土、二氧化碳、雾状水

反应信息

• 作为反应物：
  描述：

  7-羟甲基苯并(a)蒽 在 氢溴酸 作用下， 生成 7-溴甲基苯并蒽
  参考文献：
  名称：

  混合双功能。4.多环芳烃的烷基化衍生物的抗肿瘤活性作为结构和载体的函数。

  摘要：

  DOI：

  10.1021/jm00271a018
• 作为产物：
  描述：

  7-(氯甲基)苯并[a]蒽 在 sodium hydroxide 、 溶剂黄146 作用下， 生成 7-羟甲基苯并(a)蒽
  参考文献：
  名称：

  170.抑制生长的多环化合物的合成。第一部分

  摘要：

  DOI：

  10.1039/jr9390000802

文献信息

• Dansik; Vercellone, Chemische Berichte, 1939, vol. 72, p. 1457,1458
  作者：Dansik、Vercellone

  DOI：——

  日期：——
• Multi-stage stem cell carcinogenesis
  申请人：Krtolica Ana

  公开号：US20100162416A1

  公开（公告）日：2010-06-24

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
• [EN] MULTI-STAGE STEM CELL CARCINOGENESIS<br/>[FR] CARCINOGENESE DE CELLULES SOUCHES MULTIETAPES
  申请人：STEMLIFELINE INC

  公开号：WO2010037134A2

  公开（公告）日：2010-04-01

  The present invention relates to a system of multi-stage stem cell carcinogenesis and a method of generating such multi-stage stem cell carcinogenesis system. Various stages of cancer stem cells can be generated from normal stem cells via mutagenesis. The system of the present invention enables monitoring changes in the ability of cells to transition from one stage of carcinogenesis to another and to identify genetic pathways and molecules that influence carcinogenesis. The present invention also enables a high-throughput and nonbiased screening for targets that preferentially affect cancer stem cells relative to non-cancer stem cells or their derivatives during stem cell carcinogenesis, thus is useful in developing anti-cancer therapeutics.
• Mixed bifunctionality. 4. Antitumor activity of alkylating derivatives of polycyclic aromatic hydrocarbons as a function of structure and of vehicle
  作者：Richard M. Peck、Anna P. O'Connell

  DOI：10.1021/jm00271a018

  日期：1972.1
• 170. The synthesis of growth-inhibitory polycyclic compounds. Part I
  作者：G. M. Badger、J. W. Cook

  DOI：10.1039/jr9390000802

  日期：——