7-溴甲基苯并蒽 | 24961-39-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 中文名称: 7-溴甲基苯并蒽
• 中文别名: N-(甲磺酰)-D-己氨酰&lt正白氨酰&gt-N-{(2S)-5-[(二氨基甲亚基)氨基]-2-[(4-硝基苯基)氨基]戊酰基}甘氨酸酰胺
• 英文名称: 7-Brommethyl-benz[a]anthracen
• 英文别名: 7-Brommethylbenzanthracen；7-bromomethyl-benz[a]anthracene；7-Bromomethylbenzanthracene；7-(bromomethyl)benzo[a]anthracene
• CAS: 24961-39-5
• 化学式: C₁₉H₁₃Br
• 分子量: 321.216
• InChiKey: QUVSFZCWYBQJJK-UHFFFAOYSA-N

物化性质

• 沸点：
  376.83°C (rough estimate)
• 密度：
  1.3694 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2903999090

SDS

制备方法与用途

类别：有毒物质

毒性分级：剧毒

急性毒性：静脉-小鼠 LD₅₀: 1.6 毫克/公斤

可燃性危险特性：热分解时排出有毒溴化物烟雾

储运特性：库房通风、低温干燥；与食品原料类分开存放

灭火剂：水、干粉、干砂、二氧化碳、泡沫、1211灭火剂

反应信息

• 作为产物：
  描述：

  7-甲基苯[a]蒽 在 二硫化碳 、 溴 作用下， 生成 7-溴甲基苯并蒽
  参考文献：
  名称：

  Thiocyanation of Carcinogenic Hydrocarbons

  摘要：

  DOI：

  10.1021/ja01854a008

文献信息

• Nitrilases, nucleic acids encoding them and methods for making and using them
  申请人：Diversa Corporation

  公开号：US20040014195A1

  公开（公告）日：2004-01-22

  The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

  该发明涉及腈酶和编码腈酶的核酸。此外还提供了设计新腈酶的方法以及使用该方法的方法。这些腈酶在较高的pH值和温度下具有增加的活性和稳定性。
• Methods for producing enantiomerically pure alpha-substituted carboxylic acids
  申请人：——

  公开号：US20020012974A1

  公开（公告）日：2002-01-31

  In accordance with the present invention there are provided methods for producing enantiomerically pure &agr;-substituted carboxylic acids, such as, for example, &agr;-amino acids and &agr;-hydroxy acids, said method comprising combining an aldehyde or ketone with a cyanide and ammonia or an ammonium salt or an amine, in the presence of a nitrilase or a polypeptide having nitrilase activity which stereoselectively hydrolyzes the amino nitrile or cyanohydrin intermediate under conditions sufficient to produce the carboxylic acid.

  根据本发明提供了一种制备对映纯的α-取代羧酸的方法，例如α-氨基酸和α-羟基酸。该方法包括在存在腈水解酶或具有腈水解酶活性的多肽的条件下，将醛或酮与氰化物、氨或铵盐或胺结合，以立体选择性水解氨基腈或氰醇中间体，从而产生羧酸。
• Nitrilases, Nucleic Acids Encoding Them and Methods for Making and Using Them
  申请人：DeSantis Grace

  公开号：US20100009426A1

  公开（公告）日：2010-01-14

  The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

  本发明涉及到腈酶以及编码腈酶的核酸。此外，还提供了设计新腈酶的方法和使用该方法的方法。这些腈酶在高pH和高温下具有增强的活性和稳定性。
• Aldolases, nucleic acids encoding them and methods for making and using them
  申请人：Burke Ellen

  公开号：US20080020435A1

  公开（公告）日：2008-01-24

  This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

  本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如，但不限于HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸以及制备和使用这些多核苷酸和多肽的方法。在某些实施例中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如，但不限于HMG和/或KHG醛缩酶活性，包括热稳定和热耐受活性，以及编码这些酶的多核苷酸，并制备和使用这些多核苷酸和多肽。根据本发明的多肽可以在各种制药、农业和工业背景下使用。在某些实施例中，本发明提供了用于生产R-2-羟基2-(吲哚-3-甲基)-4-酮戊二酸（R-MP）和某些单味噌味酸的立体异构体（如R，R和S，R单味噌味酸及其盐）以及某些单味噌味酸衍生物的立体异构体（如R，R和S，R构型及其盐）的多肽和生物合成途径。
• Aldolases, Nucleic Acids Encoding Them and Methods for Making and Using Them
  申请人：Weiner David P.

  公开号：US20100095390A1

  公开（公告）日：2010-04-15

  This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. In some embodiments, the invention is directed to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, including thermostable and thermotolerant activity, and polynucleotides encoding these enzymes, and making and using these polynucleotides and polypeptides. The polypeptides in accordance with the invention can be used in a variety of pharmaceutical, agricultural and industrial contexts. In some embodiments, the invention provides polypeptides and biosynthetic pathways that are useful in the production of R-2-hydroxy 2-(indol-3ylmethyl)-4-keto glutaric acid (R-MP) and certain stereoisomers of monatin, such as R,R and S,R monatin, and salts thereof, as well as certain stereoisomers of monatin derivatives, such as the R,R and S,R configurations, and salts thereof.

  本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如，但不限于，HMG和/或KHG醛缩酶活性，编码这些多肽的多核苷酸以及制备和使用这些多核苷酸和多肽的方法。在某些实施例中，本发明涉及具有醛缩酶活性的多肽，包括丙酮酸活性，例如，但不限于，HMG和/或KHG醛缩酶活性，包括热稳定和耐热活性，以及编码这些酶的多核苷酸，以及制备和使用这些多核苷酸和多肽的方法。根据本发明的多肽可以在各种制药、农业和工业环境中使用。在某些实施例中，本发明提供了用于生产R-2-羟基2-(吲哚-3-甲基)-4-酮戊二酸（R-MP）和某些单甜味物质的立体异构体，例如R，R和S，R单甜味物质及其盐，以及某些单甜味物质衍生物的立体异构体，例如R，R和S，R构型及其盐的多肽和生物合成途径。