2-Methyl-3-pentanone ethylene ketal | 61652-09-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-3-pentanone ethylene ketal
• 英文别名: 2-ethyl-2-isopropyl-[1,3]dioxolane；2-Ethyl-2-isopropyl-1,3-cyclopentan；1,3-Dioxolane, 2-ethyl-2-(1-methylethyl)-；2-ethyl-2-propan-2-yl-1,3-dioxolane
• CAS: 61652-09-3
• 化学式: C₈H₁₆O₂
• 分子量: 144.214
• InChiKey: ZIVZPISSSGMNFL-UHFFFAOYSA-N

物化性质

• 沸点：
  140 °C
• 密度：
  0.941 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Methyl-3-pentanone ethylene ketal 、 1,2,4,5-四氰基苯 以80%的产率得到
  参考文献：
  名称：

  Mella Mariella, Freccero Mauro, Albini Angelo, J. Org. Chem, 59 (1994) N 5, S 1047-1052

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-3-戊酮 、 乙二醇 在 magnesium sulfate 、 (E)-1-(甲基磺酰基)-2-苯偶氮 、 原甲酸三甲酯 作用下， 以> 99 %的产率得到2-Methyl-3-pentanone ethylene ketal
  参考文献：
  名称：

  用于羰基可见光驱动保护的通用无金属协议

  摘要：

  羰基保护：这项工作强调了芳基偶氮砜作为非离子光致产酸剂 (PAG) 在可见光照射下促进醛和酮有效转化为缩醛、缩酮和 1,3-恶唑烷的潜力。这种方法利用了所采用的温和条件，并表现出易于扩展和广泛的底物范围（包括 80 个示例）。

  DOI：

  10.1002/cssc.202201998

文献信息

• DRUG DERIVATIVES
  申请人：Craighead Mark

  公开号：US20130225594A1

  公开（公告）日：2013-08-29

  The present invention relates to derivatives of known active pharmaceutical compounds. These derivatives are differentiated from the parent active compound by virtue of being redox derivatives of the active compound. This means that one or more of the functional groups in the active compound has been converted to another group in one or more reactions which may be considered to represent a change of oxidation state. We refer to these compounds generally as redox derivatives. The derivatives of the invention may be related to the original parent active pharmaceutical compound by only a single step transformation, or may be related via several synthetic steps including one or more changes of oxidation state. In certain cases, the functional group obtained after two or more transformations may be in the same oxidation state as the parent active compound (and we include these compounds in our definition of redox derivatives). In other cases, the oxidation state of the derivative of the invention may be regarded as being different from that of the parent compound. In many cases, the compounds of the invention have inherent therapeutic activity on their own account. In some cases, this activity relative to the same target or targets of the parent compound is as good as or better than the activity which the parent compound has against the target or targets.

  本发明涉及已知活性药物化合物的衍生物。这些衍生物通过是活性化合物的氧化还原衍生物与母体活性化合物相区别。这意味着活性化合物中的一个或多个官能团已转化为另一组，在一项或多项反应中，这可以被认为代表氧化态的变化。我们通常将这些化合物称为氧化还原衍生物。发明中的衍生物可能与原始母体活性药物化合物仅通过单一步骤转换有关，或者可能通过包括一个或多个氧化态变化的几个合成步骤与之相关。在某些情况下，经过两个或更多转换后获得的官能团可能与母体活性化合物处于相同的氧化态（我们将这些化合物包括在我们的氧化还原衍生物定义中）。在其他情况下，发明的衍生物的氧化态可以被认为是与母体化合物不同的。在许多情况下，发明中的化合物本身就具有固有的治疗活性。在某些情况下，相对于母体化合物的相同靶点或靶点，这种活性与母体化合物针对该靶点或靶点的活性一样好或更好。
• STEROL ANALOGS AND USES THEREOF
  申请人：ModernaTX, Inc.

  公开号：US20220402965A1

  公开（公告）日：2022-12-22

  The invention relates to compositions and methods for the preparation, manufacture, and therapeutic use of compositions comprising mRNA and a lipid nanoparticle comprising a compound of the invention and an ionizable lipid.

  本发明涉及包含mRNA和脂质纳米粒子的组合物的制备、制造和治疗用途的方法和组合物，所述脂质纳米粒子包括本发明的化合物和可离子化脂质。
• Photochemical reaction of benzene-1,2,4,5-tetracarbonitrile with the ketals of cyclic and bicyclic ketones
  作者：Mariella Mella、Mauro Freccero、Angelo Albini

  DOI：10.1021/jo00084a021

  日期：1994.3

  The radical cations of the ethylene ketals of some cyclic and bicyclic ketones are generated by single electron transfer to excited benzene-1,2,4,5-tetracarbonitrile (TCB). Their fragmentation yields 1,5- and 1,6-distonic radical cations, which add to TCB-. to give [omega-[(2-hydroxyethoxy)carbonyl] alkyl]benzenetricarbonitriles. The reduction of the radical center occurs only to a small extent, and is enhanced in the presence of dodecylmercaptan, in the case of hindered radicals. The reaction of the camphor ethylene ketal (both alkylation of TCB and reduction) occurs with total diastereoselectivity at the reacting radical center.
• Mella Mariella, Freccero Mauro, Albini Angelo, J. Org. Chem, 59 (1994) N 5, S 1047-1052
  作者：Mella Mariella, Freccero Mauro, Albini Angelo

  DOI：——

  日期：——
• NAYANOV V. P.; ZORIN V. V.; ZLOTSKIJ S. S.; TERENTEV A. B.; RAXMANKULOV D+, ZH. PRIKL. XIMII <ZRKN-BC>, 1976, 49, HO 10, 2350-2352
  作者：NAYANOV V. P.、 ZORIN V. V.、 ZLOTSKIJ S. S.、 TERENTEV A. B.、 RAXMANKULOV D+

  DOI：——

  日期：——