Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor (PPAR) &agr;
申请人:Kyorin Pharmaceutical Co., Ltd.
公开号:US06506797B1
公开(公告)日:2003-01-14
The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor &agr; (PPAR&agr;), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride).
It relates to a substituted phenylpropanoic acid derivatives represented by a general formula (1),
their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.
本发明提供了一种新型取代苯丙酸衍生物,它们通过作为人类过氧化物酶体增殖物激活受体α(PPARα)的配体结合而激活,并表现出强效的降低血液中脂质(胆固醇和甘油三酯)的作用。它涉及一种由通式(1)表示的取代苯丙酸衍生物,它们的药学上可接受的盐和水合物,以及制备它们的方法。