6,6'-Dimethoxy-2,2'-biphenyl-19-C-5 | 155524-10-0

• 分子结构分类: 有机化合物
• 英文名称: 6,6'-Dimethoxy-2,2'-biphenyl-19-C-5
• 英文别名: 3,27-Dimethoxy-9,12,15,18,21-pentaoxatricyclo[21.4.0.02,7]heptacosa-1(23),2(7),3,5,24,26-hexaene
• CAS: 155524-10-0
• 化学式: C₂₄H₃₂O₇
• 分子量: 432.514
• InChiKey: UZJQAPADPNOHAC-UHFFFAOYSA-N

物化性质

• 沸点：
  626.7±55.0 °C(predicted)
• 密度：
  1.081±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6,6'-Dimethoxy-2,2'-biphenyl-19-C-5 在 乙硫醇钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以80%的产率得到6,6'-dihydroxy-2,2'-biphenyl-19-crown-5
  参考文献：
  名称：

  Synthesis of a New Allosteric Carrier Containing Three Conformationally Related Subunits

  摘要：

  A new allosteric carrier was prepared. This compound consists of three crown ether subunits in which conformational information is transferred through two biphenyl systems. This system is able to complex nonionic species in both external crown ether subunits. The allosteric cooperativity in this system was established and its ability to transport Hg(CN)(2) has been studied.

  DOI：

  10.1021/jo00090a010
• 作为产物：
  描述：

  2-氨基-3-甲氧基苯甲酸 在 盐酸 、 ammonium hydroxide 、 sodium hydroxide 、 lithium aluminium tetrahydride 、 硫酸 、 盐酸羟胺 、 sodium hydride 、 copper(II) sulfate 、 sodium nitrite 作用下， 以 四氢呋喃 为溶剂， 反应 60.0h， 生成 6,6'-Dimethoxy-2,2'-biphenyl-19-C-5
  参考文献：
  名称：

  Synthesis of a New Allosteric Carrier Containing Three Conformationally Related Subunits

  摘要：

  A new allosteric carrier was prepared. This compound consists of three crown ether subunits in which conformational information is transferred through two biphenyl systems. This system is able to complex nonionic species in both external crown ether subunits. The allosteric cooperativity in this system was established and its ability to transport Hg(CN)(2) has been studied.

  DOI：

  10.1021/jo00090a010

文献信息

• Association constants of alkaline complexes of macrolactones and crown ethers derived from biphenyl. Influence of the position and characteristics of biphenyl substituents
  作者：Ana M. Costero、Miguel Pitarch

  DOI：10.1016/s0040-4020(01)80695-5

  日期：1994.5

  The influence that substituents in the biphenyl moiety have on the association constants of several macrolactones and crown ether derived from biphenyl have been studied. The steric hindrance produced by the presence of substituents in 6,6′ makes some crown ethers less suitable to complex alkaline cations. Carbonyl groups present in macrolactones reduce the effective space inside the hole and smaller

  研究了联苯部分中的取代基对几种大分子内酯和联苯衍生的冠醚的缔合常数的影响。由6,6'中取代基的存在产生的空间位阻使得某些冠醚不太适合于复杂的碱性阳离子。大内酯中存在的羰基会减少孔内的有效空间，并且更适合较小的阳离子。
• Macrolactones and crown ethers derived from biphenyl. Electronic and steric influence of substituents on its complexation ability
  作者：Ana M. Costero、C. Andreu、M. Pitarch、R. Andreu

  DOI：10.1016/0040-4020(96)00044-0

  日期：1996.3

  Electronic effects as well as steric hindrance must be considered in order to compare the ability of macrolactones and crown ethers for complexing alkali cations and Hg(SCN)2.

  为了比较大内酯和冠醚络合碱金属阳离子和Hg（SCN）2的能力，必须考虑电子效应以及位阻。
• Costero Ana M., Pitarch Miguel, J. Org. Chem, 59 (1994) N 11, S 2939- 2944
  作者：Costero Ana M., Pitarch Miguel

  DOI：——

  日期：——