tert-pentoxy-bis(dimethylamino)methane | 147196-94-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tert-pentoxy-bis(dimethylamino)methane
• 英文别名: N,N,N',N'-tetramethyl-1-(2-methylbutan-2-yloxy)methanediamine
• CAS: 147196-94-9
• 化学式: C₁₀H₂₄N₂O
• 分子量: 188.313
• InChiKey: YHPCWOZOEYQJBS-UHFFFAOYSA-N

物化性质

• 沸点：
  198.4±20.0 °C(Predicted)
• 密度：
  0.876±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (S)-2-biphenyl-4-ylmethyl-5-oxopyrrolidine-1-carboxylic acid t-butyl ester 、 三(二甲氨基)甲烷 、 tert-pentoxy-bis(dimethylamino)methane 、 N,N-dimethylformamide di-tert-pentoxyacetal 反应 2.0h， 生成 (R)-5-biphenyl-4-ylmethyl-3-[1-dimethylaminometh-(E/Z)-ylidene]-2-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  [EN] PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 5-BIPHENYL-4-YL-2-METHYLPENTAN0IC ACID DERIVATIVES
  [FR] NOUVEAUX PROCÉDÉS

  摘要：

  公开号：

  WO2009090251A3
• 作为产物：
  描述：

  (二甲氨基亚甲基)二甲基氯化铵 、 sodium tert-pentoxide 以 四氢呋喃 、 甲苯 为溶剂， 反应 48.0h， 生成 三(二甲氨基)甲烷 、 tert-pentoxy-bis(dimethylamino)methane 、 N,N-dimethylformamide di-tert-pentoxyacetal
  参考文献：
  名称：

  [EN] PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 5-BIPHENYL-4-YL-2-METHYLPENTAN0IC ACID DERIVATIVES
  [FR] NOUVEAUX PROCÉDÉS

  摘要：

  公开号：

  WO2009090251A3

文献信息

• [EN] PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 1-(2H)-ISOQUINOLINONES 6-SUBSTITUÉES
  申请人：SANOFI AVENTIS

  公开号：WO2009080335A1

  公开（公告）日：2009-07-02

  The present invention relates to a process for making 6-substituted-1-(2H)- isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in the process according to the invention and to processes for preparing such intermediates.

  本发明涉及一种制备式（I）的6-取代-1-(2H)-异喹啉酮衍生物的方法，其中R1和n如规范中所述。本发明还涉及用于本发明方法的新型中间体，以及制备这种中间体的方法。
• NEW PROCESSES
  申请人：Hook David

  公开号：US20110046397A1

  公开（公告）日：2011-02-24

  The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

  本发明涉及一种生产NEP抑制剂或其前药的新工艺，特别是包括γ-氨基-δ-联苯基-α-甲基脂肪酸或酸酯骨架的NEP抑制剂。详细来说，根据本发明，新工艺最终与合成制备上述NEP抑制剂的中间体相关，即按照公式（1）或其盐制备的化合物，其中R1和R2独立地是氢或氮保护基，R3是羧基或酯基，优选是羧基或烷基酯。
• Processes
  申请人：Hook David

  公开号：US20140243546A1

  公开（公告）日：2014-08-28

  The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.

  本发明涉及一种生产NEP抑制剂或其前药的新工艺，特别是包括γ-氨基-δ-联苯基-α-甲基脂肪酸或酸酯骨架的NEP抑制剂。具体而言，根据本发明，新工艺最终与合成中间体有关，以制备上述NEP抑制剂，即化合物公式（1）或其盐，其中R1和R2独立地为氢或氮保护基，R3为羧基或酯基，优选为羧基或烷基酯。
• PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-1-(2H)-ISOQUINOLINONES
  申请人：ROSSEN Kai

  公开号：US20110021779A1

  公开（公告）日：2011-01-27

  The present invention relates to a process for making 6-substituted-1-(2H)-isoquinolinone derivatives of formula (I) wherein R1 and n are as described in the specification. The present invention further relates to novel intermediates which are used in the process according to the invention and to processes for preparing such intermediates.

  本发明涉及一种制备式（I）中R1和n如规范所述的6-取代-1-(2H)-异喹啉酮衍生物的方法。本发明还涉及用于该发明方法的新型中间体以及制备这种中间体的方法。
• PROCESS AND INTERMEDIATES FOR THE PREPARATION OF 5-BIPHENYL-4-YL-2-METHYLPENTANOIC ACID DERIVATIVES
  申请人：Novartis AG

  公开号：EP2245009A2

  公开（公告）日：2010-11-03