(E,2R)-2-methyl-2-(phenylmethoxymethyl)oct-3-en-1-ol | 303142-81-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E,2R)-2-methyl-2-(phenylmethoxymethyl)oct-3-en-1-ol
• CAS: 303142-81-6
• 化学式: C₁₇H₂₆O₂
• 分子量: 262.392
• InChiKey: ZMDXEJFHWRJXET-XLNAKTSKSA-N

物化性质

• 沸点：
  386.1±30.0 °C(Predicted)
• 密度：
  0.977±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E,2R)-2-methyl-2-(phenylmethoxymethyl)oct-3-en-1-ol 在 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 (E,2S)-2-methyl-2-(phenylmethoxymethyl)oct-3-enal
  参考文献：
  名称：

  Novel stereoselective construction of a quaternary carbon: application to synthesis of the cyclopentenedione moiety of madindolines

  摘要：

  Enantioselective synthesis of the cyclopentenedione moiety of madindolines was achieved. Stereoselective construction of a quaternary carbon was realized by alkylation of an enolate possessing chiral auxiliary. Cyclopentenedione was derived from a triketone precursor by intramolecular condensation. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00937-0
• 作为产物：
  描述：

  (E)-2-methyloct-2-enoic acid 在 lithium aluminium tetrahydride 、 正丁基锂 、 氯化亚砜 、 sodium hexamethyldisilazane 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 4.17h， 生成 (E,2R)-2-methyl-2-(phenylmethoxymethyl)oct-3-en-1-ol
  参考文献：
  名称：

  Novel stereoselective construction of a quaternary carbon: application to synthesis of the cyclopentenedione moiety of madindolines

  摘要：

  Enantioselective synthesis of the cyclopentenedione moiety of madindolines was achieved. Stereoselective construction of a quaternary carbon was realized by alkylation of an enolate possessing chiral auxiliary. Cyclopentenedione was derived from a triketone precursor by intramolecular condensation. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)00937-0

文献信息

• Novel stereoselective construction of a quaternary carbon: application to synthesis of the cyclopentenedione moiety of madindolines
  作者：Seijiro Hosokawa、Kazuhiko Sekiguchi、Manabu Enemoto、Susumu Kobayashi

  DOI：10.1016/s0040-4039(00)00937-0

  日期：2000.8

  Enantioselective synthesis of the cyclopentenedione moiety of madindolines was achieved. Stereoselective construction of a quaternary carbon was realized by alkylation of an enolate possessing chiral auxiliary. Cyclopentenedione was derived from a triketone precursor by intramolecular condensation. (C) 2000 Elsevier Science Ltd. All rights reserved.