Methyl 3-methyl-1,2,3a,4,5,7-hexahydropyrrolo[2,3-d]carbazole-6-carboxylate | 91176-85-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Methyl 3-methyl-1,2,3a,4,5,7-hexahydropyrrolo[2,3-d]carbazole-6-carboxylate
• CAS: 91176-85-1
• 化学式: C₁₇H₂₀N₂O₂
• 分子量: 284.358
• InChiKey: DCSRKMKTHAOMBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Methyl 3-methyl-1,2,3a,4,5,7-hexahydropyrrolo[2,3-d]carbazole-6-carboxylate 在 盐酸 作用下， 以 乙醚 为溶剂， 生成 3-Methyl-2,3,3a,4,5,7-hexahydro-1H-pyrrolo[2,3-d]carbazole-6-carboxylic acid methyl ester; hydrochloride
  参考文献：
  名称：

  Studies in biomimetic alkaloid syntheses. 6. Alternative pathways to secodines and their acyclic enamino acrylate analogs. Total syntheses of desethylibophyllidine, D-norvincadifformine, desethylvincadifformine, 20-methyldesethylvincadifformine, and 3-oxovincadifformine

  摘要：

  DOI：

  10.1021/jo00323a007
• 作为产物：
  描述：

  methyl 3-benzyl-1,2,3,3a,4,5-hexahydro-7H-pyrrolo(2,3-d)carbazole-6-carboxylate 在 palladium on activated charcoal 氢气 作用下， 以 二氯甲烷 、 溶剂黄146 为溶剂， 反应 48.0h， 生成 Methyl 3-methyl-1,2,3a,4,5,7-hexahydropyrrolo[2,3-d]carbazole-6-carboxylate
  参考文献：
  名称：

  Studies in biomimetic alkaloid syntheses. 6. Alternative pathways to secodines and their acyclic enamino acrylate analogs. Total syntheses of desethylibophyllidine, D-norvincadifformine, desethylvincadifformine, 20-methyldesethylvincadifformine, and 3-oxovincadifformine

  摘要：

  DOI：

  10.1021/jo00323a007

文献信息

• Pyrrolo(2,3-d)carbazole derivatives, preparation thereof and their therapeutical use
  申请人：OMNICHEM Société anonyme

  公开号：EP0064317A2

  公开（公告）日：1982-11-10

  This invention relates to novel alkyl pyrrolo (2,3-d) carbazole-6-carboxylates and to addition salts thereof; and to preparation of the same by a synthesis sequence starting from a tryptamine and a 3-halopyruvate and involving a rearrangement of an addition compound with an aldehyde, said rearrangement being effected by Nb-alkylation of the aforementioned addition compound; and to pharmaceutical compositions containing the same; and to novel tetrahy- droazepinoindoles used in the preparation of the same.

  本发明涉及新型烷基吡咯并(2,3-d)咔唑-6-羧酸盐及其加成盐；涉及以色胺和 3-卤代丙酮酸为起始原料，通过加成化合物与醛的重排（所述重排是通过上述加成化合物的 Nb-烷基化实现的）的合成顺序制备上述物质；涉及含有上述物质的药物组合物；还涉及用于制备上述物质的新型四- droazepinoindoles。
• Methyleneindolines, indolenines, and indoleniniums. 19. A new entry into the hexahydropyrrolidino[2,3-d]carbazole system
  作者：Joseph Vercauteren、Georges Massiot、Jean Levy

  DOI：10.1021/jo00191a042

  日期：1984.8