Tert-butyl N-[1-(2-hydroxyethyl)cyclobutyl]carbamate | 1028266-97-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Tert-butyl N-[1-(2-hydroxyethyl)cyclobutyl]carbamate
• CAS: 1028266-97-8
• 化学式: C₁₁H₂₁NO₃
• 分子量: 215.293
• InChiKey: QTCZTBMOUJLXQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl N-[1-(2-hydroxyethyl)cyclobutyl]carbamate 在 草酰氯 、 potassium tert-butylate 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 ethyl (E)-4-[1-[(2-methylpropan-2-yl)oxycarbonylamino]cyclobutyl]but-2-enoate
  参考文献：
  名称：

  Synthesis and in vitro characterization of new growth hormone secretagogues derived from ipamorelin with dipeptidomimetic N-terminals

  摘要：

  The structural requirements for N-terminal features for the minimal structure of growth hormone secretagogues derived from ipamorelin are investigated. It is found, that incorporation of nonpolar peptidomimetic amino acids at the N-terminal can replace the Aib-His moiety and lead to compounds with high in vitro potency with respect to their growth hormone secretagogue properties. New unnatural amino acids with double bonds, ether-linkages, and 1,3-phenylene-moieties in the backbone proved to be valuable dipeptidomimetics. Using them, growth hormone secretagogues with high potencies were obtained. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80086-5
• 作为产物：
  描述：

  亚甲基环丁烷 在 4-二甲氨基吡啶 、 lithium hydroxide 、 锂硼氢 、 三乙胺 、 sodium sulfite 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 34.0h， 生成 Tert-butyl N-[1-(2-hydroxyethyl)cyclobutyl]carbamate
  参考文献：
  名称：

  Synthesis and in vitro characterization of new growth hormone secretagogues derived from ipamorelin with dipeptidomimetic N-terminals

  摘要：

  The structural requirements for N-terminal features for the minimal structure of growth hormone secretagogues derived from ipamorelin are investigated. It is found, that incorporation of nonpolar peptidomimetic amino acids at the N-terminal can replace the Aib-His moiety and lead to compounds with high in vitro potency with respect to their growth hormone secretagogue properties. New unnatural amino acids with double bonds, ether-linkages, and 1,3-phenylene-moieties in the backbone proved to be valuable dipeptidomimetics. Using them, growth hormone secretagogues with high potencies were obtained. (C) Elsevier, Paris.

  DOI：

  10.1016/s0223-5234(99)80086-5

文献信息

• US7514430B2
  申请人：——

  公开号：US7514430B2

  公开（公告）日：2009-04-07
• [EN] CHROMANE AMIDINE MONOBACTAM COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS<br/>[FR] COMPOSÉS MONOBACTAME AMIDINE CHROMANE POUR LE TRAITEMENT D'INFECTIONS BACTÉRIENNES
  申请人：[en]MERCK SHARP & DOHME LLC

  公开号：WO2024019916A2

  公开（公告）日：2024-01-25

  The present invention relates to monobactam compounds of Formula (I):(Formula (I)) and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of structural formula I or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of structural formula I, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.
• TARGETED DEGRADATION OF VAV1
  申请人：[en]MONTE ROSA THERAPEUTICS, INC.

  公开号：WO2024151547A1

  公开（公告）日：2024-07-18

  This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt thereof) that degrades Proto-oncogene VAV 1 protein (VAV1). The chemical entities are useful, e.g., for treating a subject (e.g., a human subject) having an inflammatory or autoimmune disorder.
• US2023/159517
  申请人：——

  公开号：——

  公开（公告）日：——
• Synthesis and in vitro characterization of new growth hormone secretagogues derived from ipamorelin with dipeptidomimetic N-terminals
  作者：Bernd Peschke、Michael Ankersen、Birgit Sehested Hansen、Thomas Kruse Hansen、Nils Langeland Johansen、Jesper Lau、Kjeld Madsen、Hans Petersen、Henning Thøgersen、Brett Watson

  DOI：10.1016/s0223-5234(99)80086-5

  日期：1999.5

  The structural requirements for N-terminal features for the minimal structure of growth hormone secretagogues derived from ipamorelin are investigated. It is found, that incorporation of nonpolar peptidomimetic amino acids at the N-terminal can replace the Aib-His moiety and lead to compounds with high in vitro potency with respect to their growth hormone secretagogue properties. New unnatural amino acids with double bonds, ether-linkages, and 1,3-phenylene-moieties in the backbone proved to be valuable dipeptidomimetics. Using them, growth hormone secretagogues with high potencies were obtained. (C) Elsevier, Paris.