4-(3-Hydroxypropyl)-4-<3-(benzyloxy)propyl>-1,7-bis(benzyloxy)heptane | 135646-74-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(3-Hydroxypropyl)-4-<3-(benzyloxy)propyl>-1,7-bis(benzyloxy)heptane
• 英文别名: 4-(3-hydroxypropyl)-4-(3-benzyloxypropyl)-1,7-bis(benzyloxy)heptane；7-benzyloxy-4,4-bis-(3-benzyloxy-propyl)-heptan-1-ol；7-Phenylmethoxy-4,4-bis(3-phenylmethoxypropyl)heptan-1-ol
• CAS: 135646-74-1
• 化学式: C₃₄H₄₆O₄
• 分子量: 518.737
• InChiKey: UHFHRAGDGMMYGG-UHFFFAOYSA-N

物化性质

• 沸点：
  633.3±55.0 °C(Predicted)
• 密度：
  1.055±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  38
• 可旋转键数：
  21
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(3-Hydroxypropyl)-4-<3-(benzyloxy)propyl>-1,7-bis(benzyloxy)heptane 在 硫酸 、 氢溴酸 作用下， 反应 12.0h， 以72%的产率得到Tetrakis(3-bromopropyl)methane
  参考文献：
  名称：

  Micelles series. 31. Building blocks for cascade polymers. 11. Synthesis of functionalized cascade cores: tetrakis(.omega.-bromoalkyl)methanes

  摘要：

  A series of tetrakis(bromoalkyl)methanes was synthesized and characterized. The tetrakis(3-bromopropyl)methane was chosen as ideal core to cascade polymers, since it undergoes facile substitution with bulky nucleophiles, denoting the need for at least three carbon atoms between the quaternary center and the leaving group to circumvent major steric problems caused by the core carbon. The readily available 4-nitro-4-(3-hydroxypropyl)-1,7-heptanediol was used to afford a novel entry to tetrakis(3-bromopropyl)methane as well as other building blocks to cascade polymers.

  DOI：

  10.1021/jo00056a023
• 作为产物：
  描述：

  4-(3-羟基丙基)-4-硝基-1,7-庚二醇 在 氢氧化钾 、 硼烷四氢呋喃络合物 、 2,2'-azobis(4-methylpropionitrile) 、 双氧水 、 三正丁基氢锡 作用下， 以 四氢呋喃 、 乙醇 、 水 、 二甲基亚砜 、 甲苯 为溶剂， 反应 28.0h， 生成 4-(3-Hydroxypropyl)-4-<3-(benzyloxy)propyl>-1,7-bis(benzyloxy)heptane
  参考文献：
  名称：

  Micelles series. 31. Building blocks for cascade polymers. 11. Synthesis of functionalized cascade cores: tetrakis(.omega.-bromoalkyl)methanes

  摘要：

  A series of tetrakis(bromoalkyl)methanes was synthesized and characterized. The tetrakis(3-bromopropyl)methane was chosen as ideal core to cascade polymers, since it undergoes facile substitution with bulky nucleophiles, denoting the need for at least three carbon atoms between the quaternary center and the leaving group to circumvent major steric problems caused by the core carbon. The readily available 4-nitro-4-(3-hydroxypropyl)-1,7-heptanediol was used to afford a novel entry to tetrakis(3-bromopropyl)methane as well as other building blocks to cascade polymers.

  DOI：

  10.1021/jo00056a023

文献信息

• Metallomicellanols: incorporation of ruthenium(<scp>II</scp>)–2,2′: 6′,2″-terpyridine triads into cascade polymers
  作者：George R. Newkome、Francesca Cardullo、Edwin C. Constable、Charles N. Moorefield、Alexander M. W. Cargill Thompson

  DOI：10.1039/c39930000925

  日期：——

  Facile alkoxylation of 4′-chloro-2,2′ :6′,2″-terpyridine with the mono- and tri-hydroxylic cascade (dendritic) building blocks, 4-(3-hydroxypropyl)-4-(3-benzyloxypropyl)-1,7-bis(benzyloxy)heptane 4 and 4-amino-4-(3-hydroxypropyl)heptane-1,7-diol 3, has allowed the synthesis of a dodecaruthenium macromolecule 11 employing ligand–metal–ligand connectivity.

  4′-氯-2,2′:6′,2″-三吡啶的易于醇氧基化反应与单羟基和三羟基级联（树状）建筑块4-(3-羟丙基)-4-(3-苄氧丙基)-1,7-双（苄氧基）庚烷和4-amino-4-(3-羟丙基)庚烷-1,7-二醇的结合，使得能够合成一个十二钌的大分子11，采用配体-金属-配体的连接方式。
• Solid Substrate Comprising Array of Dendrons and Methods for Using the Same
  申请人：Park Joon Won

  公开号：US20100093553A1

  公开（公告）日：2010-04-15

  The present invention provides solid supports comprising a surface bound array of dendrons and methods for using the same.

  本发明提供了固体支撑体，其包括表面结合的树枝状分子阵列，以及使用它们的方法。
• BIOMOLECULE INTERACTION USING ATOMIC FORCE MICROSCOPE
  申请人：Park Joon-Won

  公开号：US20080113353A1

  公开（公告）日：2008-05-15

  The present patent application describes a cantilever for atomic force microscopy (AFM), which includes a cantilever body having a fixed end and a free end, the free end having a surface region being chemically modified by a dendron in which a plurality of termini of the branched region of the dendron are bound to the surface, and a terminus of the linear region of the dendron is functionalized.
• US8673621B2
  申请人：——

  公开号：US8673621B2

  公开（公告）日：2014-03-18
• US9175335B2
  申请人：——

  公开号：US9175335B2

  公开（公告）日：2015-11-03